A new perspective in the treatment of liver fibrosis: Targeting macrophage metabolism

Jun XU; Weilin IN; Xun LI

doi:10.3969/j.issn.1001-5256.2023.04.027

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 922-928

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A new perspective in the treatment of liver fibrosis: Targeting macrophage metabolism

DOI: 10.3969/j.issn.1001-5256.2023.04.027

Jun XU¹,
Weilin IN^{1, 2a},
Xun LI^{1, 2a, 2b, 3
,
,
,}

1.
The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
2a.
Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, Lanzhou 730000, China
2b.
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, China
3.
Gansu Province Key Laboratory of Biotherapy and Regenerative Medicine, Lanzhou 730000, China

Research funding:

Regional Project of National Natural Science Foundation of China (82060119)

More Information

Corresponding author: LI Xun, Lxdr21@126.com (ORCID: 0000-0003-3787-1558)
Received Date: 2022-08-02
Accepted Date: 2022-09-21
Published Date: 2023-04-20

Abstract

Abstract

Liver fibrosis is a pathological process of fibrous scar formation caused by excessive accumulation of extracellular matrix due to various etiologies. At present, etiological treatment, such as effective antiviral therapy, is still the main treatment strategy for liver fibrosis. As the core participant of liver fibrosis, liver macrophages affect the progression and regression of liver fibrosis and are thus considered an important target for the treatment of liver fibrosis. With the recent advances in the field of immune metabolism, metabolic reprogramming has become a key factor for determining the outcome of macrophages and promoting the development of diseases. This article reviews the role and metabolic changes of macrophages during liver fibrosis and discusses the anti-fibrotic potential of targeting macrophage metabolism, so as to provide new ideas for the development, progression, and treatment of liver fibrosis.
- Liver Cirrhosis,
- Macrophages,
- Therapeutics

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References(52)

References

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A new perspective in the treatment of liver fibrosis: Targeting macrophage metabolism

DOI: 10.3969/j.issn.1001-5256.2023.04.027

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A new perspective in the treatment of liver fibrosis: Targeting macrophage metabolism

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