Mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in liver diseases

Yan YANG; Feilin GE; Qian HUANG; Xinyue ZHANG; Rui ZENG; Xiaohe XIAO; Zhaofang BAI; Qin SUN

doi:10.3969/j.issn.1001-5256.2022.04.041

Volume 38 Issue 4

Apr. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(4): 942-946

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Mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in liver diseases

DOI: 10.3969/j.issn.1001-5256.2022.04.041

Yan YANG^1a,
Feilin GE²,
Qian HUANG^1b,
Xinyue ZHANG^1a,
Rui ZENG^1a,
Xiaohe XIAO³,
Zhaofang BAI^{3
,
,
,},
Qin SUN^{1a, 4a, 4b
,
,
,}

1a.
School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
1b.
School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China
2.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
3.
China Military Institute of Chinese Medicine, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
4a.
Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
4b.
National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Research funding:

National Natural Science Foundation of China (8193000309);

Sichuan Provincial Department of Science and Technology Project (2021YFH0150);

Sichuan Administration of Traditional Chinese Medicine Project (2017C012)

More Information

Corresponding author: BAI Zhaofang, baizf2008@hotmail.com(ORCID: 0000-0002-6208-150X); SUN Qin, zxyjhsq@swmu.edu.cn(ORCID: 0000-0002-4624-8808)
Received Date: 2021-08-25
Accepted Date: 2021-09-26
Published Date: 2022-04-20

Abstract

Abstract

Inflammasomes play an important role in the innate immunity of the liver; however, the excessive activation of inflammasomes can lead to liver inflammation and injury. The mechanism of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome-mediated liver injury has been extensively studied. Related studies have shown that the development of various liver diseases may be associated with the excessive activation of inflammasomes, especially NLRP3 inflammasome. This article reviews inflammasomes, the activation mechanism of NLRP3 inflammasome, and the role of NLRP3 inflammasome in different liver diseases, so as to provide a reference for the treatment targets of liver diseases from the perspective of NLRP3 inflammasome.
- NLRP3 Inflammasome,
- Liver Diseases,
- Immunity, Innate

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References(44)

References

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Mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in liver diseases

DOI: 10.3969/j.issn.1001-5256.2022.04.041

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