Signaling pathways involved in the active components of Polygonum cuspidatum in treatment of nonalcoholic fatty liver disease and their interaction

Shudi LI; Xinju CHEN; Jiangkai LIU; Zhen WANG; Fei DUAN; Zhuoya YUAN; Lei LIANG; Suling LI

doi:10.3969/j.issn.1001-5256.2022.04.033

Volume 38 Issue 4

Apr. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(4): 902-907

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Signaling pathways involved in the active components of Polygonum cuspidatum in treatment of nonalcoholic fatty liver disease and their interaction

DOI: 10.3969/j.issn.1001-5256.2022.04.033

1.
Henan University of Chinese Medicine, Zhengzhou 450000, China
2.
The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Science and Technology Major Project (2018ZX10303502);

National Natural Science Foundation of China (Joint Fund) (U1504825);

Scientific Research Special Project of Henan Administration of Traditional Chinese Medicine (20-21ZY1011)

More Information

Corresponding author: LI Suling, hk-lsl@163.com(ORCID: 0000-0002-5211-1330)
Received Date: 2021-07-28
Published Date: 2022-04-20

Abstract

Abstract

The pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear, and currently no effective drugs have been approved for the treatment of NAFLD. Polygonum cuspidatum is a natural traditional Chinese medicine with a long history of application, and studies have shown that it plays an important role in the treatment of NAFLD. This article summarizes related research findings in the active components of Polygonum cuspidatum applied in the treatment of NAFLD, and it is found that the active components of Polygonum cuspidatum can improve insulin resistance, exert an anti-oxidative stress effect, regulate lipid metabolism, improve endoplasmic reticulum stress, and alleviate inflammatory infiltration by regulating the signaling pathways including Nrf2, AMPK, NF-κB, SIRT1, and PPARα, thereby exerting a preventive and therapeutic effect on NAFLD, so as to provide a basis and ideas for developing drugs for NAFLD and exploring related mechanisms.
- Non-Alcoholic Fatty Liver Disease,
- Polygonum Cuspidatum,
- Signal Transduction

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References

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Signaling pathways involved in the active components of Polygonum cuspidatum in treatment of nonalcoholic fatty liver disease and their interaction

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Signaling pathways involved in the active components of Polygonum cuspidatum in treatment of nonalcoholic fatty liver disease and their interaction

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