Role of interleukin-1β in the pathogenesis of alcoholic liver disease

Hui QUAN; Yuyong JIANG

doi:10.3969/j.issn.1001-5256.2021.05.053

Volume 37 Issue 5

May 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(5): 1226-1228

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Role of interleukin-1β in the pathogenesis of alcoholic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.05.053

Hui QUAN^{1, 2},
Yuyong JIANG^{1
,
,}

1.
Department of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100011, China
2.
Graduate School of Beijing University of Chinese Medicine, Beijing100011, China

Received Date: 2020-10-11
Accepted Date: 2020-12-14
Published Date: 2021-05-20

Abstract

Abstract

Alcoholic liver disease (ALD) has become the second largest liver disease after viral liver disease in China. Chronic alcohol exposure increases the production of proinflammatory factors including interleukin-1β (IL-1β), which is closely associated with the main symptoms of alcoholic hepatitis such as pyrexia and elevated white blood cell count. This article introduces the production and function of IL-1β; in ALD, it promotes hepatic steatosis and inflammation by acting on liver parenchymal cells and nonparenchymal cells and accelerates liver fibrosis by regulating the proliferation of hepatic stellate cells. It is pointed out that interference with the IL-1β pathway may become one of the treatment strategies for ALD in the future.
- Liver Diseases, Alcoholic,
- Fatty Liver, Alcoholic,
- Interleukin-1beta

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References(35)

References

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Role of interleukin-1β in the pathogenesis of alcoholic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.05.053

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Role of interleukin-1β in the pathogenesis of alcoholic liver disease

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