Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

Weizhao TONG; wei LIU; Guoxin HU

doi:10.3969/j.issn.1001-5256.2021.11.038

Volume 37 Issue 11

Nov. 2021

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Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.11.038

Weizhao TONG^{1, 2},
wei LIU³,
Guoxin HU^{1
,
,}

1.
Department of Infectious Diseases, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China
2.
Shantou University Medical College, Shantou, Guangdong 515041, China
3.
Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center; Shenzhen Key Laboratory for Neuronal Structural Biology, Shenzhen 518036, China

Research funding:

National Natural Science Foundation of China (81473473)

Received Date: 2021-07-30
Accepted Date: 2021-08-31
Published Date: 2021-11-20

Abstract

Abstract

Erythropoietin-producing hepatocyte (Eph) receptors are the largest subgroup of the receptor tyrosine kinase family and are involved in the physiological processes such as embryonic development, angiogenesis, and axon guidance. Recent studies have shown that Eph receptors are overexpressed in liver fibrosis and hepatocellular carcinoma tissues and play an important role in the growth, invasion, and metastasis of hepatocellular carcinoma. This article explores the mechanism of action of Eph receptors in liver fibrosis and hepatocellular carcinoma and points out that Eph receptors may be important molecules in the development and progression of liver fibrosis and hepatocellular carcinoma.
- Erythropoietin Producing Hepatocyte Receptor,
- Liver Cirrhosis,
- Carcinoma, Hepatocellular

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References(38)

References

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Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.11.038

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Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

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