Research advances in animal models of acute liver failure

Fuli LONG; Yong LIN; Ziming PENG; Feng FENG; Jianling ZHANG; Dewen MAO; Ailing WEI

doi:10.3969/j.issn.1001-5256.2021.01.045

Volume 37 Issue 1

Jan. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(1): 204-208

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Research advances in animal models of acute liver failure

DOI: 10.3969/j.issn.1001-5256.2021.01.045

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530200, China
2.
Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
3.
College of Adult Education, Guangxi University of Chinese Medicine, Nanning 530001, China

Received Date: 2020-06-20
Accepted Date: 2020-08-08
Published Date: 2021-01-20

Abstract

Abstract

Acute liver failure is a serious and complex liver disease with a high short-term mortality rate. Its pathogenesis remains unknown and there is still a lack of effective drugs. Animal models play an important role in further revealing the pathogenesis of acute liver failure and the therapeutic mechanism of drugs, and the selection of experimental animals and preparation methods is the key to the effective implementation of research. This article summarizes the commonly used and new animal models of acute liver failure in recent years and the corresponding preparation methods and divides the animal models of acute liver failure into following four categories: chemical drug model, surgical model, infection model, and other models. Meanwhile, the above models are evaluated based on Terblanche and Hickman evaluation criteria for liver failure models, hoping to provide a reference for model selection and evaluation in basic research on this disease.
- Liver Failure, Acute,
- Disease Models, Animal,
- Modeling Method

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References

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Research advances in animal models of acute liver failure

DOI: 10.3969/j.issn.1001-5256.2021.01.045

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