中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 7
Jul.  2022
Turn off MathJax
Article Contents

Time distribution of risk factors for secondary pancreatic infection in acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2022.07.044
Research funding:

Key R & D projects of Ningxia Autonomous Region (2020BEG02002);

Key R & D projects of Ningxia Autonomous Region (2021BEG03042);

Ningxia Autonomous Region Science and Technology Benefiting the People Program (2021CMG03013);

Open Project of General Hospital of Ningxia Medical University (Clinical Medical Research Center of Ningxia Autonomous Region) 

More Information
  • Corresponding author: YAO Weijie, ayaoataq@sina.com(ORCID: 0000-0001-7083-6784); WANG Zuozheng, wangzuozheng2008@sina.com (ORCID: 0000-0002-5349-6834)
  • Received Date: 2021-11-17
  • Accepted Date: 2022-01-04
  • Published Date: 2022-07-20
  • Pancreatic infection secondary to acute pancreatitis is an important influencing factor for the death of patients with acute pancreatitis. This article reviews the research on the risk factors for secondary pancreatic infection in acute pancreatitis in recent years and analyzes relevant risk factors according to the time axis of disease development. It is found that the risk factors for secondary pancreatic infection exist throughout the course of disease, and the influencing factors can be categorized into "internal factors" and "external factors". It is the primary task of the "anti-infective" therapy for acute pancreatitis to pay attention to these risk factors and give treatment in time.

     

  • loading
  • [1]
    ZHAO CS, YAO WJ, YANG YF, et al. Clinical study of pancreatic duct stent in the treatment of hypertriglyceridemic pancreatitis[J]. Chin J Hepatobiliary Surg, 2021, 27(8): 589-593. DOI: 10.3760/cma.j.cnl13884-20201015-00544.

    赵成思, 姚维杰, 杨亚飞, 等. 胰管支架治疗高三酰甘油血症性急性胰腺炎的临床研究[J]. 中华肝胆外科杂志, 2021, 27(8): 589-593. DOI: 10.3760/cma.j.cnl13884-20201015-00544.
    [2]
    LYTRAS D, MANES K, TRIANTOPOULOU C, et al. Persistent early organ failure: defining the high-risk group of patients with severe acute pancreatitis?[J]. Pancreas, 2008, 36(3): 249-254. DOI: 10.1097/MPA.0b013e31815acb2c.
    [3]
    Working Party of the British Society of Gastroenterology, Association of Surgeons of Great Britain and Ireland, Pancreatic Society of Great Britain and Ireland, et al. UK guidelines for the management of acute pancreatitis[J]. Gut, 2005, 54(Suppl 3): iii1-iii9. DOI: 10.1136/gut.2004.057026.
    [4]
    WANG Y, ZHANG YJ, YE ML, et al. The distributions and clinical characteristics of pathogenic bacteria in severe acute pancreatitis patients with the secondary infection[J]. J Pract Med, 2017, 33(22): 3773-3776. DOI: 10.3969/j.issn.1006-5725.2017.22.024.

    王瑶, 张友健, 叶美玲, 等. 重症急性胰腺炎继发感染的病原菌分布及临床特点分析[J]. 实用医学杂志, 2017, 33(22): 3773-3776. DOI: 10.3969/j.issn.1006-5725.2017.22.024.
    [5]
    Chinese Society for Emergency Medicine; Beijing-Tianjin-Hebei Alliance of Emergency Treatment and First Aid; Emergency Medicine Branch, Beijing Medical Association, et al. Expert consensus on emergency diagnosis and treatment of acute pancreatitis[J]. J Clin Hepatol, 2021, 37(5): 1034-1041. DOI: 10.3969/j.issn.1001-5256.2021.05.012.

    中华医学会急诊分会, 京津冀急诊急救联盟, 北京医学会急诊分会, 等. 急性胰腺炎急诊诊断及治疗专家共识[J]. 临床肝胆病杂志, 2021, 37(5): 1034-1041. DOI: 10.3969/j.issn.1001-5256.2021.05.012.
    [6]
    Pancreas Study Group, Chinese Society of Gastroenterology, Chinese Medical Association, Editorial Board of Chinese Journal of Pancreatology, Editorial Board of Chinese Journal of Digestion. Chinese guidelines for the management of acute pancreatitis (Shenyang, 2019)[J]. J Clin Hepatol, 2019, 35(12): 2706-2711. DOI: 10.3969/j.issn.1001-5256.2019.12.013.

