Research advances in animal models of acute liver failure

Fuli LONG; Yong LIN; Ziming PENG; Feng FENG; Jianling ZHANG; Dewen MAO; Ailing WEI

doi:10.3969/j.issn.1001-5256.2021.01.045

Volume 37 Issue 1

Jan. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(1): 204-208

PDF( 2266 KB)

Research advances in animal models of acute liver failure

DOI: 10.3969/j.issn.1001-5256.2021.01.045

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530200, China
2.
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
3.
College of Adult Education, Guangxi University of Chinese Medicine, Nanning 530001, China

Received Date: 2020-06-20
Accepted Date: 2020-08-08
Published Date: 2021-01-20

Abstract

Abstract

Acute liver failure is a serious and complex liver disease with a high short-term mortality rate. Its pathogenesis remains unknown and there is still a lack of effective drugs. Animal models play an important role in further revealing the pathogenesis of acute liver failure and the therapeutic mechanism of drugs, and the selection of experimental animals and preparation methods is the key to the effective implementation of research. This article summarizes the commonly used and new animal models of acute liver failure in recent years and the corresponding preparation methods and divides the animal models of acute liver failure into following four categories: chemical drug model, surgical model, infection model, and other models. Meanwhile, the above models are evaluated based on Terblanche and Hickman evaluation criteria for liver failure models, hoping to provide a reference for model selection and evaluation in basic research on this disease.
- Liver Failure, Acute,
- Disease Models, Animal,
- Modeling Method

FullText(HTML)

References(48)

