Circulating cell-free DNA-combined liquid biopsy: The key to noninvasive diagnosis of early-stage liver cancer

Tingdan YE; Xuezhong LEI

doi:10.3969/j.issn.1001-5256.2022.04.037

Volume 38 Issue 4

Apr. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(4): 923-926

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Circulating cell-free DNA-combined liquid biopsy: The key to noninvasive diagnosis of early-stage liver cancer

DOI: 10.3969/j.issn.1001-5256.2022.04.037

Tingdan YE¹,
Xuezhong LEI^{2
,
,
,}

1.
West China School of Medicine, Sichuan University, Chengdu 610041, China
2.
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China

Research funding:

National Major Scientific and Technological Special Project during the Thirteenth Five-year Plan Period (2017ZX10202203-008-005)

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Corresponding author: LEI Xuezhong, 18980601317@163.com(ORCID: 0000-0002-2760-8839)
Received Date: 2021-08-12
Published Date: 2022-04-20

Abstract

Abstract

Circulating cell-free DNA (cfDNA) is considered a promising entry point of liquid biopsy for the diagnosis of early-stage liver cancer; however, many studies have confirmed that the diagnostic efficacy of cfDNA alone is not stable, especially that quantitative test alone cannot well reflect the situation of tumor. More and more studies have shown that cfDNA is suitable for combined measurement of multiple indicators or combined measurement with other diagnostic markers for liver cancer. This article reviews the articles on combined liquid biopsy based on cfDNA published up to July 2021, summarizes the existing methods for combined measurement, and briefly describes the birth and research advances in combined diagnostic methods, so as to further clarify the significance and potential of combined liquid biopsy based on cfDNA in the diagnosis of early-stage liver cancer and thus provide ideas for taking better advantages of the diagnostic markers for liver cancer in the future.
- Liver Neoplasms,
- Biopsy,
- Circulating Free DNA,
- Diagnosis

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References(46)

References

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Circulating cell-free DNA-combined liquid biopsy: The key to noninvasive diagnosis of early-stage liver cancer

DOI: 10.3969/j.issn.1001-5256.2022.04.037

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Circulating cell-free DNA-combined liquid biopsy: The key to noninvasive diagnosis of early-stage liver cancer

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