Detection methods for hepatitis D antibodies: A comparative analysis

Zhenfeng ZHANG

doi:10.3969/j.issn.1001-5256.2023.04.003

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 751-757

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Detection methods for hepatitis D antibodies: A comparative analysis

DOI: 10.3969/j.issn.1001-5256.2023.04.003

Zhenfeng ZHANG^{,
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School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

Research funding:

Southern University of Science and Technology Scientific Research Startup Fund (Y011006113)

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Corresponding author: ZHANG Zhenfeng, zhangzf@sustech.edu.cn (ORCID: 0000-0002-0013-3685)
Received Date: 2023-02-20
Accepted Date: 2023-03-20
Published Date: 2023-04-20

Abstract

Abstract

Hepatitis D is a severe form of viral hepatitis caused by co-infection with hepatitis D virus (HDV) and hepatitis B virus (HBV) or superinfection of HDV in HBV carriers. There is still a huge gap in the diagnosis of hepatitis D due to insufficient emphasis on this disease for a long time. With the advances in related studies in recent years, the academia and the medical industry have gradually realized the harm of hepatitis D, and meanwhile, breakthroughs in drug development have also brought new opportunities for the treatment or even cure of hepatitis D. These advances greatly increase the demand for the diagnosis of hepatitis D. HDV antibodies are the key markers for the diagnosis of hepatitis D. This article summarizes and compares the detection methods for HDV antibodies including total HDV antibodies, IgG, and IgM and discusses related important issues, so as to understand the current status of the detection of HDV antibodies and provide a reference for developing better diagnostic tools for hepatitis D.
- Hepatitis Delta Virus,
- Hepatitis D,
- Hepatitis Antibodies,
- Diagnosis

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References(33)

