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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2877-2881

Research advances in the value of related markers in predicting the severity and prognosis of acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2022.12.038

  • Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China

Research funding:

Hospital Clinical Research Project of The Second Affiliated Hospital of Kunming Medical University (2020ynlc013)

More Information
  • Corresponding author: YANG Jing, yangjing_dl@163.com (ORCID: 0000-0003-3305-8893)
  • Received Date: 2022-05-17
  • Accepted Date: 2022-06-30
  • Published Date: 2022-12-20
    Abstract
  • Acute pancreatitis (AP) is a common acute abdominal disease in gastroenterology. Severe patients tend to have high mortality and poor prognosis, and early evaluation of disease conditions and prediction of clinical outcome is of particular importance to improve the prognosis of patients. In recent years, great progress has been made in related markers for predicting the severity stratification and prognosis of patients with AP. This article reviews the value of immune indices, cytokines, genes, biochemical indices, imaging findings, and other related indicators in predicting the severity, mortality, and complications of AP.

     

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  • [1]
    JIN M, BAI X, CHEN X, et al. A 16-year trend of etiology in acute pancreatitis: The increasing proportion of hypertriglyceridemia-associated acute pancreatitis and its adverse effect on prognosis[J]. J Clin Lipidol, 2019, 13(6): 947-953.e1. DOI: 10.1016/j.jacl.2019.09.005.
    [2]
    CHENG Z, LIU Z, YUAN Y, et al. Predictive value of serum soluble B7-H4 in acute pancreatitis[J]. Eur J Clin Invest, 2020, 50(12): e13346. DOI: 10.1111/eci.13346.
    [3]
    XU R, GONG J, CHEN W, et al. Soluble B7-H5 is a novel diagnostic, severity, and prognosis marker in acute pancreatitis[J]. Biomed Res Int, 2021, 2021: 1223850. DOI: 10.1155/2021/1223850.
    [4]
    SUN S, CHEN Y, LIU Z, et al. Serum-soluble PD-L1 may be a potential diagnostic biomarker in sepsis[J]. Scand J Immunol, 2021, 94(1): e13049. DOI: 10.1111/sji.13049.
    [5]
    ZHAO Z, SHEN J, ZHANG D, et al. The prognostic role of peripheral lymphocyte subsets in patients with acute pancreatitis[J]. Am J Med Sci, 2019, 357(3): 242-246. DOI: 10.1016/j.amjms.2018.12.008.
    [6]
    PENG Y, ZHU X, HOU C, et al. Development an inflammation-related factor-based model for predicting organ failure in acute pancreatitis: A retrospective cohort study[J]. Mediators Inflamm, 2021, 2021: 4906768. DOI: 10.1155/2021/4906768.
    [7]
    PAN J, QIN YQ, LIANG YX, et al. Change of lymphocyte subsets in peripheral blood of patients with acute pancreatitis and its relationship with autophagy and apoptosis[J]. Chin J Immunol, 2020, 36(19): 2405-2410. DOI: 10.3969/j.issn.1000-484X.2020.19.025.

    潘静, 覃月秋, 梁运轩, 等. 急性胰腺炎患者外周血淋巴细胞亚群的改变及其与自噬、凋亡的关系[J]. 中国免疫学杂志, 2020, 36(19): 2405-2410. DOI: 10.3969/j.issn.1000-484X.2020.19.025.
    [8]
    ZHANG Y, CHENG B, WU ZW, et al. Serum soluble suppression of tumorigenicity 2 as a novel inflammatory marker predicts the severity of acute pancreatitis[J]. World J Gastroenterol, 2021, 27(38): 6489-6500. DOI: 10.3748/wjg.v27.i38.6489.
    [9]
    SHI XR, WU Q, CHENG X. Value of soluble suppression of tumorigenicity 2 and heart-type fatty acid-binding protein in evaluation of early myocardial injury and prognosis in patients with severe acute pancreatitis[J]. Guangxi Med J, 2020, 42(9): 1088-1091. DOI: 10.11675/j.issn.0253-4304.2020.09.08.

