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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2855-2858

Advances in application of transarterial chemoembolization combined with targeted therapy/immunotherapy in advanced hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.12.033

  • Department of Minimally Invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University & Cancer Hospital of Henan Province, Zhengzhou 450008, China

Research funding:

Henan Provincial Natural Science Foundation General Project (212300410403);

2022 Henan Provincial Department of Human Resources and Social Security Research Scholarship for Overseas Students ;

2022 Henan Provincial Department of Human Resources and Social Security Research Scholarship for Overseas Students; Henan Provincial Medical Education Research Project (Wjlx2021334)

More Information
  • Corresponding author: HU Hongtao, huhongtaogy@163.com (ORCID: 0000-0002-5432-4014)
  • Received Date: 2022-04-11
  • Accepted Date: 2022-06-15
  • Published Date: 2022-12-20
    Abstract
  • Most of the patients with hepatocellular carcinoma (HCC) in China are in the advanced stage at the time of diagnosis, and the treatment methods for HCC mainly include transarterial chemoembolization and systemic therapy. This article introduces the targeted drugs represented by sorafenib and lenvatinib, and the emergence of immunotherapy. Atezolizumab combined with bevacizumab has been approved as the first-line therapy for HCC, and meanwhile, studies on TACE combined with targeted therapy and/or immunotherapy have achieved a satisfactory treatment outcome, which brings better survival and prognosis for patients with advanced HCC. However, more studies are needed to solve the issues related to the prognosis of advanced HCC.

     

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