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Volume 37 Issue 1
Jan.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(1): 200-203

Clinical application of regional citrate anticoagulation in continuous renal replacement therapy for patients with liver failure

DOI: 10.3969/j.issn.1001-5256.2021.01.044

  • Department of Emergency, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

  • Received Date: 2020-07-16
  • Accepted Date: 2020-08-13
  • Published Date: 2021-01-20
    Abstract
  • In vitro anticoagulation is a key technique in continuous renal replacement therapy (CRRT), and heparin was once the preferred anticoagulant for CRRT, but its clinical application is limited due to the high risk of bleeding. Citrate, as a new regional anticoagulant, has received more and more attention and recommendation in recent years, but there are still controversies over its application in patients with liver failure. With reference to relevant literature in China and globally, this article reviews the metabolic characteristics and monitoring methods of regional citrate anticoagulation and its safety in CRRT for patients with liver failure.

     

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