Application of pathological indicators based on liver biopsy in the diagnosis of cirrhotic portal hypertension

Yajie XU; Wenzheng YOU; Wanlei REN; Quanhe LONG; Xiangjun JIANG; Doudou HU

doi:10.3969/j.issn.1001-5256.2021.12.042

Volume 37 Issue 12

Dec. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(12): 2935-2938

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Application of pathological indicators based on liver biopsy in the diagnosis of cirrhotic portal hypertension

DOI: 10.3969/j.issn.1001-5256.2021.12.042

Yajie XU^{1, 2a},
Wenzheng YOU^2b,
Wanlei REN³,
Quanhe LONG^2c,
Xiangjun JIANG^2a,
Doudou HU^{2a
,
,}

1.
Graduate School of Dalian Medical University, Dalian, Liaoning 116044, China
2a.
Second Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong 266000, China
2b.
Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong 266000, China
2c.
Department of General Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266000, China
3.
First Department of Traditional Chinese Medicine, Qingdao Central Hospital Affiliated to Qingdao University, Qingdao, Shandong 266042, China

Research funding:

National Natural Science Foundation of China Young Scientist Fund (81800543)

Received Date: 2021-05-12
Accepted Date: 2021-05-20
Published Date: 2021-12-20

Abstract

Abstract

Hepatic venous pressure gradient (HVPG) is the "gold standard" for diagnosing portal hypertension and determining its severity, but its wide clinical application is limited due to its invasiveness and difficulties in operation. The replacement of HVPG by noninvasive methods has become a research hotspot in recent years; however, the accuracy of the existing serological and imaging methods remains to be discussed, and such methods cannot completely replace HVPG in clinical practice. Liver biopsy has been widely used in clinical practice for many years and is still an indispensable method for the diagnosis of some liver diseases. Recent studies have found that several pathological indicators after liver biopsy, such as collagen area, fibrous septal thickness, nodule size, microvascular density, and density and area of bile ducts and lymphatic vessels, can not only judge the severity of liver fibrosis, but also have a good correlation with portal venous pressure, which provides new ideas for diagnosing cirrhotic portal hypertension and evaluating the severity of portal hypertension.
- Liver Cirrhosis,
- Hypertension, Portal,
- Biopsy, Needle,
- Diagnosis

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References(48)

References

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Application of pathological indicators based on liver biopsy in the diagnosis of cirrhotic portal hypertension

DOI: 10.3969/j.issn.1001-5256.2021.12.042

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Application of pathological indicators based on liver biopsy in the diagnosis of cirrhotic portal hypertension

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