中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 4
Apr.  2023
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Article Contents

Role of non-coding RNA on immune cells in tumor microenvironment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.04.033
Research funding:

Hebei Provincial Government Funded Clinical Medicine Talent Training Program (361007)

More Information
  • Corresponding author: YANG Jihong, doctoryangjh@sina.com (ORCID: 0000-0001-8844-8640)
  • Received Date: 2022-07-28
  • Accepted Date: 2022-09-09
  • Published Date: 2023-04-20
  • Hepatocellular carcinoma (HCC) is a common malignant tumor of the liver characterized by a high incidence rate, rapid progression, and poor prognosis. In recent years, it has been found that non-coding RNA (ncRNA) participates in the regulation of tumor immunity in tumor microenvironment (TME) and in turn affects the biological behavior of HCC. This article briefly describes the regulatory effect of ncRNA on immune cells in TME and introduces the potential value of ncRNA in the diagnosis and treatment of HCC, in order to provide potential diagnostic and treatment strategies for HCC.

     

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  • [1]
    SUNG H, FERLAY J, SIEGEL RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. DOI: 10.3322/caac.21660.
    [2]
    DING W, TAN YL, QIAN Y, et al. First-line targ veted therapies of advanced hepatocellular carcinoma: A Bayesian network analysis of randomized controlled trials[J]. PLoS One, 2020, 15(3): e0229492. DOI: 10.1371/journal.pone.0229492.
    [3]
    ANASTASIADOU E, JACOB LS, SLACK FJ. Non-coding RNA networks in cancer[J]. Nat Rev Cancer, 2018, 18(1): 5-18. DOI: 10.1038/nrc.2017.99.
    [4]
    AKBARI DILMAGHNAI N, SHOOREI H, SHARIFI G, et al. Non-coding RNAs modulate function of extracellular matrix proteins[J]. Biomed Pharmacother, 2021, 136: 111240. DOI: 10.1016/j.biopha.2021.111240.
    [5]
    SHI TT, MORISHITA A, KOBARA H, et al. The role of long non-coding RNA and microRNA networks in hepatocellular carcinoma and its tumor microenvironment[J]. Int J Mol Sci, 2021, 22(19): 10630. DOI: 10.3390/ijms221910630.
    [6]
    PU J, LI WC, WANG AM, et al. Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages[J]. Cell Death Dis, 2021, 12(12): 1103. DOI: 10.1038/s41419-021-04309-z.
    [7]
    GIRALDO NA, SANCHEZ-SALAS R, PESKE JD, et al. The clinical role of the TME in solid cancer[J]. Br J Cancer, 2019, 120(1): 45-53. DOI: 10.1038/s41416-018-0327-z.
    [8]
    PASCUT D, PRATAMA MY, VO NVT, et al. The crosstalk between tumor cells and the microenvironment in hepatocellular carcinoma: The role of exosomal microRNAs and their clinical implications[J]. Cancers, 2020, 12(4): 823. DOI: 10.3390/cancers12040823.
    [9]
    JIA ZM, JIA JL, YAO LH, et al. Crosstalk of exosomal non-coding RNAs in the tumor microenvironment: Novel frontiers[J]. Front Immunol, 2022, 13: 900155. DOI: 10.3389/fimmu.2022.900155.
    [10]
    XIA HM, HUANG ZY, LIU SQ, et al. Exosomal non-coding RNAs: Regulatory and therapeutic target of hepatocellular carcinoma[J]. Front Oncol, 2021, 11: 653846. DOI: 10.3389/fonc.2021.653846.
    [11]
    DIENER C, HART M, KEHL T, et al. Quantitative and time-resolved miRNA pattern of early human T cell activation[J]. Nucleic Acids Res, 2020, 48(18): 10164-10183. DOI: 10.1093/nar/gkaa788.
    [12]
    LIN YX, LIU S, SU L, et al. miR-570 inhibits proliferation, angiogenesis, and immune escape of hepatocellular carcinoma[J]. Cancer Biother Radiopharm, 2018, 33(6): 252-257. DOI: 10.1089/cbr.2017.2389.
    [13]
    HAN W, LI N, LIU J, et al. microRNA-26b-5p enhances T cell responses by targeting PIM-2 in hepatocellular carcinoma[J]. Cell Signal, 2019, 59: 182-190. DOI: 10.1016/j.cellsig.2018.11.011.
    [14]
    LI ZQ, WANG HY, ZENG QL, et al. p65/miR-23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma[J]. Cancer Med, 2020, 9(2): 711-723. DOI: 10.1002/cam4.2611.
    [15]
    WANG C, MA C, GONG LH, et al. Macrophage polarization and its role in liver disease[J]. Front Immunol, 2021, 12: 803037. DOI: 10.3389/fimmu.2021.803037.
    [16]
    LIU NN, WANG XM, STEER CJ, et al. microRNA-206 promotes the recruitment of CD8+ T cells by driving M1 polarisation of Kupffer cells[J]. Gut, 2022, 71(8): 1642-1655. DOI: 10.1136/gutjnl-2021-324170.
    [17]
    KE M, ZHANG Z, CONG L, et al. microRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis[J]. Biomed Pharmacother, 2019, 120: 109523. DOI: 10.1016/j.biopha.2019.109523.
    [18]
    PIÑEIRO FERNÁNDEZ J, LUDDY KA, HARMON C, et al. Hepatic tumor microenvironments and effects on NK cell phenotype and function[J]. Int J Mol Sci, 2019, 20(17): 4131. DOI: 10.3390/ijms20174131.
    [19]
