Pathogenesis of drug-induced liver injury: Current understanding and future needs

Yuecheng YU; Chengwei CHEN

doi:10.3969/j.issn.1001-5256.2021.11.003

Volume 37 Issue 11

Nov. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(11): 2515-2524

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Pathogenesis of drug-induced liver injury: Current understanding and future needs

DOI: 10.3969/j.issn.1001-5256.2021.11.003

Yuecheng YU^{1
,
,},
Chengwei CHEN²

1.
Department of Infectious Diseases and Center of Liver Diseases, General Hospital of Eastern Theater Command, Nanjing 210002, China
2.
Liver Diseases Research Center, The 905 Hospital Affiliated to Navy Medical University, Shanghai 200235, China

Received Date: 2021-09-15
Accepted Date: 2021-09-15
Published Date: 2021-11-20

Abstract

Abstract

The risk factors for drug-induced liver injury (DILI) involve host factors (including general non-genetic factors and idiosyncratic genetic and immune factors), drug-related factors, and environmental factors. The pathogenesis of DILI can be classified as intrinsic (or direct) hepatotoxicity, idiosyncratic hepatotoxicity, and indirect hepatotoxicity, as well as tumorigenicity and carcinogenicity of some drugs to the liver. The pathogenesis of different types of hepatotoxicity not only has significant differences, but also has internal correlation at multiple links. The three-step model centered on mitochondrial permeability transition (MPT) and a two-stage model with liver cell regeneration and liver tissue repair capacity as the determinants of different outcomes display the mechanism progress of DILI from different perspectives. Clarification of the complex pathogenesis of DILI needs long-term collection of clinical cases and systematic studies, which is of great significance for the scientific prevention, diagnosis, and treatment of DILI.
- Chemical and Drug-Induced Liver Injury,
- Risk Factors,
- Pathogenesis

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References

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Pathogenesis of drug-induced liver injury: Current understanding and future needs

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