Immune escape of hepatic echinococcosis based on the PD-1/PD-L1 signaling pathway

Kangjie YANG; Yongliang LU; Weijian E

doi:10.3969/j.issn.1001-5256.2023.01.034

Volume 39 Issue 1

Jan. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(1): 218-225

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Immune escape of hepatic echinococcosis based on the PD-1/PD-L1 signaling pathway

DOI: 10.3969/j.issn.1001-5256.2023.01.034

Kangjie YANG¹,
Yongliang LU^{2
,
,
,},
Weijian E^{2
,
,
,}

1.
School of Medicine, Qinghai University, Xining 810000, China
2.
Department of Clinical Laboratory, The Affiliated Hospital of Qinghai University, Xining 810000, China

Research funding:

Youth Scientific Research Foundation of 2021 (2021-QYY-9)

More Information

Corresponding author: LU Yongliang, 625196237@qq.com (ORCID: 0000-0003-1188-7033); E Weijian, 2218896582@qq.com (ORCID: 0000-0003-2000-7763)
Received Date: 2022-05-11
Accepted Date: 2022-07-06
Published Date: 2023-01-20

Abstract

Abstract

PD-1 and PD-L1 together constitute the stimulus signaling pathway of adaptive immune response, which has been widely used in the research on the mechanism of tumor immune escape and tumor therapy. At the same time, its signaling pathway has been proved to be closely associated with the immune escape of hepatic echinococcosis. This article reviews the chemical structures of PD-1 and PD-L1, the mechanism of the PD-1/PD-L1 signaling pathway, and the role of the PD-1/PD-L1 signaling pathway in immune escape of hepatic echinococcosis, i.e., the PD-1/PD-L1 signaling pathway is involved in immune escape of hepatic echinococcosis under three theories, so as to explore the immune escape of hepatic echinococcosis from a new perspective and provide a basis and ideas for the diagnosis and treatment of hepatic echinococcosis.
- Echinococcosis, Hepatic,
- Programmed Death 1,
- PD-1 Ligand,
- Tumor Escape

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References(49)

References

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Immune escape of hepatic echinococcosis based on the PD-1/PD-L1 signaling pathway

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Immune escape of hepatic echinococcosis based on the PD-1/PD-L1 signaling pathway

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