Association between immunoglobulin G4-related diseases and autoimmune hepatitis

Lili ZHANG; Aiwen GENG; Chuanwang QI; Jianchun XIAN

doi:10.3969/j.issn.1001-5256.2021.12.050

Volume 37 Issue 12

Dec. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(12): 2972-2975

PDF( 1883 KB)

Association between immunoglobulin G4-related diseases and autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2021.12.050

Department of Hepatopathy, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China

Research funding:

Jiangsu Taizhou Science and Technology Support Plan (Social Development) Project (TS201813)

Received Date: 2021-08-24
Accepted Date: 2021-09-13
Published Date: 2021-12-20

Abstract

Abstract

With the improvement in people's awareness of diseases and the level of diagnosis and treatment, the incidence rates of immunoglobulin G4-related disease (IgG4-RD) and autoimmune liver disease (AILD) are constantly increasing, and IgG4-related sclerosing cholangitis is the overlapping part of the disease spectrum of IgG4-RD and AILD, while the association between IgG4-related autoimmune hepatitis (IgG4-AIH) and these two diseases remains unclear. This article reviews the hepatic manifestation of IgG4-RD, summarizes the clinical features of IgG4-AIH, and analyzes whether IgG4-AIH is a subtype of AIH or a hepatic involvement of IgG4-RD. It is believed that IgG4-AIH has similar but different clinical manifestations and histopathological features from classical AIH, and IgG4-AIH may be classified as two types, i.e., a subtype of AIH and the liver manifestation of IgG4-RD. The research on the pathogenesis, clinical features, and clinical diagnosis and treatment of IgG4-AIH should be taken seriously in future.
- Immunoglobulin G,
- Hepatitis, Autoimmune,
- Autoimmune Diseases

FullText(HTML)

References(34)