    石欣荣, 吴倩, 程雪. 可溶性致癌抑制因子2、心型脂肪酸结合蛋白评估重症急性胰腺炎患者早期心肌损伤及预后的价值[J]. 广西医学, 2020, 42(9): 1088-1091. DOI: 10.11675/j.issn.0253-4304.2020.09.08.
    [10]
    AKIMOTO M, MARUYAMA R, TAKAMARU H, et al. Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment[J]. Nat Commun, 2016, 7: 13589. DOI: 10.1038/ncomms13589.
    [11]
    MINKOV G, DIMITROV E, YOVTCHEVY, et al. Prognostic value of peripheral blood CD14+HLA-DR+ monocytes in patients with acute pancreatitis[J]. J Immunoassay Immunochem, 2021, 42(5): 478-492. DOI: 10.1080/15321819.2021.1903491.
    [12]
    BOSTRÖM P, WU J, JEDRYCHOWSKI MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J]. Nature, 2012, 481(7382): 463-468. DOI: 10.1038/nature10777.
    [13]
    REN Y, QIU M, ZHANG J, et al. Low serum irisin concentration is associated with poor outcomes in patients with acute pancreatitis, and irisin administration protects against experimental acute pancreatitis[J]. Antioxid Redox Signal, 2019, 31(11): 771-785. DOI: 10.1089/ars.2019.7731.
    [14]
    CHEN S, WANG L, GAO X, et al. Characterization of serum irisin in patients with severe acute pancreatitis[J]. Eur J Gastroenterol Hepatol, 2019, 31(8): 985-991. DOI: 10.1097/MEG.0000000000001454.
    [15]
    SAMANTA J, SINGH S, ARORA S, et al. Cytokine profile in prediction of acute lung injury in patients with acute pancreatitis[J]. Pancreatology, 2018, 18(8): 878-884. DOI: 10.1016/j.pan.2018.10.006.
    [16]
    SHEN D, TANG C, ZHU S, et al. Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis based on the revised Atlanta classification[J]. BMC Gastroenterol, 2021, 21(1): 34. DOI: 10.1186/s12876-020-01598-0.
    [17]
    RODRIGUEZ-NICOLAS A, MARTÍNEZ-CHAMORRO A, JIMÉNEZ P, et al. TH1 and TH2 cytokine profiles as predictors of severity in acute pancreatitis[J]. Pancreas, 2018, 47(4): 400-405. DOI: 10.1097/MPA.0000000000001006.
    [18]
    STERNBY H, HARTMAN H, THORLACIUS H, et al. The initial course of IL1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α with regard to severity grade in acute pancreatitis[J]. Biomolecules, 2021, 11(4): 591. DOI: 10.3390/biom11040591.
    [19]
    ZHOU J, ZHOU P, ZHANG Y, et al. Signal pathways and markers involved in acute lung injury induced by acute pancreatitis[J]. Dis Markers, 2021, 2021: 9947047. DOI: 10.1155/2021/9947047.
    [20]
    WANG YQ, ZHONG QM, WANG XM, et al. Analysis of the risk factors correlated with intraabdominal infection and variation in the levels of ET and MCP-1 in patients with acute pancreatitis[J]. Chin J Nosocomiol, 2020, 30(15): 2343-2346. DOI: 10.11816/cn.ni.2020-192163.

    王延庆, 钟清梅, 王雪梅, 等. 急性胰腺炎并发腹腔感染危险因素及ET、MCP-1水平变化分析[J]. 中华医院感染学杂志, 2020, 30(15): 2343-2346. DOI: 10.11816/cn.ni.2020-192163.
    [21]
    FARRELL PR, JONES EK, HORNUNG L, et al. Cytokine profile elevations on admission can determine risks of severe acute pancreatitis in children[J]. J Pediatr, 2021, 238: 33-41. e4. DOI: 10.1016/j.jpeds.2021.07.015.
    [22]
    ZHU QY, WANG MC, TAO QY, et al. Analysis of value of dynamic changes of monocyte chemotactic protein-1 and interleukin 8 in assessment of severity of acute pancreatitis[J]. Chin J General Surg, 2017, 26(10): 1365-1370. DOI: 10.3978/j.issn.1005-6947.2017.10.024.