References

[1]	FATHI-KAZEROONI M, TAVOOSIDANA G, TAGHIZADEH-JAHED M, et al. Comparative restoration of acute liver failure by menstrual blood stem cells compared with bone marrow stem cells in mice model[J]. Cytotherapy, 2017, 19(12): 1474-1490. DOI: 10.1016/j.jcyt.2017.08.022
[2]	ZHOU P, XIA J, GUO G, et al. A Macaca mulatta model of fulminant hepatic failure[J]. World J Gastroenterol, 2012, 18(5): 435-444. DOI: 10.3748/wjg.v18.i5.435
[3]	MEJIDO D, de OLIVEIRA JM, GASPAR A, et al. Evidences of HEV genotype 3 persistence and reactivity in liver parenchyma from experimentally infected cynomolgus monkeys (Macaca fascicularis)[J]. PLoS One, 2019, 14(6): e0218472. DOI: 10.1371/journal.pone.0218472
[4]	RAMACHANDRAN A, JAESCHKE H. A mitochondrial journey through acetaminophen hepatotoxicity[J]. Food Chem Toxicol, 2020, 140: 111282. DOI: 10.1016/j.fct.2020.111282
[5]	MING YN, LI CM, ZHANG JY, et al. Mitochondrial genome transcriptional changes in models of acetaminophen-induced acute liver injury and liver failure[J]. Chin Hepatol, 2016, 21(6): 447-451. (in Chinese) DOI: 10.3969/j.issn.1008-1704.2016.06.007 明雅南, 李春敏, 张静怡, 等. 对乙酰氨基酚诱导的急性肝损伤和肝衰竭模型中线粒体基因组转录改变[J]. 肝脏, 2016, 21(6): 447-451. DOI: 10.3969/j.issn.1008-1704.2016.06.007
[6]	ORTEGA L, LANDA GARCIA JI, TORRES GARCIA A, et al. Acetaminophen-induced fulminant hepatic failure in dogs[J]. Hepatology, 1985, 5(4): 673-676. DOI: 10.1002/hep.1840050425
[7]	DARGUE R, ZIA R, LAU C, et al. Metabolism and effects on endogenous metabolism of paracetamol (acetaminophen) in a porcine model of liver failure[J]. Toxicol Sci, 2020, 175(1): 87-97. DOI: 10.1093/toxsci/kfaa023
[8]	CHASTRE A, BÉLANGER M, BEAUCHESNE E, et al. Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications[J]. PLoS One, 2012, 7(11): e49670. DOI: 10.1371/journal.pone.0049670
[9]	WU XH, GUO Y, LIU CF, et al. Establishment of acute liver injury model induced by LPS/D-GalN in mice[J]. Acta Lab Anim Sci Sin, 2014, 22(3): 15-19. (in Chinese) DOI: 10.3969/j.issn.1005-4847.2014.03.003 吴小红, 郭彦, 刘晨风, 等. LPS/D-GalN诱导小鼠急性肝损伤模型的建立[J]. 中国实验动物学报, 2014, 22(3): 15-19. DOI: 10.3969/j.issn.1005-4847.2014.03.003
[10]	LONG FL, CHEN XM, XIE L, et al. Effects of Jiedu Huayu Granule on cytokines and hepatic tissue in rats with acute liver failure[J]. Chin J Exp Med Formul, 2016, 22(20): 101-105. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201620022.htm 龙富立, 陈小明, 谢丽, 等. 解毒化瘀颗粒对急性肝衰竭大鼠细胞因子及肝组织的影响[J]. 中国实验方剂学杂志, 2016, 22(20): 101-105. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201620022.htm
[11]	KITAZAWA T, TSUJIMOTO T, KAWARATANI H, et al. Salvage effect of E5564, Toll-like receptor 4 antagonist on D-galactosamine and lipopolysaccharide-induced acute liver failure in rats[J]. J Gastroenterol Hepatol, 2010, 25(5): 1009-1012. DOI: 10.1111/j.1440-1746.2009.06145.x
[12]	PENG CH, XIAO WD, WU WD, et al. A pig model of acute liver failure was established by intravenous injection of D-galactosamine and lipopolysaccharide[J]. Natl Med J China, 2005, 85(21): 1464-1467. (in Chinese) DOI: 10.3760/j:issn:0376-2491.2005.21.009 彭承宏, 肖卫东, 吴伟顶, 等. 门静脉注射D-氨基半乳糖和脂多糖建立猪急性肝功能衰竭模型[J]. 中华医学杂志, 2005, 85(21): 1464-1467. DOI: 10.3760/j:issn:0376-2491.2005.21.009
[13]	ZHANG L, KANG W, LEI Y, et al. Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with D-galactosamine-induced acute liver failure[J]. Toxicol Lett, 2011, 204(1): 92-99. DOI: 10.1016/j.toxlet.2011.04.016
[14]	ZHANG F, HE Y, DUAN Z. Changes of high mobility group box 1 in serum of pig acute hepatic failure model and significance[J]. J Huazhong Univ Sci Technolog Med Sci, 2008, 28(1): 52-55. DOI: 10.1007/s11596-008-0113-x
[15]	PATZER JF 2nd, BLOCK GD, KHANNA A, et al. D-galactosamine based canine acute liver failure model[J]. Hepatobiliary Pancreat Dis Int, 2002, 1(3): 354-367. http://qikan.cqvip.com/Qikan/Article/Detail?id=1003034289
[16]	FENG L, CAI L, HE GL, et al. Novel D-galactosamine-induced cynomolgus monkey model of acute liver failure[J]. World J Gastroenterol, 2017, 23(42): 7572-7583. DOI: 10.3748/wjg.v23.i42.7572