References

[1]	UMEMURA T, ZEN Y, HAMANO H, et al. Immunoglobin G4-hepatopathy: Association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis[J]. Hepatology, 2007, 46(2): 463-471. DOI: 10.1002/hep.21700.
[2]	MINAGA K, WATANABE T, CHUNG H, et al. Autoimmune hepatitis and IgG4-related disease[J]. World J Gastroenterol, 2019, 25(19): 2308-2314. DOI: 10.3748/wjg.v25.i19.2308.
[3]	HARADA K, NAKANUMA Y. Pathological differences between IgG4-related sclerosing cholangitis with and without autoimmune pancreatitis[J]. Mod Pathol, 2013, 26(1): 403. DOI: 10.1038/modpathol.2013.17.
[4]	ZENG ZL, LI YL. Research progress in liver injury caused by IgG4- related diseases[J]. Chin J Pract Intern Med, 2021, 41(4): 291-295, 300. DOI: 10.19538/j.nk2021040106. 曾子露, 李异玲. IgG4相关性疾病肝损伤的研究进展[J]. 中国实用内科杂志, 2021, 41(4): 291-295, 300. DOI: 10.19538/j.nk2021040106.
[5]	ZEN Y, FUJⅡ T, SATO Y, et al. Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease[J]. Mod Pathol, 2007, 20(8): 884-894. DOI: 10.1038/modpathol.3800836.
[6]	WANG M, ZHANG S, YANG Q. IgG4-related hepatic inflammatory pseudotumor misdiagnosed as cholangiocellular carcinoma of the liver[J]. J Gastrointest Surg, 2021, 25(4): 1065-1066. DOI: 10.1007/s11605-019-04405-8.
[7]	YUEH HZ, TUNG KK, TUNG CF. IgG4-related pseudotumors mimicking metastases in liver and lungs[J]. Case Rep Gastroenterol, 2021, 15(1): 163-170. DOI: 10.1159/000512410.
[8]	ADACHI Y, IWATA N, ADACHI Y, et al. Coexistence of IgG4-related autoimmune hepatitis and inflammatory pseudotumors of the liver: a case report[J]. Nihon Shokakibyo Gakkai Zasshi, 2020, 117(6): 532-541. DOI: 10.11405/nisshoshi.117.532.
[9]	JANDEE S, BOONSRI P. Atypical manifestations of igg4-related disease as multiple liver abscesses with subcapsular tracts and migratory pulmonary nodules mimicking parasitic infection[J]. Case Rep Gastroenterol, 2020, 14(3): 458-466. DOI: 10.1159/000509501.
[10]	UMEMURA T, ZEN Y, HAMANO H, et al. IgG4 associated autoimmune hepatitis: A differential diagnosis for classical autoimmune hepatitis[J]. Gut, 2007, 56(10): 1471-1472. DOI: 10.1136/gut.2007.122283.
[11]	UMEMURA T, ZEN Y, HAMANO H, et al. Clinical significance of immunoglobulin G4-associated autoimmune hepatitis[J]. J Gastroenterol, 2011, 46(Suppl 1): 48-55. DOI: 10.1007/s00535-010-0323-4.
[12]	CHUNG H, WATANABE T, KUDO M, et al. Identification and characterization of IgG4-associated autoimmune hepatitis[J]. Liver Int, 2010, 30(2): 222-231. DOI: 10.1111/j.1478-3231.2009.02092.x.
[13]	CANIVET CM, ANTY R, PATOURAUX S, et al. Immunoglobulin G4-associated autoimmune hepatitis may be found in Western countries[J]. Dig Liver Dis, 2016, 48(3): 302-308. DOI: 10.1016/j.dld.2015.10.005.
[14]	AYDEMIR Y, AKCOREN Z, DEMIR H, et al. Clinical and histopathological features of immunoglobulin G4-associated autoimmune hepatitis in children[J]. J Gastroenterol Hepatol, 2019, 34(4): 742-746. DOI: 10.1111/jgh.14525.
[15]	ARASE Y, MATSUMOTO K, ANZAI K, et al. Clinicopathological features of autoimmune hepatitis with IgG4-positive plasma cell infiltration[J]. Dig Dis, 2021, 39(3): 225-233. DOI: 10.1159/000510562.
[16]	AMARAPURKAR AD, AMARAPURKAR DN. Immunoglobulin IgG4 and autoimmune hepatitis[J]. Trop Gastroenterol, 2015, 36(2): 112-117. DOI: 10.7869/tg.263.
[17]	ZHANG W, ZENG XF. Focusing on rare rheumatic diseases and standardizing the management of IgG4 related diseases[J]. Chin J Intern Med, 2021, 60(3): 185-186. DOI: 10.3760/cma.j.cn112138-20200803-00727. 张文, 曾小峰. 聚焦风湿罕见病, 规范IgG4相关性疾病的诊治[J]. 中华内科杂志, 2021, 60(3): 185-186. DOI: 10.3760/cma.j.cn112138-20200803-00727.
[18]	DING DS, TU DN, WANG L, et al. Clinical and pathological features of IgG4-related autoimmune hepatitis in children[J]. J Prac Hepatol, 2020, 23(1): 34-37. DOI: 10.3969/j.issn.1672-5069.2020.01.011. 丁冬胜, 涂丹娜, 王丽, 等. 儿童IgG4相关自身免疫性肝炎临床与病理特征分析[J]. 实用肝脏病杂志, 2020, 23(1): 34-37. DOI: 10.3969/j.issn.1672-5069.2020.01.011.