    朱琼媛, 王明春, 陶清元, 等. 单核细胞趋化因子蛋白1、白细胞介素8的动态变化对急性胰腺炎严重度评估价值分析[J]. 中国普通外科杂志, 2017, 26(10): 1365-1370. DOI: 10.3978/j.issn.1005-6947.2017.10.024.
    [23]
    TAN Q, HU C, CHEN Z, et al. Growth differentiation factor 15 is an early predictor for persistent organ failure and mortality in acute pancreatitis[J]. Pancreatology, 2022, 22(2): 200-209. DOI: 10.1016/j.pan.2021.12.001.
    [24]
    PEREIRO P, LIBRÁN-PÉREZ M, FIGUERAS A, et al. Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator[J]. Dev Comp Immunol, 2020, 109: 103698. DOI: 10.1016/j.dci.2020.103698.
    [25]
    MIAO B, QI WJ, ZHANG SW, et al. miR-148a suppresses autophagy by down-regulation of IL-6/STAT3 signaling in cerulein-induced acute pancreatitis[J]. Pancreatology, 2019, 19(4): 557-565. DOI: 10.1016/j.pan.2019.04.014.
    [26]
    YAN Z, ZANG B, GONG X, et al. MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury[J]. Life Sci, 2020, 241: 117118. DOI: 10.1016/j.lfs.2019.117118.
    [27]
    WU KL, WANG LC, FU GH, et al. Expression and clinical significance of microRNA-21-3p and microRNA-551-5p in patients with acute pancreatitis[J]. Chin Critical Care Med, 2020, 32(4): 463-467. DOI: 10.3760/cma.j.cn121430-20200116-00134.

    吴开李, 王连臣, 符国宏, 等. 急性胰腺炎患者血浆miR-21-3p和miR-551-5p表达水平及临床意义[J]. 中华危重病急救医学, 2020, 32(4): 463-467. DOI: 10.3760/cma.j.cn121430-20200116-00134.
    [28]
    LI J, BU X, CHEN X, et al. Predictive value of long non-coding RNA intersectin 1-2 for occurrence and in-hospital mortality of severe acute pancreatitis[J]. J Clin Lab Anal, 2020, 34(5): e23170. DOI: 10.1002/jcla.23170.
    [29]
    LIU X, LIN Y. Long non-coding RNA plasmacytoma variant translocation 1 correlates with higher inflammation, multiple organ injury and mortality risk in acute pancreatitis, especially in severe acute pancreatitis[J]. Clin Res Hepatol Gastroenterol, 2022, 101870. DOI: 10.1016/j.clinre.2022.101870.
    [30]
    LIANG ZX, YANG ZH. Changes of plasma free mitochondrial DNA in the patients with acute pancreatitis and clinical significance[J]. Chin Critical Care Med, 2020, 40(10): 966-971. DOI: 10.3969/j.issn.1002-1949.2020.10.012.

    梁转霞, 杨泽华. 急性胰腺炎患者血浆游离线粒体DNA水平变化及临床意义[J]. 中国急救医学, 2020, 40(10): 966-971. DOI: 10.3969/j.issn.1002-1949.2020.10.012.
    [31]
    WU L, XU W, WANG F, et al. Plasma mtDNA Analysis aids in predicting pancreatic necrosis in acute pancreatitis patients: A pilot study[J]. Dig Dis Sci, 2018, 63(11): 2975-2982. DOI: 10.1007/s10620-018-5227-9.
    [32]
    SUN YM, GAO F, CHEN X, et al. The relationship between triglyceride level and the severity of acute hypertriglyceridemic pancreatitis in Chinese patients[J]. Turk J Gastroenterol, 2020, 31(9): 633-639. DOI: 10.5152/tjg.2020.18335.
    [33]
    PARK JM, SHIN SP, CHO SK, et al. Triglyceride and glucose (TyG) index is an effective biomarker to identify severe acute pancreatitis[J]. Pancreatology, 2020, 20(8): 1587-1591. DOI: 10.1016/j.pan.2020.09.018.
    [34]
    CHEN X, MA JL, ZHOU YL, et al. The early predictive value of triglyceride and glucose index (TyG index)in the severity of acute pancreatitis[J]. J China-Japan Friendship Hosp, 2021, 35(5): 280-283. DOI: 10.3969/j.issn.1001-0025.2021.05.006.