    ZHANG QF, YIN WW, XIA Y, et al. Liver-infiltrating CD11b-CD27- NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression[J]. Cell Mol Immunol, 2017, 14(10): 819-829. DOI: 10.1038/cmi.2016.28.
    [20]
    SU ZX, YE XP, SHANG LM. miR-506 promotes natural killer cell cytotoxicity against human hepatocellular carcinoma cells by targeting STAT3[J]. Yonsei Med J, 2019, 60(1): 22-29. DOI: 10.3349/ymj.2019.60.1.22.
    [21]
    CHEN EB, ZHOU ZJ, XIAO K, et al. The miR-561-5p/CX3CL1 signaling axis regulates pulmonary metastasis in hepatocellular carcinoma involving CX3CR1+ natural killer cells infiltration[J]. Theranostics, 2019, 9(16): 4779-4794. DOI: 10.7150/thno.32543.
    [22]
    ZOU H, SHAO CX, ZHOU QY, et al. The role of lncRNAs in hepatocellular carcinoma: Opportunities as novel targets for pharmacological intervention[J]. Expert Rev Gastroenterol Hepatol, 2016, 10(3): 331-340. DOI: 10.1586/17474124.2016.1116382.
    [23]
    YU Z, ZHAO H, FENG X, et al. Long non-coding RNA FENDRR acts as a miR-423-5p sponge to suppress the treg-mediated immune escape of hepatocellular carcinoma cells[J]. Mol Ther Nucleic Acids, 2019, 17: 516-529. DOI: 10.1016/j.omtn.2019.05.027.
    [24]
    YAN K, FU Y, ZHU N, et al. Repression of lncRNA NEAT1 enhances the antitumor activity of CD8+T cells against hepatocellular carcinoma via regulating miR-155/Tim-3[J]. Int J Biochem Cell Biol, 2019, 110: 1-8. DOI: 10.1016/j.biocel.2019.01.019.
    [25]
    WANG YK, YANG L, DONG XC, et al. Overexpression of NNT-AS1 activates TGF- β signaling to decrease tumor CD4 lymphocyte infiltration in hepatocellular carcinoma[J]. Biomed Res Int, 2020, 2020: 8216541. DOI: 10.1155/2020/8216541.
    [26]
    WAN S, ZHAO E, KRYCZEK I, et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells[J]. Gastroenterology, 2014, 147(6): 1393-1404. DOI: 10.1053/j.gastro.2014.08.039.
    [27]
    BAIG MS, ROY A, RAJPOOT S, et al. Tumor-derived exosomes in the regulation of macrophage polarization[J]. Inflamm Res, 2020, 69(5): 435-451. DOI: 10.1007/s00011-020-01318-0.
    [28]
    LUO HL, LUO T, LIU JJ, et al. Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway[J]. Cancer Cell Int, 2021, 21(1): 422. DOI: 10.1186/s12935-021-02133-1.
    [29]
    TIAN XH, WU YY, YANG YT, et al. Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β-catenin signaling[J]. Mol Oncol, 2020, 14(2): 462-483. DOI: 10.1002/1878-0261.12606.
    [30]
    YE YB, XU Y, LAI Y, et al. Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization[J]. J Cell Biochem, 2018, 119(3): 2951-2963. DOI: 10.1002/jcb.26509.
    [31]
    SASAKI R, KANDA T, YOKOSUKA O, et al. Exosomes and hepatocellular carcinoma: From bench to bedside[J]. Int J Mol Sci, 2019, 20(6): 1406. DOI: 10.3390/ijms20061406.
    [32]
    QI F, DU XJ, ZHAO ZY, et al. Tumor mutation burden-associated LINC00638/miR-4732-3p/ULBP1 axis promotes immune escape via PD-L1 in hepatocellular carcinoma[J]. Front Oncol, 2021, 11: 729340. DOI: 10.3389/fonc.2021.729340.
    [33]
    ZHANG L, HU SS, CHEN JS, et al. Comprehensive analysis of the MIR4435-2HG/miR-1-3p/MMP9/miR-29-3p/DUXAP8 ceRNA network axis in hepatocellular carcinoma[J]. Discov Oncol, 2021, 12(1): 38. DOI: 10.1007/s12672-021-00436-3.
    [34]
    FANG PP, XIANG LX, CHEN WL, et al. LncRNA GAS5 enhanced the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3[J]. Innate Immun, 2019, 25(2): 99-109. DOI: 10.1177/1753425919827632.
    [35]
    CHEN W, QUAN Y, FAN S, et al. Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression[J]. Cancer Lett, 2020, 475: 119-128. DOI: 10.1016/j.canlet.2020.01.022.
    [36]
    WANG XX, SHENG W, XU T, et al. CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway[J]. Aging, 2021, 13(8): 11969-11987. DOI: 10.18632/aging.202900.
    [37]
    ZHANG PF, GAO C, HUANG XY, et al. Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma[J]. Mol Cancer, 2020, 19(1): 110. DOI: 10.1186/s12943-020-01222-5.
    [38]
    WANG Y, GAO RF, LI JP, et al. Downregulation of hsa_circ_0074854 suppresses the migration and invasion in hepatocellular carcinoma via interacting with HuR and via suppressing exosomes-mediated macrophage M2 polarization[J]. Int J Nanomedicine, 2021, 16: 2803-2818. DOI: 10.2147/IJN.S284560.
    [39]
    TANG X, REN H, GUO M, et al. Review on circular RNAs and new insights into their roles in cancer[J]. Comput Struct Biotechnol J, 2021, 19: 910-928. DOI: 10.1016/j.csbj.2021.01.018.
    [40]
    SHI Y, LIU JB, DENG J, et al. The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma[J]. Hereditas, 2021, 158(1): 44. DOI: 10.1186/s41065-021-00208-7.
    [41]
    CHEN WL, XU XM. New progress in the study of markers for the early diagnosis of liver cancer[J]. China Med Herald, 2023, 20(1): 40-44. DOI: 10.20047/j.issn1673-7210.2023.01.08.