[17]	PARK JH, KUM YS, LEE TI, et al. Melittin attenuates liver injury in thioacetamide-treated mice through modulating inflammation and fibrogenesis[J]. Exp Biol Med (Maywood), 2011, 236(11): 1306-1313. DOI: 10.1258/ebm.2011.011127
[18]	YANG TY. Effect of Jianpi Huashi jiedu prescription on TAA-induced acute liver failure in mice[D]. Beijing: Beijing University of Chinese Medicine, 2013. (in Chinese) 杨天翼. 健脾化湿解毒方对TAA诱导的急性肝衰竭小鼠模型的影响[D]. 北京: 北京中医药大学, 2013.
[19]	MAO DW, QIU H, LIU J, et al. Effect of Jiedu Huayu Recipe Ⅱ on TNF-α/TNFR1 and Fas/FasL expression in rats with fulminant liver failure[J]. J Chin Med Pharm, 2007, 35(1): 13-16, 64. (in Chinese) DOI: 10.3969/j.issn.1002-2392.2007.01.005 毛德文, 邱华, 刘洁, 等. 解毒化瘀Ⅱ方对暴发性肝衰竭大鼠TNF-α/TNFR1及Fas/FasL表达的影响[J]. 中医药学报, 2007, 35(1): 13-16, 64. DOI: 10.3969/j.issn.1002-2392.2007.01.005
[20]	ZHANG MH, JIA L, DU H, et al. Dose-effect relationship of thioacetamide induced hepatic encephalopathy in rats[J]. Acad J Guangzhou Med Coll, 2004, 32(3): 72-74. (in Chinese) DOI: 10.3969/j.issn.1008-1836.2004.03.022 张美华, 贾林, 杜洪, 等. 硫代乙酰胺致大鼠肝性脑病模型的量-效关系[J]. 广州医学院学报, 2004, 32(3): 72-74. DOI: 10.3969/j.issn.1008-1836.2004.03.022
[21]	RAMA RAO KV, VERKMAN AS, CURTIS KM, et al. Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure[J]. Neurobiol Dis, 2014, 63: 222-228. DOI: 10.1016/j.nbd.2013.11.018
[22]	WANG H, WU EQ. Effect of the Mongolian medicine Jiawang-9 on carbon tetrachloride induced acute liver failure in rats[J]. Chin J Exp Med Formul, 2013, 8: 238-241. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201308067.htm 王欢, 乌恩其. 蒙药祛"热"凉性方剂给旺-9对四氯化碳诱导大鼠急性肝衰竭的影响[J]. 中国实验方剂学杂志, 2013, 8: 238-241. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201308067.htm
[23]	NARDO B, TSIVIAN M, NERI F, et al. Extracorporeal portal vein oxygenation improves outcome of acute liver failure in swin[J]. Transplant Proc, 2008, 40: 2046-2048. DOI: 10.1016/j.transproceed.2008.05.026
[24]	HUANG JW. Carbon tetrachloride to construct acute liver failure model in dogs and explore the effect of blood purification[D]. Guangzhou: Jinan University, 2010. (in Chinese) 黄建伟. 四氯化碳构建犬急性肝衰竭模型及血液净化效果探索[D]. 广州: 暨南大学, 2010.
[25]	ZHANG HY, LOU JL, LI L. Establishment of a model of chronic plus acute liver failure induced by carbon tetrachloride combined with D-GalN lipopolysaccharide[J]. Beijing Med J, 2011, 33(3): 199-202. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-BJYX201103002.htm 张慧芸, 娄金丽, 李宁. 四氯化碳联合D-氨基半乳糖、脂多糖诱导慢加急性肝衰竭模型的建立[J]. 北京医学, 2011, 33(3): 199-202. https://www.cnki.com.cn/Article/CJFDTOTAL-BJYX201103002.htm
[26]	HEYMANN F, HAMESCH K, WEISKIRCHEN R, et al. The concanavalin A model of acute hepatitis in mice[J]. Lab Anim, 2015, 49: 12-20. DOI: 10.1177/0023677215572841
[27]	GAO YD, TIAN Y, ZHANG XY, et al. Effect of magnesium isoglycyrrhizinate on concanavalin A-induced acute liver failure in mice[J]. J Clin Hepatol, 2020, 36(7): 1571-1576. (in Chinese) DOI: 10.3969/j.issn.1001-5256.2020.07.024 高钰迪, 田原, 张向颖, 等. 异甘草酸镁对刀豆蛋白A诱导的急性肝衰竭小鼠模型的影响[J]. 临床肝胆病杂志, 2020, 36(7): 1571-1576. DOI: 10.3969/j.issn.1001-5256.2020.07.024
[28]	LI S, BI Y, WANG Q, et al. Transplanted mouse liver stem cells at different stages of differentiation ameliorate concanavalin A-induced acute liver injury by modulating Tregs and Th17 cells in mice[J]. Am J Transl Res, 2019, 11(12): 7324-7337. http://www.ncbi.nlm.nih.gov/pubmed/31934281
[29]	ZHU LL, LI R, ZHANG JP, et al. The protective effect of Buzhong Yiqi Decoction on acute liver failure induced by candied bean protein A in mice[J]. Chin J Exp Med Formul, 2020, 1(1): 10-16. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202001003.htm 朱鏐娈, 李蕊, 张剑平, 等. 补中益气汤对刀豆蛋白A致小鼠急性肝衰竭的保护作用[J]. 中国实验方剂学杂志, 2020, 1(1): 10-16. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202001003.htm
[30]	IWAKI T, SUGIMURA M, NISHIHIRA J, et al. Recombinant adenovirus vector bearing antisense macrophage migration inhibitory factor cDNA prevents acute lipopolysaccharide-induced liver failure in mice[J]. Lab Invest, 2003, 83(4): 561-570. DOI: 10.1097/01.LAB.0000062857.26210.EF
[31]	YANG YF, TAN DM, XIE YT, et al. Mycophenolate mofetil prevents lethal acute liver failure in mice induced by bacille Calmette-Guérin and lipopolysaccharide[J]. J Gastroenterol Hepatol, 2008, 23(4): 611-618. DOI: 10.1111/j.1440-1746.2007.05169.x