    陈旭, 马佳丽, 周玉玲, 等. 甘油三酯-葡萄糖指数对急性胰腺炎严重程度的早期预测价值[J]. 中日友好医院学报, 2021, 35(5): 280-283. DOI: 10.3969/j.issn.1001-0025.2021.05.006.
    [35]
    JIN D, TAN J, JIANG J, et al. The early predictive value of routine laboratory tests on the severity of acute pancreatitis patients in pregnancy: a retrospective study[J]. Sci Rep, 2020, 10(1): 10087. DOI: 10.1038/s41598-020-66921-x.
    [36]
    XIAO W, LIU W, YIN L, et al. Serum hydroxybutyrate dehydrogenase as an early predictive marker of the severity of acute pancreatitis: a retrospective study[J]. BMC Gastroenterol, 2020, 20(1): 393. DOI: 10.1186/s12876-020-01521-7.
    [37]
    ZHOU H, MEI X, HH X, et al. Severity stratification and prognostic prediction of patients with acute pancreatitis at early phase: A retrospective study[J]. Medicine (Baltimore), 2019, 98(16): e15275. DOI: 10.1097/MD.0000000000015275.
    [38]
    GRAVITO-SOARES M, GRAVITO-SOARES E, GOMES D, et al. Red cell distribution width and red cell distribution width to total serum calcium ratio as major predictors of severity and mortality in acute pancreatitis[J]. BMC Gastroenterol, 2018, 18(1): 108. DOI: 10.1186/s12876-018-0834-7.
    [39]
    KUAN LL, DENNISON AR, GARCEA G. Association of visceral adipose tissue on the incidence and severity of acute pancreatitis: A systematic review[J]. Pancreatology, 2020, 20(6): 1056-1061. DOI: 10.1016/j.pan.2020.05.027.
    [40]
    ZHANG T, LI T, HUANG YM, et al. Value of body fat parameters in predicting the severity of acute pancreatitis[J]. J Clin Hepatol, 2020, 36(12): 2761-2764. DOI: 10.3969/j.issn.1001-5256.2020.12.024.

    张婷, 李婷, 黄雨梅, 等. 体脂参数对急性胰腺炎严重程度的预测价值[J]. 临床肝胆病杂志, 2020, 36(12): 2761-2764. DOI: 10.3969/j.issn.1001-5256.2020.12.024.
    [41]
    JI T, LI X, ZHANG X, et al. Evaluation of the severity of hyperlipidemia pancreatitis using CT-measured visceral adipose tissue[J]. J Clin Gastroenterol, 2019, 53(7): e276-e283. DOI: 10.1097/MCG.0000000000001079.
    [42]
    XIE J, XU L, PAN Y, et al. Impact of visceral adiposity on severity of acute pancreatitis: a propensity score-matched analysis[J]. BMC Gastroenterol, 2019, 19(1): 87. DOI: 10.1186/s12876-019-1015-z.
    [43]
    KUMAR P, GUPTA P, RANA S. Thoracic complications of pancreatitis[J]. JGH Open, 2018, 3(1): 71-79. DOI: 10.1002/jgh3.12099.
    [44]
    LUIKEN I, EISENMANN S, GARBE J, et al. Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity[J]. PLoS One, 2022, 17(2): e0263739. DOI: 10.1371/journal.pone.0263739.
    [45]
    YAN G, LI H, BHETUWAL A, et al. Pleural effusion volume in patients with acute pancreatitis: a retrospective study from three acute pancreatitis centers[J]. Ann Med, 2021, 53(1): 2003-2018. DOI: 10.1080/07853890.2021.1998594.
    [46]
    CHEN J, WAN J, SHU W, et al. Association of serum levels of silent information regulator 1 with persistent organ failure in acute pancreatitis[J]. Dig Dis Sci, 2019, 64(11): 3173-3181. DOI: 10.1007/s10620-019-05647-x.
    [47]
    YANG H, ZHANG W, PAN H, et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity[J]. PLoS One, 2012, 7(9): e46364. DOI: 10.1371/journal.pone.0046364.
    [48]
    ZHANG Q, LI L, CHEN H, et al. Soluble urokinase plasminogen activator receptor associates with higher risk, advanced disease severity as well as inflammation, and might serve as a prognostic biomarker of severe acute pancreatitis[J]. J Clin Lab Anal, 2020, 34(3): e23097. DOI: 10.1002/jcla.23097.
    [49]
    LONG D, WANG Y, WANG H, et al. Correlation of serum and ascitic fluid soluble form urokinase plasminogen activator receptor levels with patient complications, disease severity, inflammatory markers, and prognosis in patients with severe acute pancreatitis[J]. Pancreas, 2019, 48(3): 335-342. DOI: 10.1097/MPA.0000000000001247.
    [50]
    ARONEN A, AITTONIEMI J, HUTTUNEN R, et al. Plasma level of soluble urokinase plasminogen activator receptor (suPAR) predicts long-term mortality after first acute alcohol-induced pancreatitis[J]. Eur J Intern Med, 2019, 64: 72-75. DOI: 10.1016/j.ejim.2019.04.007.
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