Protect the portal vein: From pathophysiology to clinical decision making

Zhiyin HUANG; Jinhang GAO

doi:10.3969/j.issn.1001-5256.2021.12.003

Volume 37 Issue 12

Dec. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(12): 2760-2763

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Protect the portal vein: From pathophysiology to clinical decision making

DOI: 10.3969/j.issn.1001-5256.2021.12.003

Zhiyin HUANG^a,
Jinhang GAO^{a, b
,
,}

a.
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Laboratory of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, China

Research funding:

National Nature Science Foundation of China (81873584);

National Nature Science Foundation of China (82000613);

National Nature Science Foundation of China (82170623);

National Nature Science Foundation of China (82170625);

Chengdu Science and Technology Bureau (2017-CY02-00023-GX)

Received Date: 2021-08-04
Accepted Date: 2021-08-31
Published Date: 2021-12-20

Abstract

Abstract

The portal vein system is the main blood supply system of the liver, and damage to the portal vein system caused by cirrhotic portal hypertension may be the second hit to the liver. Protection of the portal vein will ensure sufficient blood supply of the liver and maintain its structure and function. Starting from the physiological structure and pathological changes of the portal vein, this article elaborates on the adverse effect of portal hypertension on the liver from the three new perspectives of thrombosis of the portal system, abnormal angiogenesis, and disturbance of hepatic sinusoidal homeostasis. It is suggested to change the current status of passive treatment of portal hypertension complications and encourage scientific exploration to reduce portal hypertension from multiple angles as early as possible to avoid repeated endoscopic devascularization of collateral circulation and splenectomy, so as to reduce various factors for the damage of the portal system, maintain the homeostasis of the portal system, and protect the liver.
- Portal Hypertension, Portal Vein,
- Liver Cirrhosis,
- Venous Thrombosis,
- Neovascularization, Pathologic

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References(28)

References

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Protect the portal vein: From pathophysiology to clinical decision making

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Protect the portal vein: From pathophysiology to clinical decision making

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