    陈文亮, 徐细明. 肝癌早期诊断标志物的研究新进展[J]. 中国医药导报, 2023, 20(1): 40-44. DOI: 10.20047/j.issn1673-7210.2023.01.08.
    [42]
    HUANG FX, LI HY, LI ZK, et al. Regulation of thymosinα1 resistance to hepatocellular carcinoma by long chain non-coding RNA LINC0110[J]. Chin J Immunol, 2022, 38(10): 1207-1211. DOI: 10.3969/j.issn.1000-484X.2022.10.010.5

    黄凤霞, 李海燕, 李正堃, 等. 长链非编码RNA LINC01105调控肝癌对胸腺素α1耐药[J]. 中国免疫学杂志, 2022, 38(10): 1207-1211. DOI: 10.3969/j.issn.1000-484X.2022.10.010.5
    [43]
    SUN QY, LI J, JIN BX, et al. Evaluation of miR-331-3p and miR-23b-3p as serum biomarkers for hepatitis C virus-related hepatocellular carcinoma at early stage[J]. Clin Res Hepatol Gastroenterol, 2020, 44(1): 21-28. DOI: 10.1016/j.clinre.2019.03.011.
    [44]
    HUANG WJ, TIAN XP, BI SX, et al. The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis[J]. Oncogene, 2020, 39(23): 4538-4550. DOI: 10.1038/s41388-020-1307-3.
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