Research advances in improving the prognosis of recipients of fatty liver transplantation

Xing DAI; Ben GAO; Jiang LI

doi:10.3969/j.issn.1001-5256.2021.12.049

Volume 37 Issue 12

Dec. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(12): 2967-2971

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Research advances in improving the prognosis of recipients of fatty liver transplantation

DOI: 10.3969/j.issn.1001-5256.2021.12.049

The First Central Clinical College of Tianjin Medical University, Tianjin 300110, China

Research funding:

National Natural Science Foundation of China(General Program) (82072219)

Received Date: 2021-05-08
Accepted Date: 2021-05-31
Published Date: 2021-12-20

Abstract

Abstract

With the increasing demand for liver donors, more and more marginal donors have been used. How to use fatty liver grafts has become a new issue that physicians in the department of liver transplantation must face. Compared with the normal donor liver, fatty liver grafts have high incidence of postoperative complications and increase the difficulty of clinical cure. This review describes the measures to improve the prognosis of recipients of fatty liver transplantation, and points out that these measures can reduce the risk of fatty liver transplantation and thus increase the utilization of fatty liver grafts.
- Fatty Liver,
- Liver Transplantation,
- Transplant Recipients,
- Prognosis

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References(34)

References

[1]	AHMED EA, EL-BADRY AM, MOCCHEGIANI F, et al. Impact of graft steatosis on postoperative complications after liver transplantation[J]. Surg J (N Y), 2018, 4(4): e188-188e196. DOI: 10.1055/s-0038-1675236.
[2]	CROOME KP, MATHUR AK, MAO S, et al. Perioperative and long-term outcomes of utilizing donation after circulatory death liver grafts with macrosteatosis: A multicenter analysis[J]. Am J Transplant, 2020, 20(9): 2449-2456. DOI: 10.1111/ajt.15877.
[3]	ZHANG QY, ZHANG QF, ZHANG DZ. The impact of steatosis on the outcome of liver transplantation: A Meta-analysis[J]. Biomed Res Int, 2019, 2019: 3962785. DOI: 10.1155/2019/3962785.
[4]	DONG YR, LIU M, MA Y. To investigate the value of fatty liver donor liver in liver transplatation[J]. Chin J CT and MRI, 2016, 14(12): 88-89. DOI: 4.10.3969/j.issn.1672-5131.2016.12.030. 董玉茹, 刘勉, 马毅. 探讨脂肪肝供肝在肝脏移植中的价值[J]. 中国CT和MRI杂志, 2016, 14(12): 88-89. DOI: 4.10.3969/j.issn.1672-5131.2016.12.030.
[5]	de GRAAF EL, KENCH J, DILWORTH P, et al. Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the donor risk index[J]. J Gastroenterol Hepatol, 2012, 27(3): 540-546. DOI: 10.1111/j.1440-1746.2011.06844.x.
[6]	JACKSON KR, LONG J, PHILOSOPHE B, et al. Liver transplantation using steatotic grafts[J]. Clin Liver Dis (Hoboken), 2019, 14(5): 191-195. DOI: 10.1002/cld.847.
[7]	KNAAK M, GOLDARACENA N, DOYLE A, et al. Donor BMI > 30 is not a contraindication for live liver donation[J]. Am J Transplant, 2017, 17(3): 754-760. DOI: 10.1111/ajt.14019.
[8]	CROOME KP, LEE DD, CROOME S, et al. The impact of postreperfusion syndrome during liver transplantation using livers with significant macrosteatosis[J]. Am J Transplant, 2019, 19(9): 2550-2559. DOI: 10.1111/ajt.15330.
