The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma

Zhen LI; Jiangkai LIU

doi:10.3969/j.issn.1001-5256.2023.04.032

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 956-960

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The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.04.032

Zhen LI¹,
Jiangkai LIU^{2
,
,
,}

1.
The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (Joint Fund) (U1504825);

Key Scientific Research Projects of Henan Province Colleges and Universities (20A360014);

Funded by Henan Province Traditional Chinese Medicine Top Talents Training Project (Yuwei Chinese Medicine Letter [2021] No.15)

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Corresponding author: LIU Jiangkai, xmlc001@126.com (ORCID: 0000-0002-1529-5089)
Received Date: 2022-07-30
Accepted Date: 2022-08-31
Published Date: 2023-04-20

Abstract

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and the development and progression of HCC is a complex pathological process. As a new way of cell death, ferroptosis has huge potential in the treatment of HCC. This article introduces the mechanism of action of the tumor suppressor p53 in regulating ferroptosis and briefly describes its role in the development and progression of HCC. The tumor suppressor p53 can promote or inhibit ferroptosis by affecting solute carrier family 7 member 11, spermidine/spermine N1-acety-ltransferase 1, glutaminase 2, dipeptidyl peptidase 4, and cyclin-dependent kinase inhibitor 1A, which in turn affects the progression of HCC. The treatment of HCC by regulating the ferroptosis pathway has great application prospects.
- Ferroptosis,
- Carcinoma, Hepatocellular,
- Tumor Suppressor Protein p53

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References(35)

References

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The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma

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The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma

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