    中华医学会消化病学分会胰腺疾病学组, 《中华胰腺病杂志》编委会, 《中华消化杂志》编委会. 中国急性胰腺炎诊治指南(2019年, 沈阳)[J]. 临床肝胆病杂志, 2019, 35(12): 2706-2711. DOI: 10.3969/j.issn.1001-5256.2019.12.013.
    [7]
    MAO EQ, LI ZS. Re-recognition of the etiological diagnosis and classification for acute pancreatitis[J]. Chin J Pancreato, 2019, 19(6): 401-402. DOI: 10.3760/cma.j.issn.1674-1935.2019.06.001.

    毛恩强, 李兆申. 急性胰腺炎病因诊断与分类的再认识[J]. 中华胰腺病杂志, 2019, 19(6): 401-402. DOI: 10.3760/cma.j.issn.1674-1935.2019.06.001.
    [8]
    ZHAO CS, YAO WJ, WANG ZZ. Advances in the treatment of hypertriglyceridemic pancreatitis[J]. J Clin Hepatol, 2020, 36(12): 2860-2864. DOI: 10.3969/j.issn.1001-5256.2020.12.047.

    赵成思, 姚维杰, 王佐正. 高三酰甘油血症性急性胰腺炎治疗进展[J]. 临床肝胆病杂志, 2020, 36(12): 2860-2864. DOI: 10.3969/j.issn.1001-5256.2020.12.047.
    [9]
    ZOU JY, LIN J, YI SF, et al. Comparison of BISAP, Ranson's, APACHE Ⅱ and CTSI scores in evaluating the severity of acute pancreatitis[J]. Chin J Dig Surg, 2014, 13(1): 39-43. DOI: 10.3760/cma.j.issn.1673-9752.2014.01.012.

    邹金艳, 林军, 易三风, 等. BISAP、Ranson's、APACHEⅡ和CTSI评分系统在急性胰腺炎评估中的价值[J]. 中华消化外科杂志, 2014, 13(1): 39-43. DOI: 10.3760/cma.j.issn.1673-9752.2014.01.012.
    [10]
    XIE H, ZHANG YW, WU DY. Clinical characteristics of severe acute pancreatitis patients with secondary pancreatic infection and influencing factors[J]. Chin J Nosocomiol, 2019, 29(5): 730-733. DOI: 10.11816/cn.ni.2019-180611.

    谢红, 张雅卫, 吴丹阳. 重症急性胰腺炎继发胰腺感染的临床特点和影响因素分析[J]. 中华医院感染学杂志, 2019, 29(5): 730-733. DOI: 10.11816/cn.ni.2019-180611.
    [11]
    BALTHAZAR EJ. Acute pancreatitis: assessment of severity with clinical and CT evaluation[J]. Radiology, 2002, 223(3): 603-613. DOI: 10.1148/radiol.2233010680.
    [12]
    PING Z, ZHANG JJ, CHEN HJ, et al. Meta-analysis of risk factors for secondary pancreatic infection of patients with severe acute pancreatitis in China[J]. Chin J Hosp Pharm, 2021, 41(14): 1454-1460. DOI: 10.13286/j.1001-5213.2021.14.14.

    平泽, 张建军, 陈赫军, 等. 系统评价我国重症急性胰腺炎患者继发胰腺感染的危险因素[J]. 中国医院药学杂志, 2021, 41(14): 1454-1460. DOI: 10.13286/j.1001-5213.2021.14.14.
    [13]
    ZENG YB, ZHAN XB, GUO XR, et al. Risk factors for pancreatic infection in patients with severe acute pancreatitis: an analysis of 163 cases[J]. J Dig Dis, 2014, 15(7): 377-385. DOI: 10.1111/1751-2980.12150.
    [14]
    YANG X, LIU RH, XIE C, et al. Protective effect of early abdominal paracentesis drainage against kidney injury secondary to severe acute pancreatitis[J]. Chin J Gen Surg, 2021, 30(3): 321-329. DOI: 10.7659/j.issn.1005-6947.2021.03.010.

