[1] |
ZHONG L, D'URSO A, TOIBER D, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha[J]. Cell, 2010, 140(2): 280-293. DOI: 10.1016/j.cell.2009.12.041.
|
[2] |
KIM HG, HUANG M, XIN Y, et al. The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice[J]. J Hepatol, 2019, 71(5): 960-969. DOI: 10.1016/j.jhep.2019.06.019.
|
[3] |
KIM HS, XIAO C, WANG RH, et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis[J]. Cell Metab, 2010, 12(3): 224-236. DOI: 10.1016/j.cmet.2010.06.009.
|
[4] |
SEBASTIÁN C, ZWAANS BM, SILBERMAN DM, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism[J]. Cell, 2012, 151(6): 1185-1199. DOI: 10.1016/j.cell.2012.10.047.
|
[5] |
MOSTOSLAVSKY R, CHUA KF, LOMBARD DB, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6[J]. Cell, 2006, 124(2): 315-329. DOI: 10.1016/j.cell.2005.11.044.
|
[6] |
ELHANATI S, KANFI Y, VARVAK A, et al. Multiple regulatory layers of SREBP1/2 by SIRT6[J]. Cell Rep, 2013, 4(5): 905-912. DOI: 10.1016/j.celrep.2013.08.006.
|
[7] |
BLANDER G, GUARENTE L. The Sir2 family of protein deacetylases[J]. Annu Rev Biochem, 2004, 73: 417-435. DOI: 10.1146/annurev.biochem.73.011303.073651.
|
[8] |
FLICK F, LUSCHER B. Regulation of sirtuin function by posttranslational modifications[J]. Front Pharmacol, 2012, 3: 29. DOI: 10.3389/fphar.2012.00029.
|
[9] |
HERSKOVITS AZ, GUARENTE L. Sirtuin deacetylases in neurodegenerative diseases of aging[J]. Cell Res, 2013, 23(6): 746-758. DOI: 10.1038/cr.2013.70.
|
[10] |
MAHLKNECHT U, HO AD, VOELTER-MAHLKNECHT S. Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene[J]. Int J Oncol, 2006, 28(2): 447-456.
|
[11] |
PAN PW, FELDMAN JL, DEVRIES MK, et al. Structure and biochemical functions of SIRT6[J]. J Biol Chem, 2011, 286(16): 14575-14587. DOI: 10.1074/jbc.M111.218990.
|
[12] |
JIANG H, KHAN S, WANG Y, et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine[J]. Nature, 2013, 496(7443): 110-113. DOI: 10.1038/nature12038.
|
[13] |
GUO L, WANG D, OUYANG X, et al. Recent advances in HBV reactivation research[J]. Biomed Res Int, 2018, 2018: 2931402. DOI: 10.1155/2018/2931402.
|
[14] |
DU L, MA Y, LIU M, et al. Peroxisome proliferators activated receptor (PPAR) agonists activate hepatitis B virus replication in vivo[J]. Virol J, 2017, 14(1): 96. DOI: 10.1186/s12985-017-0765-x.
|
[15] |
XIE BJ, GUO JJ, ZHANG Y, et al. Peroxisome proliferator-activated receptor alpha regulates HBV minichromosome remodeling and viral replication[J]. J Chongqing Med Univ, 2017, 42(7): 795-802. DOI: 10.13406./j.cnki.cyxb.001349.
谢冰珏, 郭进军, 张燕, 等. 过氧化物酶体增殖物激活受体α(PPARα)调控HBV微染色体重塑与病毒复制[J]. 重庆医科大学学报, 2017, 42(7): 795-802. DOI: 10.13406./j.cnki.cyxb.001349.
|
[16] |
GUIDOTTI LG, EGGERS CM, RANEY AK, et al. In vivo regulation of hepatitis B virus replication by peroxisome proliferators[J]. J Virol, 1999, 73(12): 10377-10386. DOI: 10.1128/JVI.73.12.10377-10386.1999.
|
[17] |
WU XT, YANG J, WANG XJ, et al. Anti-HBV effect identification of antisense oligodeoxynucleotide targeting PPARα[J]. Lett Biotech, 2011, 22(6): 773-776. DOI: 10.3969/j.issn.1009-0002.2011.06.005.
