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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 7
Jul.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(7): 1609-1613

The change in the prevalence of fatty liver disease and related influencing factors among Karamay residents in 2009-2016 and related influencing factors

DOI: 10.3969/j.issn.1001-5256.2021.07.026
  • 1a.

    Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China

  • 1b.

    Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China

  • 2a.

    Medical Examination Center, Karamay Central Hospital, Karamay, Xinjiang 834099, China

  • 2b.

    Department of Gastroenterology, Karamay Central Hospital, Karamay, Xinjiang 834099, China

  • 3.

    Department of Gastroenterology, Pudong Hospital Affiliated to Fudan University, Shanghai 201399, China

Research funding:

Wang Baoen Liver Fibrosis Research Foundation of Chinese Foundation for Hepatitis Prevention and Control (WBE20181025);

Talents Training Program of Pudong Hospital affiliated to Fudan University (YJRCJJ201801);

Shannxi Province General Projects-Social Development (2020SF-297);

National Key Research and Development Program of China during the 13th Five-Year Plan Period (2018YFC1311504)

  • Received Date: 2020-12-07
  • Accepted Date: 2021-01-26
  • Published Date: 2021-07-20
    Abstract
  •   Objective  To investigate the change in the prevalence rate of fatty liver disease (FLD) and related influencing factors among individuals undergoing physical examination in Karamay Central Hospital from 2009 to 2016, and to provide a reference for the prevention and treatment of FLD.  Methods  Abdominal ultrasound (230 330 cases) was performed in Karamay Central Hospital from January 2009 to December 2016, and related data were used to analyze the change in the prevalence rate of FLD and compare the difference between male and female individuals. A total of 33 195 individuals who underwent physical examination in 2016 and had complete data of age, body mass index (BMI), fasting blood glucose, and triglyceride were selected to analyze the prevalence rate of FLD among the individuals with different ages, BMIs, and sexes. A multivariate logistic regression analysis was used to investigate independent influencing factors for the development of FLD. The chi-square test was used for comparison of categorical data between groups; the t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups.  Results  From 2009 to 2016, the prevalence rate of FLD increased from 19.4% to 31.9% among the individuals who underwent physical examination in Karamay Central Hospital (P < 0.001); the prevalence rate increased from 22.8% to 39.5% among male individuals (P < 0.001), and the prevalence rate increased from 11.8% to 21.6% among female individuals (P < 0.001), suggesting that male individuals had a significantly higher prevalence rate than female individuals in each year (P < 0.001). Among the individuals who underwent physical examination in 2016, the prevalence rate of FLD was 26.1% in 17 848 young individuals, 37.3% in 10 017 middle-aged individuals, and 41.7% in 5330 elderly individuals (P < 0.001); the young and middle-aged male individuals had a significantly higher risk of FLD than the female individuals in the same age group (both P < 0.001), and the elderly male individuals had a significantly lower risk of FLD than the female individuals in the same age group (P=0.022). There were 865 individuals with emaciation, 13 510 with normal body weight, 12 755 with overweight, and 6065 with obesity, with a prevalence rate of FLD of 0.8%, 9.5%, 39.6%, and 70.6%, respectively (P < 0.001), and the stratified analysis based on BMI showed that male individuals had a significantly higher prevalence rate of FLD than females individuals (P < 0.05). The multivariate logistic regression analysis showed that age, sex, BMI, systolic pressure, diastolic pressure, alanine aminotransferase, total bilirubin, fasting blood glucose, triglyceride, total cholesterol, and serum uric acid were independent influencing factors for FLD (all P < 0.05).  Conclusion  There is a rapid increase in the prevalence rate of FLD among the residents of Karamay, and there are various risk factors. It is recommended to strengthen policy intervention, provide public education, screen out the high-risk population, and implement preventive and treatment measures as early as possible, so as to reduce related medical burden.

     

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