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Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2836-2840

Protective mechanism of interleukin-10 against nonalcoholic fatty liver disease and its prospect in treatment

DOI: 10.3969/j.issn.1001-5256.2022.12.029

  • Department of Gastroenterology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China

Research funding:

Shaanxi Social Development Science and Technology Project (2016SF-120);

Shaanxi Provincial Department of Education Sepcial Scientific Research Project (19JK0969)

More Information
  • Corresponding author: DAI Guangrong, 303326374@qq.com (ORCID: 0000-0002-7126-2257)
  • Received Date: 2022-04-03
  • Accepted Date: 2022-05-06
  • Published Date: 2022-12-20
    Abstract
  • With the prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the largest chronic liver disease in China. However, the pathogenesis of NAFLD remains unclear, and recent studies have found that interleukin-10 (IL-10) not only plays an important role in the pathogenesis of autoimmune diseases, inflammatory diseases, and malignant tumors, but also plays a key regulatory role in the pathogenesis of NAFLD. This article reviews the protective mechanism of IL-10 against NAFLD and its prospect in treatment, so as to further explore the clinical value of IL-10 in the diagnosis and treatment of NAFLD.

     

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