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Volume 39 Issue 5
May  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(5): 1144-1149

Histopathological characteristics of the liver in children with non-alcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2023.05.021
  • a.

    Department of Pathology, Hunan Children's Hospital, Changsha 410000, China

  • b.

    Liver Disease Center, Hunan Children's Hospital, Changsha 410000, China

Research funding:

Research Project Plan of Hunan Provincial Health Commission (202206014267)

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  • Corresponding author: LI Shuangjie, 2273858951@qq.com(ORCID: 0000-0002-3792-6793)
  • Received Date: 2022-09-02
  • Accepted Date: 2022-11-09
  • Published Date: 2023-05-20
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    • References(34)
  • [1]
    YOUNOSSI Z, ANSTEE QM, MARIETTI M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention[J]. Nat Rev Gastroenterol Hepatol, 2018, 15(1): 11-20. DOI: 10.1038/nrgastro.2017.109.
    [2]
    ZHANG YP, ZHU YB, YAO Y, et al. Association of high-fructose high-salt diet with metabolic syndrome[J]. J Clin Exp Med, 2022, 21(15): 1569-1572. DOI: 10.3969/j.issn.1671-4695.2022.15.001.

    张雅娉, 朱耀斌, 高琰, 等. 高果糖高盐饮食与代谢综合征的关系研究[J]. 临床和实验医学杂志, 2022, 21(15): 1569-1572. DOI: 10.3969/j.issn.1671-4695.2022.15.001.
    [3]
    ESTES C, ANSTEE QM, ARIAS-LOSTE MT, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030[J]. J Hepatol, 2018, 69(4): 896-904. DOI: 10.1016/j.jhep.2018.05.036.
    [4]
    ESLAM M, NEWSOME PN, SARIN SK, et al. A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement[J]. J Hepatol, 2020, 73(1): 202-209. DOI: 10.1016/j.jhep.2020.03.039.
    [5]
    XIAO QQ, WANG MY, FAN JG. Brief introduction of APASL clinical practice guidelines on metabolic associated fatty liver disease(Treatment Part)[J]. J Clin Hepatol, 2021, 37(1): 41-45. DOI: 10.3696/j.issn.1001-5256.2021.01.009.

    肖倩倩, 王梦雨, 范建高. 亚太肝病研究学会代谢相关脂肪性肝病临床诊疗指南(治疗部分)简介[J]. 临床肝胆病杂志, 2021, 37(1): 41-45. DOI: 10.3696/j.issn.1001-5256.2021.01.009.
    [6]
    OZTURK Y, SOYLU OB. Fatty liver in childhood[J]. World J Hepatol, 2014, 6(1): 33-40. DOI: 10.4254/wjh.v6.i1.33.
    [7]
    SIMON TG, ROELSTRAETE B, HARTJES K, et al. Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality[J]. J Hepatol, 2021, 75(5): 1034-1041. DOI: 10.1016/j.jhep.2021.06.034.
    [8]
    Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association. Consensus on the diagnosis and therapy of hepatic fibrosis(2019)[J]. J Clin Hepatol, 2019, 35(10): 2163-2172. DOI: 10.3969/j.issn.1001-5256.2019.10.007.

    中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会. 肝纤维化诊断及治疗共识(2019年)[J]. 临床肝胆病杂志, 2019, 35(10): 2163-2172. DOI: 10.3969/j.issn.1001-5256.2019.10.007.
    [9]
    VOS MB, ABRAMS SH, BARLOW SE, et al. NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)[J]. J Pediatr Gastroenterol Nutr, 2017, 64(2): 319-334. DOI: 10.1097/MPG.0000000000001482.
    [10]
    KLEINER DE, BRUNT EM, VAN NATTA M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease[J]. Hepatology, 2005, 41(6): 1313-1321. DOI: 10.1002/hep.20701.
    [11]
    SCHWIMMER JB, BEHLING C, NEWBURY R, et al. Histopathology of pediatric nonalcoholic fatty liver disease[J]. Hepatology, 2005, 42(3): 641-649. DOI: 10.1002/hep.20842.
    [12]
    KLEINER DE, BRUNT EM. Nonalcoholic fatty liver disease: pathologic patterns and biopsy evaluation in clinical research[J]. Semin Liver Dis, 2012, 32(1): 3-13. DOI: 10.1055/s-0032-1306421.
    [13]
    ANDERSON EL, HOWE LD, JONES HE, et al. The prevalence of non-alcoholic fatty liver disease in children and adolescents: A systematic review and meta-analysis[J]. PLoS One, 2015, 10(10): e0140908. DOI: 10.1371/journal.pone.0140908.
    [14]
    DISTEFANO JK. NAFLD and NASH in postmenopausal women: Implications for diagnosis and treatment[J]. Endocrinology, 2020, 161(10): bqaa134. DOI: 10.1210/endocr/bqaa134.
    [15]
    WEIHE P, WEIHRAUCH-BLVHER S. Metabolic syndrome in children and adolescents: diagnostic criteria, therapeutic options and perspectives[J]. Curr Obes Rep, 2019, 8(4): 472-479. DOI: 10.1007/s13679-019-00357-x.
    [16]
    WANG CE, XU WT, GONG J, et al. Treatment of patients with nonalcoholic fatty liver disease[J]. Clin J Med Offic, 2022, 50(9): 897-899, 903. DOI: 10.16680/j.1671-3826.2022.09.06.

