Research advances in the role of the glucocorticoid-induced tumor necrosis factor receptor-related protein and its ligand in liver diseases

Yu HE; Jidong JIA; Ping WANG

doi:10.3969/j.issn.1001-5256.2021.07.051

Volume 37 Issue 7

Jul. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(7): 1718-1723

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Research advances in the role of the glucocorticoid-induced tumor necrosis factor receptor-related protein and its ligand in liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.07.051

Yu HE^a,
Jidong JIA^{a, b},
Ping WANG^{a
,
,}

a.
Liver Disease Center, Beijing Friendship Hospital, Capital Medical University; Beijing 100050, China
b.
Beijing Clinical Institute, Beijing Friendship Hospital, Capital Medical University; Beijing 100050, China

Research funding:

Chinese Foundation for Hepatitis Prevention and Control of the Wcay Baoen Liver Fibrosis Foundation (2019073);

National Science and Technology Major Special Project for New Drug Development (2018ZX09201016)

Received Date: 2020-12-24
Accepted Date: 2021-02-15
Published Date: 2021-07-20

Abstract

Abstract

Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a member of the tumor necrosis factor receptor superfamily, and after it specifically binds to GITR ligand (GITRL), the downstream signals mediated by them can not only serve as a costimulatory molecule to promote the proliferation and cytokine secretion of effector T cells, but also affect the proliferation of regulatory T cells and inhibit the function of effector T cells, thereby regulating the inflammatory response and tumor cell-killing effect of effector T cells. GITRL is mainly expressed in antigen- presenting cells and has an intracellular domain, and the binding of GITRL to GITR can affect the function of antigen-presenting cells via receptor/ligand reverse signaling. In liver diseases, GITRL/GITR signal is not only involved in immune rejection after liver transplantation and gene therapy, but also associated with the formation of tumor immune microenvironment and the immune escape of tumor. Further studies are needed to explore the role of GITRL/GITR in the development and progression of other liver diseases.
- Liver Diseases,
- Glucocorticoid-Induced TNFR-Related Protein,
- Glucocorticoid-Induced TNFR-Related Ligand,
- Immunomodulation,
- T-Lymphocytes, Regulatory

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References

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Research advances in the role of the glucocorticoid-induced tumor necrosis factor receptor-related protein and its ligand in liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.07.051

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