Research advances in vitamin D deficiency and metabolic associated fatty liver disease

Ling LUO; Xianhua LIAO; Bihui ZHONG

doi:10.3969/j.issn.1001-5256.2022.07.034

Volume 38 Issue 7

Jul. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(7): 1641-1645

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Research advances in vitamin D deficiency and metabolic associated fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2022.07.034

Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

Research funding:

National Natural Science Foundation of China (81870404);

National Natural Science Foundation of China (81670518);

National Natural Science Foundation of China (81170392);

Guangdong Science and Technology Department (2017A020215015);

Guangdong Science and Technology Department (2014A020212118);

Medical Scientific Research Foundation of Guangdong Province (A2019496);

Chinese Foundation for Hepatitis Prevention and Control (TQGB20140083)

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Corresponding author: ZHONG Bihui, zhongbh@mail.sysu.edu.cn (ORCID: 0000-0002- 4638-7699)
Received Date: 2021-11-16
Accepted Date: 2022-01-14
Published Date: 2022-07-20

Abstract

Abstract

Metabolic associated fatty liver disease (MAFLD) is the largest chronic liver disease in the world. Its pathogenesis remains unclear and there is still a lack of effective drugs. This article introduces vitamin D deficiency commonly observed in patients with MAFLD, and it is pointed out that vitamin D may participate in the development and progression of MAFLD through various pathways such as glucose and lipid metabolism, inflammatory signaling pathways, immune modulation, and intestinal microecology. It is proposed that vitamin D supplement is expected to become an effective drug for the treatment of MAFLD, and the monitoring and management of vitamin D level should be taken seriously for MAFLD patients in clinical practice. Further studies are needed to explore its underlying mechanism, dose for supplementation, and course of treatment.
- Metabolic Associated Fatty Liver Disease,
- Vitamin D,
- Receptors, Calcitriol

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References

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Research advances in vitamin D deficiency and metabolic associated fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2022.07.034

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Research advances in vitamin D deficiency and metabolic associated fatty liver disease

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