    杨熊, 刘若鸿, 谢川, 等. 早期腹腔穿刺引流对重症急性胰腺炎肾损伤的保护作用[J]. 中国普通外科杂志, 2021, 30(3): 321-329. DOI: 10.7659/j.issn.1005-6947.2021.03.010.
    [15]
    RUAN Q, LU H, ZHU H, et al. A network-regulative pattern in the pathogenesis of kidney injury following severe acute pancreatitis[J]. Biomed Pharmacother, 2020, 125: 109978. DOI: 10.1016/j.biopha.2020.109978.
    [16]
    QIAO SF, SUN JB, LI F. Relative factors and preventive measures of pancreatic infection in severe acute pancreatitis[J]. Clin Med China, 2006, 22(3): 252-253. DOI: 10.3760/cma.j.issn.1008-6315.2006.03.025.

    乔世峰, 孙家邦, 李非. 重症急性胰腺炎患者胰腺感染的相关因素分析及防治措施[J]. 中国综合临床, 2006, 22(3): 252-253. DOI: 10.3760/cma.j.issn.1008-6315.2006.03.025.
    [17]
    XUE P, HUANG ZW, LI YH, et al. Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage[J]. J Integr Med, 2005, 3(6): 28-30. DOI: 1672-1977(2005)06-0443-03.

    薛平, 黄宗文, 李永红, 等. 重症急性胰腺炎早期低白蛋白血症的临床研究[J]. 中西医结合学报, 2005, 3(6): 28-30. DOI: 1672-1977(2005)06-0443-03.
    [18]
    ZOU C, LU Z, ZHANG Z, et al. Factors associated with pancreatic infection in patients with severe acute pancreatisis[J]. Int J Clin Exp Med, 2015, 8(8): 14100-14104.
    [19]
    BILOTTA AJ, CONG Y. Gut microbiota metabolite regulation of host defenses at mucosal surfaces: implication in precision medicine[J]. Precis Clin Med, 2019, 2(2): 110-119. DOI: 10.1093/pcmedi/pbz008.
    [20]
    YACHIMSKI PS, ROSS A. The future of endoscopic retrograde cholangiopancreatography[J]. Gastroenterology, 2017, 153(2): 338-344. DOI: 10.1053/j.gastro.2017.06.015.
    [21]
    ZHANG GJ, ZHANG DY, CAI FC, et al. New development of endoscopic retrograde cholangiopancreatography in the diagnosis and treatment[J/CD]. Chin J Gastrointest Endosc (Electronic Edition), 2020, 7(4): 205-210. DOI: 10.3877/cma.j.issn.2095-7157.2020.04.008.

    张贯军, 张大涯, 蔡逢春, 等. 内镜逆行胰胆管造影术诊治新进展[J/CD]. 中华胃肠内镜电子杂志, 2020, 7(4): 205-210. DOI: 10.3877/cma.j.issn.2095-7157.2020.04.008.
    [22]
    WANG SH, WU LY, JIA GF, et al. Influencing factors of cholangitis after ERCP in elderly patients with malignant biliary obstruction[J]. Chin J Gerontol, 2021, 41(14): 3120-3123. DOI: 10.3969/j.issn.1005-9202.2021.14.056.

    王书海, 吴丽颖, 贾国法, 等. 老年恶性胆道梗阻患者ERCP术后发生胆管炎的影响因素[J]. 中国老年学杂志, 2021, 41(14): 3120-3123. DOI: 10.3969/j.issn.1005-9202.2021.14.056.
    [23]
    YIN ZY, LIU Q, LI XM, et al. Endoscopic retrograde cholangio-pancreatography for pancreatic duct stones[J/CD]. Chin J Hepat Surg(Electronic Edition), 2020, 9(5): 466-470. DOI: 10.3877/cma.j.issn.2095-3232.2020.05.016.

    尹振宇, 刘乾, 李晓梅, 等. ERCP治疗胰管结石[J/CD]. 中华肝脏外科手术学电子杂志, 2020, 9(5): 466-470. DOI: 10.3877/cma.j.issn.2095-3232.2020.05.016.
    [24]
    FOGEL EL, SHERMAN S. ERCP for gallstone pancreatitis[J]. N Engl J Med, 2014, 370(2): 150-157. DOI: 10.1056/NEJMct1208450.
    [25]
    LIANG H, AI XB, PAN WS. Relationship between hypoalbuminemia, pleural effusion and risk factors of death in severe acute pancreatitis[J]. Chin J Emerg Med, 2012, 21(8): 902-904. DOI: 10.3760/cma.j.issn.1671-0282.2012.08.025.

