Association between endoplasmic reticulum stress and ferroptosis in liver diseases

Lu YE; Xiuqin LI; Jianqing WANG

doi:10.3969/j.issn.1001-5256.2023.04.036

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 980-985

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Association between endoplasmic reticulum stress and ferroptosis in liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.04.036

Lu YE^{1, 2, 3},
Xiuqin LI^{1, 2},
Jianqing WANG^{1, 2
,
,
,}

1.
Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230012, China
2.
Anhui Public Health Clinical Center, Hefei 230012, China
3.
School of Pharmacy, Anhui Medical University, Hefei 230032, China

Research funding:

National Natural Science Foundation of China (82073566);

The Program of Excellent Young Talents in Universities of Anhui Province (gxyq2019014);

Clinical Pharmacy and Pharmacology (2020)

More Information

Corresponding author: WANG Jianqing, jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)
Received Date: 2022-08-24
Accepted Date: 2022-10-08
Published Date: 2023-04-20

Abstract

Abstract

Research on the pathogenesis of liver diseases has attracted great attention. Endoplasmic reticulum stress (ERS) is a self-protective mechanism of cells, but sustained and severe ERS can induce apoptosis, autophagy, and ferroptosis, among which ferroptosis has been a research hotspot in recent years. Ferroptosis is mainly characterized by the accumulation of iron-dependent lipid peroxides and plays a key role in the development and progression of liver diseases, but there are currently few studies on the involvement of ERS in ferroptosis in liver diseases. This article summarizes the research advances in ERS-related signaling pathways, the mechanism of ferroptosis, and the involvement of ERS in liver diseases, so as to provide more ideas for research on the treatment of liver diseases.
- Liver Diseases,
- Endoplasmic Reticulum Stress,
- Ferroptosis

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References(36)

References

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Association between endoplasmic reticulum stress and ferroptosis in liver diseases

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Association between endoplasmic reticulum stress and ferroptosis in liver diseases

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