[19]	MOHAPATRA S, CHARILAOU P, SHARMA A, et al. Significance of peripheral eosinophilia for diagnosis of IgG4-related disease in subjects with elevated serum IgG4 levels[J]. Pancreatology, 2020, 20(1): 74-78. DOI: 10.1016/j.pan.2019.11.016.
[20]	KASTIN D, SIEGEL M, ANDERSON R, et al. IgG 4 autoimmune hepatitis presenting as idiopathic hypereosinophilia syndrome[J]. Hepatology, 2021, 73(4): 1615-1617. DOI: 10.1002/hep.31492.
[21]	CHANG A, CHAROENLAP C, AKARAPATIMA K, et al. Immunoglobulin G4-associated autoimmune hepatitis with peripheral blood eosinophilia: A case report[J]. BMC Gastroenterol, 2020, 20(1): 420. DOI: 10.1186/s12876-020-01559-7.
[22]	ARASE Y, MATSUMOTO K, ANZAI K, et al. Clinicopathological features of autoimmune hepatitis with IgG4-positive plasma cell infiltration[J]. Dig Dis, 2021, 39(3): 225-233. DOI: 10.1159/000510562.
[23]	GONG L, SHI JP. Treatment and prognosis of immunoglobulin G4-related hepatobiliary disease[J]. Chin J Hepatol, 2018, 26(6): 411-414. DOI: 10.3760/cma.j.issn.1007-3418.2018.06.004. 龚玲, 施军平. 免疫球蛋白G4相关肝胆疾病的治疗与转归[J]. 中华肝脏病杂志, 2018, 26(6): 411-414. DOI: 10.3760/cma.j.issn.1007-3418.2018.06.004.
[24]	WALLACE ZS, MATTOO H, MAHAJAN VS, et al. Predictors of disease relapse in IgG4-related disease following rituximab[J]. Rheumatology (Oxford), 2016, 55(6): 1000-1008. DOI: 10.1093/rheumatology/kev438.
[25]	WANG R, TANG R, LI B, et al. Gut microbiome, liver immunology, and liver diseases[J]. Cell Mol Immunol, 2021, 18(1): 4-17. DOI: 10.1038/s41423-020-00592-6.
[26]	ZHANG W, DONG LL, ZHU J, et al. Chinese expert consensus on the diagnosis and treatment of IgG4 related diseases[J]. Chin J Intern Med, 2021, 60(3): 192-206. DOI: 10.3760/cma.j.cn112138-20200803-00726. 张文, 董凌莉, 朱剑, 等. IgG4相关性疾病诊治中国专家共识[J]. 中华内科杂志, 2021, 60(3): 192-206. DOI: 10.3760/cma.j.cn112138-20200803-00726.
[27]	JOSHI D, WEBSTER GJ. Biliary and hepatic involvement in IgG4-related disease[J]. Aliment Pharmacol Ther, 2014, 40(11-12): 1251-1261. DOI: 10.1111/apt.12988.
[28]	KANG MK, PARK JG, CHOI JH. Anti-nuclear antibody-negative immunoglobulin G4-associated autoimmune hepatitis mimicking lymphoproliferative disorders[J]. Yeungnam Univ J Med, 2020, 37(2): 136-140. DOI: 10.12701/yujm.2020.00066.
[29]	MA SF, LIN J, ZANG LJ, et al. Clinicopathologic features of IgG4-related disease[J]. Chin J Clin Exp Pathol, 2021, 37(4): 415-419. DOI: 10.13315/j.cnki.cjcep.2021.04.008. 马少飞, 林军, 臧丽娟, 等. IgG4相关性疾病的临床病理特征[J]. 临床与实验病理学杂志, 2021, 37(4): 415-419. DOI: 10.1335/j.cnki.cjcep.2021.04.008.
[30]	NAKANUMA Y, ISHIZU Y, ZEN Y, et al. Histopathology of IgG4-related autoimmune hepatitis and IgG4-related hepatopathy in IgG4-related disease[J]. Semin Liver Dis, 2016, 36(3): 229-241. DOI: 10.1055/s-0036-1584320.
[31]	ZHANG DH, ZHAO J. Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases[J]. J Clin Hepatol, 2019, 35(6): 1401-1405. DOI: 10.3969 /j.issn.1001-5256.2019.06.050. 张德华, 赵婕. IgG4相关性肝胆胰疾病的发病机制[J]. 临床肝胆病杂志, 2019, 35(6): 1401-1405. DOI: 10.3969 /j.issn.1001-5256.2019.06.050.
[32]	SHIOKAWA M, KODAMA Y, SEKIGUCHI K, et al. Laminin 511 is a target antigen in autoimmune pancreatitis[J]. Sci Transl Med, 2018, 10(453): eaaq0997. DOI: 10.1126/scitranslmed.aaq0997.
[33]	HUBERS LM, VOS H, SCHUURMAN AR, et al. Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease[J]. Gut, 2018, 67(4): 728-735. DOI: 10.1136/gutjnl-2017-314548.
[34]	PERUGINO CA, ALSALEM SB, MATTOO H, et al. Identification of galectin-3 as an autoantigen in patients with IgG4-related disease[J]. J Allergy Clin Immunol, 2019, 143(2): 736-745. e6. DOI: 10.1016/j.jaci.2018.05.011.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (757) PDF downloads(71)

Association between immunoglobulin G4-related diseases and autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2021.12.050

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Association between immunoglobulin G4-related diseases and autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2021.12.050

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content