Research advances in autoimmune hepatitis-related hepatocellular carcinoma

Wenpei GUO; Haiyan ZHANG; Lixin LIU

doi:10.3969/j.issn.1001-5256.2022.06.044

Volume 38 Issue 6

Jun. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(6): 1431-1435

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Research advances in autoimmune hepatitis-related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.06.044

Wenpei GUO^{1, 2a},
Haiyan ZHANG^{2a, 2b, 2c, 2d},
Lixin LIU^{1, 2a, 2b, 2c, 2d
,
,
,}

1.
The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China
2a.
Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan 030001, China
2b.
Experimental Center of Science and Research, First Hospital of Shanxi Medical University, Taiyuan 030001, China
2c.
Committee-level Key Laboratory of Liver Injury and Gastrointestinal Tumor Prevention and Treatment, First Hospital of Shanxi Medical University, Taiyuan 030001, China
2d.
Institute of Liver Disease and Organ Transplantation, First Hospital of Shanxi Medical University, Taiyuan 030001, China

Research funding:

The Funding of Scientific and Technological Development with Central Government Guiding Local (Department of Science and Technology of Shanxi Province) (YDZX20201400001965)

More Information

Corresponding author: LIU Lixin, lixinliu6@hotmail.com (ORCID: 0000-0001-7585-9432)
Received Date: 2021-10-31
Accepted Date: 2021-12-15
Published Date: 2022-06-20

Abstract

Abstract

Autoimmune hepatitis (AIH)-related hepatocellular carcinoma (HCC) is defined as HCC that develops on the basis of long-term AIH and has a relatively low incidence rate of 0-6%. The risk factors for HCC in AIH patients include old age, male sex, diabetes, alcohol use, AIH recurrence and persistent alanine aminotransferase abnormalities, failure in immunosuppressive therapy and related treatments, and long-term liver cirrhosis. Liver cirrhosis is an important stage for the development of HCC in AIH, and the incidence rate of HCC increases significantly after AIH progresses to liver cirrhosis. At present, there are few reports on the mechanism of HCC in AIH, which may be associated with the changes in specific molecular biological characteristics (including chromosomes, telomeres, and genes) induced by liver cirrhosis, the cell death-inflammation-cancer pathway, and intestinal microecological disorders. It is of great importance to identify the AIH population at a high risk of HCC in a timely manner and enhance intervention, follow-up, and monitoring.
- Hepatitis, Autoimmune,
- Carcinoma, Hepatocellular,
- Liver Cirrhosis,
- Risk Factors

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References(45)

References

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Research advances in autoimmune hepatitis-related hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.06.044

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Research advances in autoimmune hepatitis-related hepatocellular carcinoma

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