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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 1
Jan.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(1): 211-217

Application and potential value of endogenous lipid mediators in liver failure

DOI: 10.3969/j.issn.1001-5256.2023.01.033
  • 1.

    Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China

  • 2.

    Second Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation of China (81960841);

National Science and Technology Major Project (2018ZX10725505-001-011);

Guangxi Science and technology project (2020GXNSFAA297098);

Guangxi University of Traditional Chinese Medicine Graduate Innovation project (YCXJ2021034)

More Information
  • Corresponding author: LONG Fuli, longfuli005@163.com (ORCID: 0000-0003-1196-2697)
  • Received Date: 2022-05-11
  • Accepted Date: 2022-06-16
  • Published Date: 2023-01-20
    Abstract
  • Liver failure is a common end-stage liver disease syndrome in clinical practice characterized by massive necrosis of hepatocytes leading to rapid liver failure, and it is currently believed that excessive inflammation and immune response are the core mechanisms of this disease. Endogenous lipid mediators are involved in the regulation of a variety of inflammatory processes, including initiation, maintenance, and regression, and eicosanoids and pro-decomposition lipid mediators, as well as their complex metabolic pathways and transduction signals, play a key role in the regulation of these processes. This article reviews the key role of endogenous lipid mediators in the pathophysiological mechanism of inflammation and immune dysfunction in liver failure and the potential significance and new therapeutic opportunities of lipid immune pathway in liver failure, in order to provide new ideas for the clinical diagnosis and treatment of liver failure.

     

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