[9]	JACKSON KR, MOTTER JD, HAUGEN CE, et al. Minimizing risks of liver transplantation with steatotic donor livers by preferred recipient matching[J]. Transplantation, 2020, 104(8): 1604-1611. DOI: 10.1097/TP.0000000000003052.
[10]	TIAN DZ, JIANG WT, CHEN CY, et al. Analysis of early prognosis and risk factors of donor liver with moderate-to-severe steatosis in adult liver transplantation[J]. Ogran Transplantation, 2020, 11(6): 698-703, 736, DOI: 10.3969/j.issn.1674-7445.2020.06.008. 田大治, 蒋文涛, 陈池义, 等. 中重度脂肪变性供肝应用于成人肝移植术的早期预后及其危险因素分析[J]. 器官移植, 2020, 11(6): 698-703. DOI: 10.3969/j.issn.1674-7445.2020.06.008.
[11]	CHU MJ, DARE AJ, PHILLIPS AR, et al. Donor hepatic steatosis and outcome after liver transplantation: A systematic review[J]. J Gastrointest Surg, 2015, 19(9): 1713-1724. DOI: 10.1007/s11605-015-2832-1.
[12]	YU ZY. How to deal with fatty donor liver in liver transplantation[D]. Hangzhou: Zhejiang University, 2015. 俞志勇. 脂肪肝供肝肝移植的回顾性研究[D]. 杭州: 浙江大学, 2015.
[13]	LINARES I, HAMAR M, SELZNER N, et al. Steatosis in liver transplantation: Current limitations and future strategies[J]. Transplantation, 2019, 103(1): 78-90. DOI: 10.1097/TP.0000000000002466.
[14]	DUTKOWSKI P, SCHLEGEL A, SLANKAMENAC K, et al. The use of fatty liver grafts in modern allocation systems: Risk assessment by the balance of risk (BAR) score[J]. Ann Surg, 2012, 256(5): 861-868; discussion 868-869. DOI: 10.1097/SLA.0b013e318272dea2.
[15]	CHAVIN KD, TABER DJ, NORCROSS M, et al. Safe use of highly steatotic livers by utilizing a donor/recipient clinical algorithm[J]. Clin Transplant, 2013, 27(5): 732-741. DOI: 10.1111/ctr.12211.
[16]	WESTERKAMP AC, de BOER MT, van den BERG AP, et al. Similar outcome after transplantation of moderate macrovesicular steatotic and nonsteatotic livers when the cold ischemia time is kept very short[J]. Transpl Int, 2015, 28(3): 319-329. DOI: 10.1111/tri.12504.
[17]	WONG TC, FUNG JY, CHOK KS, et al. Excellent outcomes of liver transplantation using severely steatotic grafts from brain-dead donors[J]. Liver Transpl, 2016, 22(2): 226-236. DOI: 10.1002/lt.24335.
[18]	NACIF LS, PINHEIRO RS, ROCHA-SANTOS V, et al. Better selection criteria with prognostic factors for liver transplantation[J]. Transplant Proc, 2018, 50(3): 766-768. DOI: 10.1016/j.transproceed.2018.02.057.
[19]	MANGUS RS, DAVIS JP, LIN J. Rapid decrease in liver graft steatosis in the early post-transplant period: A blinded and randomized study[J]. Transplant Proc, 2020, 52(1): 284-288. DOI: 10.1016/j.transproceed.2019.11.024.
[20]	CAO H, SONG HL, SHEN ZY. Progress in research on donor liver preservation technology in vitro[J]. Chin J Hepatobiliary Surg, 2020, 26(3): 229-233. DOI: 10.3760/cma.j.issn.1007-8118.2020.03.005. 曹欢, 宋红丽, 沈中阳. 供肝体外保存技术的研究进展[J]. 中华肝胆外科杂志, 2020, 26(3): 229-233. DOI: 10.3760/cma.j.issn.1007-8118.2020.03.005.
[21]	GALLINAT A, HOYER DP, SOTIROPOULOS G, et al. Oxygen persufflation in liver transplantation results of a randomized controlled trial[J]. Bioengineering (Basel), 2019, 6(2). DOI: 10.3390/bioengineering6020035.
