The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones

Handong ZHAO; Peng GAO; Li ZHAN

doi:10.3969/j.issn.1001-5256.2022.04.042

Volume 38 Issue 4

Apr. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(4): 947-950

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The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones

DOI: 10.3969/j.issn.1001-5256.2022.04.042

Handong ZHAO¹,
Peng GAO^2a,
Li ZHAN^{2b
,
,}

1.
The First Clinical Medical College of Gansu University of Chinese Medicine & Gansu Provincial Hospital, Lanzhou 730000, China
2a.
Department of General Surgery, Gansu Provincial People's Hospital, Lanzhou 730000, China
2b.
Department of Gastroenterology, Gansu Provincial People's Hospital, Lanzhou 730000, China

Research funding:

National Natural Science Foundation of China (81660398)

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Corresponding author: ZHAN Li, zhanlilanzhou@163.com
Received Date: 2021-08-18
Accepted Date: 2021-09-20
Published Date: 2022-04-20

Abstract

Abstract

Gallstone is a common digestive system disease involving multiple factors, more than 80% of which are cholesterol gallstones, and its incidence rate is increasing year by year. Recent studies have shown that intestinal flora is involved in the development and progression of cholesterol gallstones. This article elaborates on the role of intestinal flora and its metabolites in the progression of cholesterol gallstones from the aspect of regulation of bile acids by intestinal flora and its metabolites, and it is pointed out that intervention strategies for intestinal flora and its metabolites may be a new target for the prevention and treatment of cholesterol gallstones in the future.
- Gastrointestinal Microbiome,
- Cholelithiasis,
- Enterohepatic Circulation,
- Bile Acid

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References(37)

References

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The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones

DOI: 10.3969/j.issn.1001-5256.2022.04.042

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The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones

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