Advances in diagnosis and treatment of IgG4-related hepatobiliary and pancreatic diseases

Tianqi WANG; Yanying LIU

doi:10.3969/j.issn.1001-5256.2022.04.006

Volume 38 Issue 4

Apr. 2022

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Advances in diagnosis and treatment of IgG4-related hepatobiliary and pancreatic diseases

DOI: 10.3969/j.issn.1001-5256.2022.04.006

Tianqi WANG,
Yanying LIU^{,
,}

Department of Rheumatology and Immunology, Beijing Friendship Hospital, Captital Medical University, Beijing 100050, China

Research funding:

Capital's Fund for Healthy Improvement and Researth (2022-2-2026)

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Corresponding author: LIU Yanying, 57495011@qq.com(ORCID: 0000-0003-2609-4052)
Received Date: 2022-01-11
Accepted Date: 2022-02-13
Published Date: 2022-04-20

Abstract

Abstract

IgG4-related hepatobiliary and pancreatic diseases are a part of the IgG4-related disease multiorgan fibroinflammatory disorder, including IgG4-related autoimmune pancreatitis, IgG4-related sclerosing cholangitis, and IgG4-related hepatic involvement. The main pathological features include IgG4⁺ plasma cell/lymphocyte infiltration, storiform fibrosis, obliterative phlebitis, and eosinophil infiltration. The diagnosis of this disease is often based on the comprehensive diagnostic criteria for IgG4-related diseases and organ-specific diagnostic criteria. However, it is difficult to differentiate IgG4-related hepatobiliary and pancreatic diseases from neoplastic diseases, and novel diagnostic biomarkers are expected to improve the sensitivity and specificity of diagnosis. To date, glucocorticoids remain the first-line drug for this disease, and biological agents, especially anti-CD20 monoclonal antibody, may be an alternative therapy for patients with corticosteroid contraindication/intolerance or recurrent/refractory disease.
- IgG4-Related Diseases,
- Pancreatitis,
- Cholangitis, Sclerosing,
- Liver Diseases

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References(46)

References

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Advances in diagnosis and treatment of IgG4-related hepatobiliary and pancreatic diseases

DOI: 10.3969/j.issn.1001-5256.2022.04.006

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