Distribution of traditional Chinese medicine syndrome types and elements in liver cirrhosis patients with dysplastic nodules: An analysis of 138 cases

Xiaoxiao YAO; Yaokun HAO; Zhun XIAO; Lan ZHANG; Suping MA; Wenxia ZHAO

doi:10.3969/j.issn.1001-5256.2023.02.015

Volume 39 Issue 2

Feb. 2023

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Distribution of traditional Chinese medicine syndrome types and elements in liver cirrhosis patients with dysplastic nodules: An analysis of 138 cases

DOI: 10.3969/j.issn.1001-5256.2023.02.015

Xiaoxiao YAO¹,
Yaokun HAO²,
Zhun XIAO²,
Lan ZHANG³,
Suping MA^{2
,
,
,},
Wenxia ZHAO^{2
,
,
,}

1.
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450046, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
3.
Nuclear Magnetic Resonance Room, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (82104772);

The Science and Technology Research Program of Henan Province (222102310502);

Special Project of Traditional Chinese Medicine Scientific Research of Henan Province (2018JDZX004);

Traditional Chinese Medicine Science Research Project of Henan Province (2022ZY2008)

More Information

Corresponding author: MA Suping, masuping@163.com (ORCID: 0000-0002-5398-4424); ZHAO Wenxia, zhao-wenxia@163.com (ORCID: 0000-0001-6666-9469)
Received Date: 2022-08-07
Accepted Date: 2022-11-02
Published Date: 2023-02-20

Abstract

Abstract

Objective To investigate the distribution of traditional Chinese medicine (TCM) syndrome types and elements in liver cirrhosis patients with dysplastic nodules (DN), and to provide a basis for exploring the connotation and pattern of TCM syndrome types of DN in liver cirrhosis. Methods A total of 138 patients who attended The First Affiliated Hospital of Henan University of Chinese Medicine from March 2013 to January 2021 and were diagnosed with liver cirrhosis and DN were enrolled. General data such as age of onset and sex were collected, as well as the data on etiology, TCM syndrome types, and Child-Pugh class for liver function, and the distribution characteristics of TCM syndrome types and elements were summarized. The chi-square test or the Fisher's exact test was used for comparison of categorical data between groups. Results The liver and the spleen were the main syndrome elements of disease location in liver cirrhosis patients with DN, accounting for 97.83% and 94.93%, respectively, followed by the kidney (23.91%); Qi deficiency and Qi stagnation were the main syndrome elements reflecting the nature of disease, accounting for 73.91% and 58.70%, respectively, followed by dampness (34.78%). The main TCM syndrome types included stagnation of liver Qi and spleen deficiency, damp-heat internal excess syndrome, blood stasis and toxin accumulation syndrome, and water-dampness retention syndrome, among which stagnation of liver Qi and spleen deficiency was more common and accounted for 58.70% (P < 0.05). There were no significant differences in TCM syndrome types between the patients with different sexes, ages, and etiologies (all P > 0.05). There was a significant difference in Child-Pugh class between the liver cirrhosis DN patients with different TCM syndrome types (χ²=34.320, P < 0.05), and Child-Pugh class A was more common in the patients with stagnation of liver Qi and spleen deficiency (59.8%), while Child-Pugh class C was more common in the patients with damp-heat internal excess syndrome (39.1%). Conclusion This article summarizes the distribution characteristics of common TCM syndrome types and elements of DN in liver cirrhosis, which provides a reference for the syndrome differentiation-based TCM treatment of DN in liver cirrhosis.
- Liver Cirrhosis,
- Dysplastic Nodule,
- Syndrome Type,
- Syndrome Element,
- Medicine, Chinese Traditional

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References(19)

References

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Distribution of traditional Chinese medicine syndrome types and elements in liver cirrhosis patients with dysplastic nodules: An analysis of 138 cases

DOI: 10.3969/j.issn.1001-5256.2023.02.015