    梁晖, 艾新波, 潘文胜. 低白蛋白血症, 胸腔积液与重症急性胰腺炎死亡危险因素的相关性[J]. 中华急诊医学杂志, 2012, 21(8): 902-904. DOI: 10.3760/cma.j.issn.1671-0282.2012.08.025.
    [26]
    FENG DX, HAN F, ZHU SJ, et al. Study on the relationship between continuous hyperglycemia and progression of early acute pancreatitis[J]. Chin J Gen Surg, 2004, 19(11): 16-18. DOI: 10.3760/j.issn:1007-631X.2004.11.006.

    奉典旭, 韩峰, 朱士驹, 等. 持续高血糖与急性胰腺炎早期病情发展的关系[J]. 中华普通外科杂志, 2004, 19(11): 16-18. DOI: 10.3760/j.issn:1007-631X.2004.11.006.
    [27]
    DUAN PY, SUN B, WANG G, et al. The role of diabetes in the development of acute pancreatitis[J]. Chin J Pancreatol, 2018, 18(1): 59-61. DOI: 10.3760/cma.j.issn.1674-1935.2018.01.019.

    段鹏羽, 孙备, 王刚, 等. 糖尿病在急性胰腺炎发生发展中的作用[J]. 中华胰腺病杂志, 2018, 18(1): 59-61. DOI: 10.3760/cma.j.issn.1674-1935.2018.01.019.
    [28]
    van den BERGHE G, WOUTERS P, WEEKERS F, et al. Intensive insulin therapy in critically ill patients[J]. N Engl J Med, 2001, 345(19): 1359-1367. DOI: 10.1056/NEJMoa011300.
    [29]
    LI YJ, GAO F, LIU HF. Curative effect of Salvia miltiorrhiza ligustrazine on the protection of intestinal barrier in severe acute pancreatitis[J]. J Chin Physician, 2016, Z1: 33-34. DOI: 10.3760/cma.j.issn.1008-1372.2016.z1.010.

    李燕军, 高飞, 刘海峰. 丹参川芎嗪对重症急性胰腺炎肠屏障保护作用的疗效观察[J]. 中国医师杂志, 2016, Z1: 33-34. DOI: 10.3760/cma.j.issn.1008-1372.2016.z1.010.
    [30]
    TANG YH, KONG J, ZHOU BD, et al. The role of intestinal microbiota in the progression of severe acute pancreatitis and its potential therapeutic implications[J]. Chin J Microecol, 2021, 33(8): 980-984. DOI: 10.13381/j.cnki.cjm.202108024.

    唐义爽, 孔婧, 周秉舵, 等. 肠道微生物在重症急性胰腺炎进展中的作用及其潜在的治疗意义[J]. 中国微生态学杂志, 2021, 33(8): 980-984. DOI: 10.13381/j.cnki.cjm.202108024.
    [31]
    MI YY, HUANG HY, SHANG Y, et al. Expert consensus on prevention and management of enteral nutrition therapy complications for critically ill patients in China (2021 edition)[J]. Chin Crit Care Med, 2021, 33(8): 903-918. DOI: 10.3760/cma.j.cn121430-20210310-00357.

    米元元, 黄海燕, 尚游, 等. 中国危重症患者肠内营养治疗常见并发症预防管理专家共识(2021版)[J]. 中华危重病急救医学, 2021, 33(8): 903-918. DOI: 10.3760/cma.j.cn121430-20210310-00357.
    [32]
    WANG SG, SHI RL, WANG WJ. Impact of intestinal function on pancreatic infection in patients with severe acute pancreatitis[J]. Chin J Nosocomiol, 2019, 29(14): 2158-2161. DOI: 10.11816/cn.ni.2019-181777.

    王思广, 史瑞林, 王文杰. 肠功能水平对重症急性胰腺炎患者胰腺感染影响的研究[J]. 中华医院感染学杂志, 2019, 29(14): 2158-2161. DOI: 10.11816/cn.ni.2019-181777.
    [33]
    NSEIR S, ZERIMECH F, JAILLETTE E, et al. Microaspiration in intubated critically ill patients: diagnosis and prevention[J]. Infect Disord Drug Targets, 2011, 11(4): 413-423. DOI: 10.2174/187152611796504827.
    [34]
    MENG X, WANG W, ZHANG YL, et al. Progress in diagnosis and treatment of ventilator-associated pneumonia[J]. Chin J Med, 2021, 56(9): 932-935. DOI: 10.3969/j.issn.1008-1070.2021.09.002.

