Application of proton pump inhibitors in acute-on-chronic liver failure

Yuhao YAO; Xiao XIA; Jiaxin ZHANG; Xiaoke LI; Yong'an YE

doi:10.3969/j.issn.1001-5256.2022.12.035

Volume 38 Issue 12

Dec. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(12): 2864-2867

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Application of proton pump inhibitors in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2022.12.035

Yuhao YAO^{1, 2},
Xiao XIA³,
Jiaxin ZHANG^{2, 4},
Xiaoke LI^{2, 4
,
,
,},
Yong'an YE^{2, 4
,
,
,}

1.
The First Clinical Medical School, Beijing University of Chinese Medicine, Beijing 100029, China
2.
Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3.
Department of Pneumology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
4.
Liver Diseases Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100700, China

Research funding:

National Natural Science Foundation of China (82174341);

Scientific Research Projects of National Administration of Traditional Chinese Medicine (JDZX2015300);

Major Research Project of Beijing University of Chinese Medicine (2022-JYB-ZDGG-115)

More Information

Corresponding author: LI Xiaoke, lixiaoke@vip.163.com (ORCID: 0000-0002-1775-3063); YE Yong'an, yeyongan@vip.163.com (ORCID: 0000-0001-9765-4665)
Received Date: 2022-04-20
Accepted Date: 2022-05-24
Published Date: 2022-12-20

Abstract

Abstract

Proton pump inhibitors (PPIs) are commonly used in clinical practice and are currently widely used in people with acute-on-chronic liver failure (ACLF). However, such medication is still not supported by the recommendations in the latest version of Clinical guidelines for acute-on-chronic liver failure issued by American College of Gastroenterology. With reference to the guidelines or consensus statements in China and globally and the latest research advances, this article elaborates on the indications, possible benefits, and potential risks of PPIs used in people with ACLF, in order to provide a reference for the standardized use of PPIs in the population with ACLF in clinical practice.
- Liver Failure,
- Proton Pump Inhibitors,
- Therapeutic Uses

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References(36)

