Clinical characteristics and prognosis of acute on chronic liver failure in patients with recompensatory hepatitis B cirrhosis

Lei LIU; Jing LIANG; Baiguo XU; Fei WANG; Jia LIAN; Yankai YANG

doi:10.3969/j.issn.1001-5256.2023.01.011

Volume 39 Issue 1

Jan. 2023

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Clinical characteristics and prognosis of acute on chronic liver failure in patients with recompensatory hepatitis B cirrhosis

DOI: 10.3969/j.issn.1001-5256.2023.01.011

Lei LIU^{1, 2},
Jing LIANG^{1, 2
,
,
,},
Baiguo XU^{1, 2},
Fei WANG^{1, 2},
Jia LIAN^{1, 2},
Yankai YANG²

1.
The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China
2.
Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital; Tianjin Key Laboratory of Artificial Cells; Tianjin Institute of Hepatobiliary Disease; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China

Research funding:

Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-034A);

Tianjin Health Project (TJWJ2022XK029)

More Information

Corresponding author: LIANG Jing, haolele77@sina.com(ORCID: 0000-0001-5114-9030)
Received Date: 2022-07-07
Accepted Date: 2022-08-26
Published Date: 2023-01-20

Abstract

Abstract

Objective To assess the clinical characteristics of acute-on-chronic liver failure in patients with recompensatory hepatitis B cirrhosis. Methods A total of 180 patients with acute-on-chronic liver failure hospitalized in Tianjin Third Central Hospital from September 2013 to September 2021 were retrospectively collected, with 110 patients had compensatory hepatitis B cirrhosis and 70 patients had compensatory hepatitis B cirrhosis and used as the control. Their causes, clinical biochemical indicators, complication rate, and prognosis were compared. The Chi-square test or Fisher's exact test was used for comparison of categorical variables between groups, and the Mann-Whitney U test was performed for analysis of the continuous variables. Kaplan-Meier curves and Log-rank test were used for survival of patients. Results The incidence of hepatorenal syndrome (χ²=4.618, P=0.032), infection (χ²=6.712, P=0.010), Cr (Z =-4.508, P < 0.001), and PCT (Z=-2.052, P=0.040) were all higher, whereas GGT (Z=-2.042, P=0.041), Na (Z=-2.001, P=0.045), FBS (Z=-3.065, P=0.002), and TC (Z=-4.268, P < 0.001) were all lower in the recompensation group than in the control group of patients. However, 90-day mortality rate (χ²=3.366, P=0.067) and 1-year mortality rate (χ²=1.893, P=0.169), 90-day survival (χ²=2.68, P=0.100), and 1-year survival (χ²=2.074, P=0.150) were not statistically significant difference. Conclusion Compared with compensatory hepatitis B cirrhosis, patients with recompensatory cirrhosis had an increased risk in developing hepatorenal syndrome, infection, and increased creatinine level after acute-on-chronic liver failure, although there was no statistically significant difference in 90-days and 1-year survival of patients.
- Hepatitis B,
- Liver Cirrhosis,
- Acute-On-Chronic Liver Failure,
- Prognosis

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References

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Clinical characteristics and prognosis of acute on chronic liver failure in patients with recompensatory hepatitis B cirrhosis

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Clinical characteristics and prognosis of acute on chronic liver failure in patients with recompensatory hepatitis B cirrhosis

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