Impact of nonalcoholic fatty liver disease on intestinal immune cells

Yalan LEI; Jian BI; Jingwei MAO

doi:10.3969/j.issn.1001-5256.2021.11.039

Volume 37 Issue 11

Nov. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(11): 2667-2671

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Impact of nonalcoholic fatty liver disease on intestinal immune cells

DOI: 10.3969/j.issn.1001-5256.2021.11.039

Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China

Research funding:

National Natural Science Foundation of China (81500402);

National Natural Science Foundation of Liaoning, China (20180530055)

Received Date: 2021-03-24
Accepted Date: 2021-04-26
Published Date: 2021-11-20

Abstract

Abstract

Nonalcoholic fatty liver disease (NAFLD) interacts with the intestinal immune system due to enterohepatic circulation and immune cell recruitment and recirculation. Intestinal immune imbalance promotes liver inflammation and fibrosis in the process of NAFLD, and meanwhile, NAFLD can cause disorders in the number and function of immune cells in the liver and intestinal tract. This article mainly elaborates on the impact of NAFLD on intestinal immune cells and briefly summarizes the new treatment methods for NAFLD targeting at intestinal immune cells, in order to provide a new understanding of the pathogenesis and treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Enterohepatic Circulation,
- Macrophages,
- Dendritic Cells,
- Lymphocytes

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References

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Impact of nonalcoholic fatty liver disease on intestinal immune cells

DOI: 10.3969/j.issn.1001-5256.2021.11.039

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Impact of nonalcoholic fatty liver disease on intestinal immune cells

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