References

[1]	National Health Commission of the People's Republic of China. Guidelines for the clinical use of proton pump inhibitors (2020 Edition)[J]. Chin Pract J Rural Doctor, 2021, 28(1): 1-9. DOI: 10.3969/j.issn.1672-7185.2021.01.001. 中华人民共和国国家卫生健康委员会. 质子泵抑制剂临床应用指导原则(2020年版)[J]. 中国实用乡村医生杂志, 2021, 28(1): 1-9. DOI: 10.3969/j.issn.1672-7185.2021.01.001.
[2]	ZHANG M, XU X, LIU W, et al. Proton pump inhibitor therapy increases the risk of spontaneous bacterial peritonitis in patients with HBV-related acute-on-chronic liver failure[J]. Adv Ther, 2021, 38(9): 4675-4694. DOI: 10.1007/s12325-021-01844-1.
[3]	BIAN M, CHEN SM, SHI WZ, et al. Analysis and investigation in the current situation of using proton pump inhibitor in intensive care unit in six cities in China from 2014 to 2020[J]. Clin Med J, 2022, 20(2): 32-38. DOI: 10.3969/j.issn.1672-3384.2022.02.007. 边萌, 陈淑敏, 史卫忠, 等. 2014—2020年我国六城市重症医学科质子泵抑制剂用药现状调查与分析[J]. 临床药物治疗杂志, 2022, 20(2): 32-38. DOI: 10.3969/j.issn.1672-3384.2022.02.007.
[4]	SUN S, YE W, ZHAO R, et al. Proton pump inhibitor therapy does not affect prognosis of cirrhosis patients with acute decompensation and acute-on-chronic liver failure: A Single-center prospective study[J]. Front Med (Lausanne), 2021, 8: 763370. DOI: 10.3389/fmed.2021.763370.
[5]	LIN ZN, ZUO YQ, HU P. Association of proton pump inhibitor therapy with hepatic encephalopathy in hepatitis B virus-related acute-on-chronic liver failure[J]. Hepat Mon, 2014, 14(4): e16258. DOI: 10.5812/hepatmon.16258.
[6]	BAJAJ JS, O'LEARY JG, LAI JC, et al. Acute-on-chronic liver failure clinical guidelines[J]. Am J Gastroenterol, 2022, 117(2): 225-252. DOI: 10.14309/ajg.0000000000001595.
[7]	SARIN SK, CHOUDHURY A, SHARMA MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update[J]. Hepatol Int, 2019, 13(4): 353-390. DOI: 10.1007/s12072-019-09946-3.
[8]	MEZZANO G, JUANOLA A, CARDENAS A, et al. Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis[J]. Gut, 2022, 71(1): 148-155. DOI: 10.1136/gutjnl-2020-322161.
[9]	AL-MAHTAB M, AKBAR SM, GARG H. Influence of variceal bleeding on natural history of ACLF and management options[J]. Hepatol Int, 2016, 10(3): 436-439. DOI: 10.1007/s12072-015-9677-2.
[10]	ZHAO H, ZHAO R, HU J, et al. Upper gastrointestinal hemorrhage in acute-on-chronic liver failure: prevalence, characteristics, and impact on prognosis[J]. Expert Rev Gastroenterol Hepatol, 2019, 13(3): 263-269. DOI: 10.1080/17474124.2019.1567329.
[11]	Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2018)[J]. J Clin Hepatol, 2019, 35(1): 38-44. DOI: 10.3969/j.issn.1001-5256.2019.01.007. 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 临床肝胆病杂志, 2019, 35(1): 38-44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.
[12]	European Association for the Study of the Liver, Clinical practice guidelines panel, WENDON J, et al. EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure[J]. J Hepatol, 2017, 66(5): 1047-1081. DOI: 10.1016/j.jhep.2016.12.003.
[13]	任红主译. SCHIFF肝脏病学[M]. 北京: 中国科学技术出版社, 2021. REN H. Schiff's Diseases of the liver, 12e[M]. Beijing: China Science And Technology Press, 2021.
[14]	Beijing Society of Portal Hypertension, Portal Hypertension Expert Committee, Liver Disease Committee of Chinese Research Hospital Association. Expert consensus on multidisciplinary diagnosis and treatment of cirrhotic portal hypertension (based on hepatic venous pressure gradient)[J]. J Clin Hepatol, 2021, 37(9): 2037-2044. DOI: 10.3969/j.issn.1001-5256.2021.09.008. 北京医师协会门静脉高压专科医师分会, 中国研究型医院学会肝病专业委员会门静脉高压学组, 中国研究型医院学会肝病专业委员会. 肝硬化门静脉高压症多学科诊治(基于肝静脉压力梯度)专家共识[J]. 临床肝胆病杂志, 2021, 37(9): 2037-2044. DOI: 10.3969/j.issn.1001-5256.2021.09.008.
[15]	Chinese Society of Hepatology, Chinese Society of Gastroenterology, Chinese Society of Endoscopy. Guidelines for the diagnosis and treatment of esophageal and gastric variceal bleeding in cirrhotic portal hypertension[J]. J Clin Hepatol, 2016, 32(2): 203-219. DOI: 10.3969/j.issn.1001-5256.2016.02.002. 中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会内镜学分会. 肝硬化门静脉高压食管胃静脉曲张出血的防治指南[J]. 临床肝胆病杂志, 2016, 32(2): 203-219. DOI: 10.3969/j.issn.1001-5256.2016.02.002.
[16]	DE FRANCHIS R, BOSCH J, GARCIA-TSAO G, et al. Baveno Ⅶ-Renewing consensus in portal hypertension[J]. J Hepatol, 2022, 76(4): 959-974. DOI: 10.1016/j.jhep.2021.12.022.
