Role of platelets in the development and progression of hepatocellular carcinoma

Xiao YU; Guobing WU; Aibin ZHANG; Xiaolong CHENG; Min LIU; Zenan HU; Ya ZHENG; Yuping WANG; Zhaofeng CHEN

doi:10.3969/j.issn.1001-5256.2022.06.043

Volume 38 Issue 6

Jun. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(6): 1426-1430

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Role of platelets in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.06.043

Xiao YU^{1, 2},
Guobing WU^{1, 2},
Aibin ZHANG^{1, 2},
Xiaolong CHENG^{1, 2},
Min LIU²,
Zenan HU²,
Ya ZHENG²,
Yuping WANG²,
Zhaofeng CHEN^{2
,
,
,}

1.
The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
2.
Department of Gastroenterology, The First Hospital of Lanzhou University, Key Laboratory of Gastrointestinal Diseases of Gansu Province, Lanzhou 730000, China

Research funding:

National Natural Science Foundation of China (81960430);

Natural Science Foundation of Gansu Province (21JR1RA073);

The Fund of First Hospital of Lan Zhou University (ldyyyn2018-38)

More Information

Corresponding author: CHEN Zhaofeng, zhfchen@lzu.edu.cn(ORCID: 0000-0003-2921-1111)
Received Date: 2021-10-26
Accepted Date: 2021-11-28
Published Date: 2022-06-20

Abstract

Abstract

Hepatocellular carcinoma is one of the common causes of tumor-related death, and it has high morbidity and mortality rates in China. Recent studies have shown that platelets are closely associated with the development of hepatocellular carcinoma. Literature review shows that platelets not only participate in hemostasis, but also act on liver cells and tumor microenvironment, promote the formation of new blood vessels, and participate in the development and progression of hepatocellular carcinoma as a cell mediator through immune response and other pathways. In addition, platelets and their derivatives can be used as potential therapeutic targets for hepatocellular carcinoma. Therefore, antiplatelet therapy is expected to become a new adjuvant strategy for the treatment of hepatocellular carcinoma, which has important clinical significance.
- Carcinoma, Hepatocellular,
- Blood Platelets,
- Tumor Microenvironment,
- Exosomes,
- Molecular Targeted Therapy

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References(45)

References

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Role of platelets in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.06.043

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Role of platelets in the development and progression of hepatocellular carcinoma

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