Molecular heterogeneity of hepatocellular carcinoma and its precise treatment in clinical practice

Qiang ZOU; Jun WANG; Liangzhi WEN; Bin WANG; Yi ZHANG

doi:10.3969/j.issn.1001-5256.2021.08.006

Volume 37 Issue 8

Aug. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(8): 1765-1769

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Molecular heterogeneity of hepatocellular carcinoma and its precise treatment in clinical practice

DOI: 10.3969/j.issn.1001-5256.2021.08.006

Qiang ZOU^{1, 2},
Jun WANG¹,
Liangzhi WEN¹,
Bin WANG^{1
,
,},
Yi ZHANG^{2
,
,}

1.
Department of Gastroenterology, Daping Hospital, Army Medical University, Chongqing 400042, China
2.
Department of Hepatobiliary Surgery, Chongqing University Cancer Hospital, Chongqing 400042, China

Research funding:

National Natural Science Foundation of China (81872027);

National Natural Science Foundation of China (82002585);

Scientific Research Project of Army Medical University (2019XQY19)

Received Date: 2021-05-28
Accepted Date: 2021-05-28
Published Date: 2021-08-20

Abstract

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and high molecular heterogeneity of HCC has caused the limitations in clinical efficacy; therefore, it is of great importance to explore its heterogeneity based on molecular classification and develop individualized diagnosis and treatment strategies. Various high-throughput sequencing techniques and multi-omics techniques in recent years have helped to establish multiple molecular classification systems, which gives us a deeper understanding of the molecular heterogeneity of HCC. This article summarizes the molecular classifications of HCC and discusses their association with clinicopathological features. This article also analyzes the new targets for molecular targeted therapy and immunotherapy and proposes new ideas for precise diagnosis and individualized treatment of HCC.
- Carcinoma, Hepatocellular,
- Genetic Heterogeneity,
- Therapeutics

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References

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Molecular heterogeneity of hepatocellular carcinoma and its precise treatment in clinical practice

DOI: 10.3969/j.issn.1001-5256.2021.08.006

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Molecular heterogeneity of hepatocellular carcinoma and its precise treatment in clinical practice

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