吴小桃, 杨静, 王学军, 等. 抑制核转录因子PPARα的反义寡核苷酸的抗乙型肝炎病毒活性研究[J]. 生物技术通讯, 2011, 22(6): 773-776. DOI: 10.3969/j.issn.1009-0002.2011.06.005.
|
[18] |
JIANG H, CHENG ST, REN JH, et al. SIRT6 inhibitor, OSS_128167 restricts hepatitis B virus transcription and replication through targeting transcription factor peroxisome proliferator-activated receptors α[J]. Front Pharmacol, 2019, 10: 1270. DOI: 10.3389/fphar.2019.01270.
|
[19] |
JIANG H. SIRT6 inhibitor, OSS_128167 effect on hepatitis B virus replication and mechanism of research[D]. Chongqing: Chongqing Medical University, 2020.
姜慧. SIRT6抑制剂, OSS_128167对HBV复制的影响及机制研究[D]. 重庆: 重庆医科大学, 2020.
|
[20] |
YKI-JARVINEN H. Diagnosis of nonalcoholic fatty liver disease (NAFLD)[J]. Duodecim, 2016, 132(22): 2099-2106.
|
[21] |
BUZZETTI E, PINZANI M, TSOCHATZIS EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)[J]. Metabolism, 2016, 65(8): 1038-1048. DOI: 10.1016/j.metabol.2015.12.012.
|
[22] |
ZHOU Q, SU J, JI MY. Progress in the treatment of nonalcoholic fatty liver disease[J]. China Med Herald, 2020, 17(6): 26-29. DOI: 10.3969/j.issn.1000-484X.2019.13.023.
周谦, 苏娟, 季梦遥. 非酒精性脂肪性肝病的治疗研究进展[J]. 中国医药导报, 2020, 17(6): 26-29. DOI: 10.3969/j.issn.1000-484X.2019.13.023.
|
[23] |
KANFI Y, NAIMAN S, AMIR G, et al. The sirtuin SIRT6 regulates lifespan in male mice[J]. Nature, 2012, 483(7388): 218-221. DOI: 10.1038/nature10815.
|
[24] |
PENROSE H, HELLER S, CABLE C, et al. Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6[J]. Biochem Biophys Res Commun, 2016, 469(3): 370-376. DOI: 10.1016/j.bbrc.2015.11.119.
|
[25] |
XIAO C, KIM HS, LAHUSEN T, et al. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice[J]. J Biol Chem, 2010, 285(47): 36776-36784. DOI: 10.1074/jbc.M110.168039.
|
[26] |
XIONG X, WANG G, TAO R, et al. Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells[J]. Diabetologia, 2016, 59(1): 151-160. DOI: 10.1007/s00125-015-3778-2.
|
[27] |
XIONG X, SUN X, WANG Q, et al. SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis[J]. J Endocrinol, 2016, 231(2): 159-165. DOI: 10.1530/JOE-16-0317.
|
[28] |
CALIGIURI A, GENTILINI A, MARRA F. Molecular pathogenesis of NASH[J]. Int J Mol Sci, 2016, 17(9)DOI: 10.3390/ijms17091575.
|
[29] |
ZHANG N, LI Z, MU W, et al. Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling[J]. Cell Cycle, 2016, 15(7): 1009-1018. DOI: 10.1080/15384101.2016.1152427.
|
[30] |
XIAO C, WANG RH, LAHUSEN TJ, et al. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice[J]. J Biol Chem, 2012, 287(50): 41903-41913. DOI: 10.1074/jbc.M112.415182.
|
[31] |
DOU HX, ZHANG DJ. Advances in the molecular pathogenesis of alcoholic liver disease[J]. Genom Appl Biol, 2016, 35(7): 1643-1647. DOI: 10.13417/j.gab.035.001643.
窦慧馨, 张得钧. 酒精性肝病分子发病机制研究进展[J]. 基因组学与应用生物学, 2016, 35(7): 1643-1647. DOI: 10.13417/j.gab.035.001643.
|
[32] |
KOURKOUMPETIS T, SOOD G. Pathogenesis of alcoholic liver disease: An update[J]. Clin Liver Dis, 2019, 23(1): 71-80. DOI: 10.1016/j.cld.2018.09.006.
|
[33] |
ZENG T, ZHANG CL, SONG FY, et al. CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway[J]. PLoS One, 2014, 9(6): e98658. DOI: 10.1371/journal.pone.0098658.
|
[34] |
XIN SL. SIRT6 alleviates nonalcoholic fatty liver disease by up-regulating PPAR-α pathway and reversing senescence of hepatocytes[D]. Wuhan: Huazhong University of Science and Technology, 2019.