[17]	PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, et al. Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among icu patients receiving invasive mechanical ventilation: The PEPTIC randomized clinical trial[J]. JAMA, 2020, 323(7): 616-626. DOI: 10.1001/jama.2019.22190.
[18]	ALSHAMSI F, BELLEY-COTE E, COOK D, et al. Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials[J]. Crit Care, 2016, 20(1): 120. DOI: 10.1186/s13054-016-1305-6.
[19]	SREEDHARAN A, MARTIN J, LEONTIADIS GI, et al. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding[J]. Cochrane Database Syst Rev, 2010, (7): CD005415. DOI: 10.1002/14651858.CD005415.pub3.
[20]	CHEN CL, MAO H, TANG YL, et al. Effective assessment of PPI in cirrhotic patients[J]. Chin J Gastroenterol Hepatol, 2012, 21(3): 250-252. DOI: 10.3969/j.issn.1006-5709.2012.03.016. 陈春林, 毛华, 唐银丽, 等. 质子泵抑制剂用于肝硬化患者的疗效评估[J]. 胃肠病学和肝病学杂志, 2012, 21(3): 250-252. DOI: 10.3969/j.issn.1006-5709.2012.03.016.
[21]	NAKATAKE R, HISHIKAWA H, KOTSUKA M, et al. The proton pump inhibitor lansoprazole has hepatoprotective effects in in vitro and in vivo rat models of acute liver injury[J]. Dig Dis Sci, 2019, 64(10): 2854-2866. DOI: 10.1007/s10620-019-05622-6.
[22]	NISHI T, YAMAMOTO Y, YAMAGISHI N, et al. Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats[J]. J Pharm Pharmacol, 2018, 70(3): 383-392. DOI: 10.1111/jphp.12870.
[23]	ELTAHIR HM, NAZMY MH. Esomeprazole ameliorates CCl₄ induced liver fibrosis in rats via modulating oxidative stress, inflammatory, fibrogenic and apoptotic markers[J]. Biomed Pharmacother, 2018, 97: 1356-1365. DOI: 10.1016/j.biopha.2017.11.028.
[24]	AL-HADRAWY S, MAHDI AL-TURFI ZS. Effects of the long-term treatment of proton pump inhibitors on the function of kidney and liver in laboratory female rats[J]. Arch Razi Inst, 2021, 76(4): 975-983. DOI: 10.22092/ari.2021.355947.1745.
[25]	ATKINS C, MAHESWARAN T, RUSHBROOK S, et al. Lansoprazole-induced acute lung and liver injury: a case report[J]. Int J Clin Pharmacol Ther, 2014, 52(12): 1102-1104. DOI: 10.5414/CP202110.
[26]	GARCÍA-CORTÉS M, LUCENA MI, ANDRADE RJ, et al. Lansoprazole-induced hepatic dysfunction[J]. Ann Pharmacother, 2003, 37(11): 1731. DOI: 10.1345/aph.1C268.
[27]	THOMAS B, MOHAMED M, AL HAIL M, et al. A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis[J]. Clin Pharmacol, 2016, 8: 199-202. DOI: 10.2147/CPAA.S106234.
[28]	ROGALSKI P, ZABOROWSKA M, MAZUR M, et al. Gastrointestinal hemorrhage as an acute-on-chronic liver failure trigger in cirrhotic patients[J]. Adv Clin Exp Med, 2022. DOI: 10.17219/acem/147464.
[29]	LO EA, WILBY KJ, ENSOM MH. Use of proton pump inhibitors in the management of gastroesophageal varices: a systematic review[J]. Ann Pharmacother, 2015, 49(2): 207-219. DOI: 10.1177/1060028014559244.
[30]	GARCIA-SAENZ-DE-SICILIA M, SANCHEZ-AVILA F, CHAVEZ-TAPIA NC, et al. PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis[J]. World J Gastroenterol, 2010, 16(46): 5869-5873. DOI: 10.3748/wjg.v16.i46.5869.
[31]	BAJAJ JS, ZADVORNOVA Y, HEUMAN DM, et al. Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites[J]. Am J Gastroenterol, 2009, 104(5): 1130-1134. DOI: 10.1038/ajg.2009.80.
[32]	JANKA T, TORNAI T, BORBÉLY B, et al. Deleterious effect of proton pump inhibitors on the disease course of cirrhosis[J]. Eur J Gastroenterol Hepatol, 2020, 32(2): 257-264. DOI: 10.1097/MEG.0000000000001499.
[33]	KWON JH, KOH SJ, KIM W, et al. Mortality associated with proton pump inhibitors in cirrhotic patients with spontaneous bacterial peritonitis[J]. J Gastroenterol Hepatol, 2014, 29(4): 775-781. DOI: 10.1111/jgh.12426.
[34]	SHALIMAR, ROUT G, JADAUN SS, et al. Prevalence, predictors and impact of bacterial infection in acute on chronic liver failure patients[J]. Dig Liver Dis, 2018, 50(11): 1225-1231. DOI: 10.1016/j.dld.2018.05.013.
[35]	LIN ZN, ZUO YQ, ZHOU Z, et al. Association of proton pump inhibitor therapy with hepatic encephalopathy in acute-on-chronic liver failure[C]//Proceedings of the 16th National Conference on hepatitis and liver diseases of the Chinese Medical Association. 2013: 413-414. 蔺朝妮, 左永清, 周智, 等. 慢加急性肝衰竭患者质子泵抑制剂的应用与肝性脑病的关系[C]//中华医学会第十六次全国病毒性肝炎及肝病学术会议论文集. 2013: 413-414.
[36]	de ROZA MA, KAI L, KAM JW, et al. Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis[J]. World J Gastroenterol, 2019, 25(33): 4933-4944. DOI: 10.3748/wjg.v25.i33.4933.

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Application of proton pump inhibitors in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2022.12.035

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