References

[1]	RIZZETTO M, HAMID S, NEGRO F. The changing context of hepatitis D[J]. J Hepatol, 2021, 74(5): 1200-1211. DOI: 10.1016/j.jhep.2021.01.014.
[2]	PAPATHEODORIDI M, PAPATHEODORIDIS GV. Is hepatitis delta underestimated?[J]. Liver Int, 2021, 41(Suppl 1): 38-44. DOI: 10.1111/liv.14833.
[3]	STOCKDALE AJ, KREUELS B, HENRION M, et al. The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis[J]. J Hepatol, 2020, 73(3): 523-532. DOI: 10.1016/j.jhep.2020.04.008.
[4]	CHEN HY, SHEN DT, JI DZ, et al. Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis[J]. Gut, 2019, 68(3): 512-521. DOI: 10.1136/gutjnl-2018-316601.
[5]	MIAO Z, ZHANG S, OU X, et al. Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection[J]. J Infect Dis, 2020, 221(10): 1677-1687. DOI: 10.1093/infdis/jiz633.
[6]	URBAN S, NEUMANN-HAEFELIN C, LAMPERTICO P. Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease[J]. Gut, 2021, 70(9): 1782-1794. DOI: 10.1136/gutjnl-2020-323888.
[7]	SARIN SK, KUMAR M, LAU GK, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update[J]. Hepatol Int, 2016, 10(1): 1-98. DOI: 10.1007/s12072-015-9675-4.
[8]	European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection[J]. J Hepatol, 2017, 67(2): 370-398. DOI: 10.1016/j.jhep.2017.03.021.
[9]	LUCIFORA J, DELPHIN M. Current knowledge on hepatitis delta virus replication[J]. Antiviral Res, 2020, 179: 104812. DOI: 10.1016/j.antiviral.2020.104812.
[10]	LANGE M, ZARET D, KUSHNER T. Hepatitis delta: Current knowledge and future directions[J]. Gastroenterol Hepatol (N Y), 2022, 18(9): 508-520.
[11]	DÉNY P. Hepatitis delta virus genetic variability: from genotypes Ⅰ, Ⅱ, Ⅲ to eight major clades?[J]. Curr Top Microbiol Immunol, 2006, 307: 151-171. DOI: 10.1007/3-540-29802-9_8.
[12]	LE GAL F, BRICHLER S, DRUGAN T, et al. Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2, 152 clinical strains[J]. Hepatology, 2017, 66(6): 1826-1841. DOI: 10.1002/hep.29574.
[13]	YURDAYD₁N C, IDILMAN R, BOZKAYA H, et al. Natural history and treatment of chronic delta hepatitis[J]. J Viral Hepat, 2010, 17(11): 749-756. DOI: 10.1111/j.1365-2893.2010.01353.x.
[14]	FARCI P, NIRO GA. Clinical features of hepatitis D[J]. Semin Liver Dis, 2012, 32(3): 228-236. DOI: 10.1055/s-0032-1323628.
[15]	BRICHLER S, LE GAL F, NERI-PINTO F, et al. Serological and molecular diagnosis of hepatitis delta virus infection: results of a French national quality control study[J]. J Clin Microbiol, 2014, 52(5): 1694-1697. DOI: 10.1128/JCM.03521-13.
[16]	RICCO G, POPA DC, CAVALLONE D, et al. Quantification of serum markers of hepatitis B (HBV) and Delta virus (HDV) infections in patients with chronic HDV infection[J]. J Viral Hepat, 2018, 25(8): 911-919. DOI: 10.1111/jvh.12895.
[17]	WRANKE A, HEIDRICH B, ERNST S, et al. Anti-HDV IgM as a marker of disease activity in hepatitis delta[J]. PLoS One, 2014, 9(7): e101002. DOI: 10.1371/journal.pone.0101002.
[18]	GOWANS EJ, MACNAUGHTON TB, MICKAN L, et al. Use of recombinant hepatitis delta antigen in diagnostic assays for HDV antibody[J]. J Virol Methods, 1990, 27(1): 69-78. DOI: 10.1016/0166-0934(90)90147-8.
[19]	TSWANA SA, LAHER S. Detection of anti-delta antibodies among acute hepatitis B virus-infected patients[J]. J Med Virol, 1988, 25(4): 471-474. DOI: 10.1002/jmv.1890250410.
[20]	BEZEAUD A, ROSENSWAJG M, GUILLIN MC. Evaluation of five hepatitis delta virus marker assays for detection of antigen and antibody[J]. J Clin Microbiol, 1989, 27(12): 2880. DOI: 10.1128/jcm.27.12.2880-.1989.
[21]	SHATTOCK AG, MORRIS MC. Evaluation of commercial enzyme immunoassays for detection of hepatitis delta antigen and anti-hepatitis delta virus (HDV) and immunoglobulin M anti-HDV antibodies[J]. J Clin Microbiol, 1991, 29(9): 1873-1876. DOI: 10.1128/jcm.29.9.1873-1876.1991.
[22]	KUO YB, CHAO M, LEE YH, et al. New enzyme-linked immunosorbent assay for detection of antibodies against hepatitis delta virus using a hepatitis delta antigen derived from a Taiwanese clone and comparison to the Abbott radioimmunoassay[J]. Clin Vaccine Immunol, 2012, 19(5): 817-819. DOI: 10.1128/CVI.05687-11.
[23]	GOVINDARAJAN S, VALINLUCK B, LAKE-BAKKAR G. Evaluation of a commercial anti-delta EIA kit for detection of antibodies to hepatitis delta virus[J]. Am J Clin Pathol, 1991, 95(2): 240-241. DOI: 10.1093/ajcp/95.2.240.
[24]	DE ORY F, MINGUITO T, BALFAGÓN P, et al. Comparison of chemiluminescent immunoassay and ELISA for measles IgG and IgM[J]. APMIS, 2015, 123(8): 648-651. DOI: 10.1111/apm.12413.
[25]	LEMPP FA, ROGGENBACH I, NKONGOLO S, et al. A rapid point-of-care test for the serodiagnosis of hepatitis delta virus infection[J]. Viruses, 2021, 13(12): 2371. DOI: 10.3390/v13122371.
[26]	ROGGENBACH I, CHI X, LEMPP FA, et al. HDV seroprevalence in HBsAg-positive patients in China occurs in hotspots and is not associated with HCV mono-infection[J]. Viruses, 2021, 13(9): 1799. DOI: 10.3390/v13091799.
[27]	CHEN X, OIDOVSAMBUU O, LIU P, et al. A novel quantitative microarray antibody capture assay identifies an extremely high hepatitis delta virus prevalence among hepatitis B virus-infected mongolians[J]. Hepatology, 2017, 66(6): 1739-1749. DOI: 10.1002/hep.28957.
[28]	LU XX, YI Y, SU QD, et al. Expression and purification of recombinant hepatitis delta virus (HDV) antigen for use in a diagnostic ELISA for HDV infection using the high-density fermentation strategy in Escherichia coli[J]. Biomed Environ Sci, 2016, 29(6): 417-423. DOI: 10.3967/bes2016.054.
[29]	WANG W, LEMPP FA, SCHLUND F, et al. Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates[J]. J Hepatol, 2021, 75(2): 311-323. DOI: 10.1016/j.jhep.2021.03.025.
[30]	COLLER KE, BUTLER EK, LUK KC, et al. Development and performance of prototype serologic and molecular tests for hepatitis delta infection[J]. Sci Rep, 2018, 8(1): 2095. DOI: 10.1038/s41598-018-20455-5.
[31]	CHOW SK, ATIENZA EE, COOK L, et al. Comparison of enzyme immunoassays for detection of antibodies to hepatitis D virus in serum[J]. Clin Vaccine Immunol, 2016, 23(8): 732-734. DOI: 10.1128/CVI.00028-16.
[32]	LE GAL F, BRICHLER S, SAHLI R, et al. First international external quality assessment for hepatitis delta virus RNA quantification in plasma[J]. Hepatology, 2016, 64(5): 1483-1494. DOI: 10.1002/hep.28772.
[33]	ZHANG ZF, ZHUANG H. Research progress on laboratory diagnosis of hepatitis D[J]. Chin J Viral Dis, 2021, 11(6): 407-413. DOI: 10.16505/j.2095-0136.2021.0052. 张振锋, 庄辉. 丁型肝炎实验室诊断研究进展[J]. 中国病毒病杂志, 2021, 11(6): 407-413. DOI: 10.16505/j.2095-0136.2021.0052.

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Detection methods for hepatitis D antibodies: A comparative analysis

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Detection methods for hepatitis D antibodies: A comparative analysis

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