辛晟梁. SIRT6通过上调PPAR-α及阻遏肝细胞衰老改善非酒精性脂肪性肝病[D]. 武汉: 华中科技大学, 2019.
|
[35] |
HIGASHI T, FRIEDMAN SL, HOSHIDA Y. Hepatic stellate cells as key target in liver fibrosis[J]. Adv Drug Deliv Rev, 2017, 121: 27-42. DOI: 10.1016/j.addr.2017.05.007.
|
[36] |
CAJA L, DITURI F, MANCARELLA S, et al. TGF-β and the tissue microenvironment: Relevance in fibrosis and cancer[J]. Int J Mol Sci, 2018, 19(5): 1294. DOI: 10.3390/ijms19051294.
|
[37] |
ZHANG Y, CUI Y, WANG XL, et al. PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats[J]. Cytokine, 2015, 75(1): 127-135. DOI: 10.1016/j.cyto.2015.05.031.
|
[38] |
ZHANG J, LI Y, LIU Q, et al. Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells[J]. Hepatology, 2021, 73(3): 1140-1157. DOI: 10.1002/hep.31418.
|
[39] |
ZHONG X, HUANG M, KIM HG, et al. SIRT6 protects against liver fibrosis by deacetylation and suppression of SMAD3 in hepatic stellate cells[J]. Cell Mol Gastroenterol Hepatol, 2020, 10(2): 341-364. DOI: 10.1016/j.jcmgh.2020.04.005.
|
[40] |
MAITY S, MUHAMED J, SARIKHANI M, et al. Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice[J]. J Biol Chem, 2020, 295(2): 415-434. DOI: 10.1074/jbc.RA118.007212.
|
[41] |
TIAN K, CHEN P, LIU Z, et al. Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling[J]. Oncotarget, 2017, 8(37): 61011-61024. DOI: 10.18632/oncotarget.17723.
|
[42] |
ZHANG Q, TU W, TIAN K, et al. Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts[J]. J Cell Biochem, 2019, 120(1): 93-104. DOI: 10.1002/jcb.27128.
|
[43] |
HEIMBACH JK, KULIK LM, FINN RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma[J]. Hepatology, 2018, 67(1): 358-380. DOI: 10.1002/hep.29086.
|
[44] |
ZHAO Y, ZHANG YH. Immunosuppression in hepatocellular carcinoma and immunomodulation in treatment[J]. Chin J Immunol, 2019, 35(13): 1643-1645, 1650. DOI: 10.3969/j.issn.1000-484X.2019.13.023.
赵艳, 张永宏. 肝细胞癌中的免疫抑制与治疗中的免疫调节[J]. 中国免疫学杂志, 2019, 35(13): 1643-1645, 1650. DOI: 10.3969/j.issn.1000-484X.2019.13.023.
|
[45] |
WAHID B, ALI A, RAFIQUE S, et al. New insights into the epigenetics of hepatocellular carcinoma[J]. Biomed Res Int, 2017, 2017: 1609575. DOI: 10.1155/2017/1609575.
|
[46] |
de SOUZA C, CHATTERJI BP. HDAC Inhibitors as novel anti-cancer therapeutics[J]. Recent Pat Anticancer Drug Discov, 2015, 10(2): 145-162. DOI: 10.2174/1574892810666150317144511.
|
[47] |
MIN L, JI Y, BAKIRI L, et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin[J]. Nat Cell Biol, 2012, 14(11): 1203-1211. DOI: 10.1038/ncb2590.
|
[48] |
HUANG Z, ZHAO J, DENG W, et al. Identification of a cellularly active SIRT6 allosteric activator[J]. Nat Chem Biol, 2018, 14(12): 1118-1126. DOI: 10.1038/s41589-018-0150-0.
|
[49] |
van METER M, MAO Z, GORBUNOVA V, et al. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells[J]. Cell Cycle, 2011, 10(18): 3153-3158. DOI: 10.4161/cc.10.18.17435.
|
[50] |
MING M, HAN W, ZHAO B, et al. SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer[J]. Cancer Res, 2014, 74(20): 5925-5933. DOI: 10.1158/0008-5472.CAN-14-1308.
|
[51] |
HAN LL, JIA L, WU F, et al. Sirtuin6 (SIRT6) promotes the EMT of hepatocellular carcinoma by stimulating autophagic degradation of E-cadherin[J]. Mol Cancer Res, 2019, 17(11): 2267-2280. DOI: 10.1158/1541-7786.MCR-19-0321.
|
[52] |
XIA YQ, HUA RJ, JUAN C, et al. SIRT6 depletion sensitizes human hepatoma cells to chemotherapeutics by downregulating MDR1 expression[J]. Front Pharmacol, 2018, 9: 194. DOI: 10.3389/fphar.2018.00194.
|