[32]	ISHIGURO S, TAKADA Y, GU M, et al. Auxiliary partial orthotopic liver transplantation for fulminant hepatitis: Regeneration of the diseased native liver in a pig model[J]. Transplantation, 2003, 75(11): 1901-1904. DOI: 10.1097/01.TP.0000065293.75456.08
[33]	FILIPPONI F, BOGGI U, MEACCI L, et al. A new technique for total hepatectomy in the pig for testing liver support devices[J]. Surgery, 1999, 125(4): 448-455. DOI: 10.1016/S0039-6060(99)70013-9
[34]	KNUBBEN K, THIEL C, SCHENK M, et al. A new surgical model for hepatectomy in pigs[J]. Eur Surg Res, 2008, 40(1): 41-46. DOI: 10.1159/000108765
[35]	SKAWRAN S, PALMES D, BUDNY T, et al. Development and evaluation of an experimental model for investigating the pathogenesis and therapeutic strategies of acute liver failure[J]. Transplant Proc, 2003, 35(8): 3142-3146. DOI: 10.1016/j.transproceed.2003.10.022
[36]	HUNG KC, YONG CC, CHEN YS, et al. A surgical model of fulminant hepatic failure in rabbits[J]. Liver Int, 2007, 27(10): 1333-1341.
[37]	CHEN XP, XUE YL, LI XJ, et al. Experimental research on TECA-I bioartificial liver support system to treat canines with acute liver failure[J]. World J Gastroenterol, 2001, 7(5): 706-709. DOI: 10.3748/wjg.v7.i5.706
[38]	ZHAN M. A comparative study of 85% liver resection and drug-induced acute liver failure in rats[D]. Nanchang: Nanchang University, 2009. (in Chinese) 占敏. 切除85%肝与药物诱导大鼠急性肝衰竭模型的对比研究[D]. 南昌: 南昌大学, 2009.
[39]	CHEN Y, GAO ZQ, YANG JZ, et al. Establishment of surgical acute hepatic failure model in rats after 90% hepatectomy[J]. Chin J Hepatol, 1993, 1(1): 35-38. (in Chinese) 陈勇, 高志清, 杨继震, 等. 改良90%肝切除大鼠外科型急性肝衰模型建立[J]. 中华肝脏病杂志, 1993, 1(1): 35-38.
[40]	CAO YD, LIANG S, LI ZR, et al. Establishment and evaluation of different acute liver failure models in rabbits[J]. Prog Mod Biomed, 2009, 9(5): 846-848, 906. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX200905017.htm 曹友德, 梁珊, 李灼日, 等. 兔不同急性肝衰竭模型的建立与评价[J]. 现代生物医学进展, 2009, 9(5): 846-848, 906. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX200905017.htm
[41]	YTREBØ LM, NEDREDAL GI, LANGBAKK B, et al. An experimental large animal model for the assessment of bioartificial liver support systems in fulminant hepatic failure[J]. Scand J Gastroenterol, 2002, 37(9): 1077-1088. DOI: 10.1080/003655202320378293
[42]	YUASA T, YAMAMOTO T, RIVAS-CARRILLO JD, et al. Laparoscopy-assisted creation of a liver failure model in pigs[J]. Cell Transplant, 2008, 17(1-2): 187-193. DOI: 10.3727/000000008783906973
[43]	TUNON MJ, SANCHEZ-CAMPOS S, GARCIA-FERRERAS J, et al. Rabbit hemorrhagic viral disease: Characterization of a new animal model of fulminant liver failure[J]. J Lab Clin Med, 2003, 141(4): 272-278. DOI: 10.1067/mlc.2003.30
[44]	CRESPO I, SAN-MIGUEL B, SÁNCHEZ DI, et al. Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin[J]. J Pineal Res, 2016, 61(2): 168-176. DOI: 10.1111/jpi.12335
[45]	YAMAUCHI K, YAMAGUCHI N, FURUKAWA T, et al. A murine model of acute liver injury induced by human monoclonal autoantibody[J]. Hepatology, 2005, 42(1): 149-155. DOI: 10.1002/hep.20726
[46]	TERBLANCHE J, HICKMAN R. Animal models of fulminant hepatic failure[J]. Dig Dis Sci, 1991, 36: 770-774. DOI: 10.1007/BF01311235
[47]	FOURNEAU I, PIRENNE J, ROSKAMS T, et al. An improved model of acute liver failure based on transient ischemia of the liver[J]. Arch Surg, 2000, 135(10): 1183-1189. DOI: 10.1001/archsurg.135.10.1183
[48]	NEWSOME PN, PLEVRIS JN, NELSON LJ, et al. Animal models of fulminant hepatic failure: A critical evaluation[J]. Liver Transpl, 2000, 6(1): 21-31. http://europepmc.org/abstract/MED/10648574

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (1600) PDF downloads(256)

Research advances in animal models of acute liver failure

DOI: 10.3969/j.issn.1001-5256.2021.01.045

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Research advances in animal models of acute liver failure

DOI: 10.3969/j.issn.1001-5256.2021.01.045

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content