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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 6
Jun.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(6): 1383-1386

Role of N6-methyladenosine methylation in hepatitis B virus infection

DOI: 10.3969/j.issn.1001-5256.2022.06.034

  • Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi′an 710038, China

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  • Corresponding author: FAN Chao, fanchao83@163.com(ORCID: 0000-0002-3834-6483)
  • Received Date: 2021-11-09
  • Accepted Date: 2021-12-29
  • Published Date: 2022-06-20
    Abstract
  • The phenomenon of N6-methyladenosine (m6A)-methylation is commonly observed in various tissues and cells of the human body and is the most common type of internal modification in eukaryotic mRNA. m6A-methylation is dynamic and reversible, which is regulated by various methyltransferases, demethylases, and m6A binding protein. Recent studies have shown that m6A modification can affect viral gene expression and plays an important role in the process of HBV infection. This article summarizes the current research status and mechanism of m6A-methylation, especially its association with HBV infection. This article also elaborates on the effect of m6A modification on HBV transcripts, reviews the research findings of m6A in immune response of HBV infection, and summarizes the effect of HBV infection on m6A modification in normal host hepatocytes and hepatitis B liver cancer, so as to discuss the development direction and potential value of m6A in HBV infection.

     

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