[22]	GALLINAT A, HOYER DD, KLEIN C, et al. In house oxygen persufflation of cold stored livers versus simple cold storage in extended criteria liver grafts: 5-year results of a randomized controlled clinical trial[J]. Transplantation, 2018, 102. DOI: 10.1097/01.tp.0000543139.64985.3b.
[23]	REINDERS M, van KOOTEN C, RABELINK TJ, et al. Mesenchymal stromal cell therapy for solid organ transplantation[J]. Transplantation, 2018, 102(1): 35-43. DOI: 10.1097/TP.0000000000001879.
[24]	LAI Q, RUBERTO F, PAWLIK TM, et al. Use of machine perfusion in livers showing steatosis prior to transplantation: A systematic review[J]. Updates Surg, 2020, 72(3): 595-604. DOI: 10.1007/s13304-020-00797-4.
[25]	MANZIA TM, TOTI L, QUARANTA C, et al. Liver transplantation with a normothermic machine preserved fatty nonagenarian liver: A case report[J]. Int J Surg Case Rep, 2019, 57: 163-166. DOI: 10.1016/j.ijscr.2019.03.033.
[26]	MARTINS RM, TEODORO JS, FURTADO E, et al. Recent insights into mitochondrial targeting strategies in liver transplantation[J]. Int J Med Sci, 2018, 15(3): 248-256. DOI: 10.7150/ijms.22891.
[27]	van RIJN R, KARIMIAN N, MATTON A, et al. Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death[J]. Br J Surg, 2017, 104(7): 907-917. DOI: 10.1002/bjs.10515.
[28]	LAI Q, RUBERTO F, PAWLIK TM, et al. Use of machine perfusion in livers showing steatosis prior to transplantation: A systematic review[J]. Updates Surg, 2020, 72(3): 595-604. DOI: 10.1007/s13304-020-00797-4.
[29]	KRON P, SCHLEGEL A, MANCINA L, et al. Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans[J]. J Hepatol, 2017. DOI: 10.1016/j.jhep.2017.08.028.[Online ahead of print]
[30]	PATRONO D, SURRA A, CATALANO G, et al. Hypothermic oxygenated machine perfusion of liver grafts from brain-dead donors[J]. Sci Rep, 2019, 9(1): 9337. DOI: 10.1038/s41598-019-45843-3.
[31]	DING LM, LI XC, LUO WF, et al. Clinical effect of extracorporeal membrane oxygenation in donor liver protection during donation after brain and cardiac death[J]. J Clin Hepatol, 2020, 36(1): 145-148. DOI: 10.3969/j.issn.1001-5256.2020.01.032. 丁利民, 李新长, 罗文峰, 等. 体外膜肺氧合技术对脑心双死亡器官捐献供肝的保护作用[J]. 临床肝胆病杂志, 2020, 36(1): 145-148. DOI: 10.3969/j.issn.1001-5256.2020.01.032.
[32]	ASSALINO M, MAJNO P, TOSO C, et al. In situ liver splitting under extracorporeal membrane oxygenation in brain-dead donor[J]. Am J Transplant, 2018, 18(1): 258-261. DOI: 10.1111/ajt.14461.
[33]	RAMPES S, MA D. Hepatic ischemia-reperfusion injury in liver transplant setting: Mechanisms and protective strategies[J]. J Biomed Res, 2019, 33(4): 221-234. DOI: 10.7555/JBR.32.20180087.
[34]	DEGLI ESPOSTI D, SEBAGH M, PHAM P, et al. Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes[J]. Cell Death Dis, 2011, 2: e111. DOI: 10.1038/cddis.2010.89.

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Research advances in improving the prognosis of recipients of fatty liver transplantation

DOI: 10.3969/j.issn.1001-5256.2021.12.049

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Research advances in improving the prognosis of recipients of fatty liver transplantation

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