    孟晓, 王伟, 张延玲, 等. 呼吸机相关性肺炎的诊疗进展[J]. 中国医刊, 2021, 56(9): 932-935. DOI: 10.3969/j.issn.1008-1070.2021.09.002.
    [35]
    QI HM, ZHU TM, WANG J. Risk factors of secondary pancreatic infection in patients with severe acute pancreatitis[J]. Chin Gen Practice, 2009, 12(23): 2165-2166. DOI: 10.3969/j.issn.1007-9572.2009.23.024.

    戚灴明, 朱铁明, 王坚. 重症急性胰腺炎继发胰腺感染预后影响因素分析[J]. 中国全科医学, 2009, 12(23): 2165-2166. DOI: 10.3969/j.issn.1007-9572.2009.23.024.
    [36]
    DUAN XQ, XU P, SONG CF. Features of infection of central venous catheter in severe acute pancreatitis[J]. Chin J Hepatobiliary Surg, 2004, 10(8): 32-34. DOI: 10.3760/cma.j.issn.1007-8118.2004.08.010.

    段秀庆, 许评, 宋春芳. 重症急性胰腺炎病人中心静脉导管感染的特点[J]. 中华肝胆外科杂志, 2004, 10(8): 32-34. DOI: 10.3760/cma.j.issn.1007-8118.2004.08.010.
    [37]
    ZHOU SY, HUANG GW, SHEN DC, et al. Analysis of risk factors for peripancreatic infection secondary to acute pancreatitis[J]. Chin J Gen Surg, 2018, 27(9): 1148-1154. DOI: 10.7659/j.issn.1005-6947.2018.09.010.

    周书毅, 黄耿文, 申鼎成, 等. 急性胰腺炎继发胰周感染的危险因素分析[J]. 中国普通外科杂志, 2018, 27(9): 1148-1154. DOI: 10.7659/j.issn.1005-6947.2018.09.010.
    [38]
    GLIEM N, AMMER-HERRMENAU C, ELLENRIEDER V, et al. Management of severe acute pancreatitis: an update[J]. Digestion, 2021, 102(4): 503-507. DOI: 10.1159/000506830.
    [39]
    WANG Q, DU T, DING X. A systematic review of early oral refeeding versus conventional oral refeeding for acute pancreatitis[J]. J Chongqing Med Univ, 2016, 41(3): 292-297. DOI: 10.13406/j.cnki.cyxb.000810.

    王强, 杜涛, 丁雄. 早期进食与标准时机进食治疗急性胰腺炎效果的系统评价[J]. 重庆医科大学学报, 2016, 41(3): 292-297. DOI: 10.13406/j.cnki.cyxb.000810.
    [40]
    PENG YL, GAO Q. Analysis of clinical characteristics and risk factors of 120 patients of severe acute pancreatitis with secondary fungal infection[J]. Chin J Dig, 2021, 41(7): 466-470. DOI: 10.3760/cma.j.cn311367-20201105-00644.

    彭越岭, 高青. 重症急性胰腺炎继发真菌感染120例患者的临床特点和危险因素分析[J]. 中华消化杂志, 2021, 41(7): 466-470. DOI: 10.3760/cma.j.cn311367-20201105-00644.
    [41]
    Pancreatic Surgery Group, Branch of Surgery, Chinese Medical Association. Guidelines for diagnosis and treatment of acute pancreatitis in China (2021)[J]. Chin J Dig Surg, 2021, 20(7): 730-739. DOI: 10.3760/cma.j.cn115610-20210622-00297.

    中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021)[J]. 中华消化外科杂志, 2021, 20(7): 730-739. DOI: 10.3760/cma.j.cn115610-20210622-00297.
    [42]
    ZENG YB, DU YQ. Current status quo of diagnosis and treatment of acute pancreatitis from the perspective of Chinese guidelines for the management of acute pancreatitis 2019 edition[J]. Chin J Pancreatol, 2020, 20(6): 405-408. DOI: 10.3760/cma.j.cn115667-20201014-00171.

    曾彦博, 杜奕奇. 从2019版中国急性胰腺炎诊治指南看急性胰腺炎诊疗现状[J]. 中华胰腺病杂志, 2020, 20(6): 405-408. DOI: 10.3760/cma.j.cn115667-20201014-00171.
    [43]
    BARON TH, DIMAIO CJ, WANG AY, et al. American Gastroenterological Association Clinical Practice Update: Management of pancreatic necrosis[J]. Gastroenterology, 2020, 158(1): 67-75. e1. DOI: 10.1053/j.gastro.2019.07.064.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (690) PDF downloads(60) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return