    王彩娥, 许文涛, 宫建, 等. 非酒精性脂肪性肝病治疗研究进展[J]. 临床军医杂志, 2022, 50(9): 897-899, 903. DOI: 10.16680/j.1671-3826.2022.09.06.
    [17]
    MANCO M, MARCELLINI M, DEVITO R, et al. Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis[J]. Int J Obes (Lond), 2008, 32(2): 381-387. DOI: 10.1038/sj.ijo.0803711.
    [18]
    DOYCHEVA I, WATT KD, ALKHOURI N. Nonalcoholic fatty liver disease in adolescents and young adults: The next frontier in the epidemic[J]. Hepatology, 2017, 65(6): 2100-2109. DOI: 10.1002/hep.29068.
    [19]
    GUO ZQ, WANG QY, QI XS, et al. Recommendations for the diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases (2017)[J]. J Clin Hepatol, 2017, 33(12): 2275-2277. DOI: 10.3969/j.issn.1001-5256.2017.12.003.

    郭泽淇, 王倩怡, 祁兴顺, 等. 《2017年美国肝病学会非酒精性脂肪性肝病诊疗指导》摘译[J]. 临床肝胆病杂志, 2017, 33(12): 2275-2277. DOI: 10.3969/j.issn.1001-5256.2017.12.003.
    [20]
    KLEINER DE, MAKHLOUF HR. Histology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adults and children[J]. Clin Liver Dis, 2016, 20(2): 293-312. DOI: 10.1016/j.cld.2015.10.011.
    [21]
    SEKI S, KITADA T, YAMADA T, et al. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases[J]. J Hepatol, 2002, 37(1): 56-62. DOI: 10.1016/s0168-8278(02)00073-9.
    [22]
    CHALASANI N, WILSON L, KLEINER DE, et al. Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease[J]. J Hepatol, 2008, 48(5): 829-834. DOI: 10.1016/j.jhep.2008.01.016.
    [23]
    WANG K, SUN C, DONG C, et al. Analysis of de novo non-alcoholic fatty liver disease in early period after pediatric liver transplantation: a report of 8 cases[J]. Chin J Organ Transplant, 2021, 42(9): 534-538. DOI: 10.3760/cma.j.cn421203-20200728-00261.

    王凯, 孙超, 董冲, 等. 儿童肝移植术后早期新发非酒精性脂肪性肝病八例临床分析[J]. 中华器官移植杂志, 2021, 42(9): 534-538. DOI: 10.3760/cma.j.cn421203-20200728-00261.
    [24]
    WANG XY, WANG LF. Pathological diagnosis of nonalcoholic steatohepatitis[J]. J Prac Hepatol, 2013, 16(6): 486-489. DOI: 10.3969/j.issn.1672-5069.2013.06.003.

    王晓颖, 王立峰. 非酒精性脂肪性肝炎的病理学诊断[J]. 实用肝脏病杂志, 2013, 16(6): 486-489. DOI: 10.3969/j.issn.1672-5069.2013.06.003.
    [25]
    TAKAHASHI Y, INUI A, FUJISAWA T, et al. Histopathological characteristics of non-alcoholic fatty liver disease in children: Comparison with adult cases[J]. Hepatol Res, 2011, 41(11): 1066-1074. DOI: 10.1111/j.1872-034X.2011.00855.x.
    [26]
    SKOIEN R, RICHARDSON MM, JONSSON JR, et al. Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways[J]. Liver Int, 2013, 33(4): 624-632. DOI: 10.1111/liv.12100.
    [27]
    CARTER-KENT C, YERIAN LM, BRUNT EM, et al. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study[J]. Hepatology, 2009, 50(4): 1113-1120. DOI: 10.1002/hep.23133.
    [28]
    SINGH S, ALLEN AM, WANG Z, et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies[J]. Clin Gastroenterol Hepatol, 2015, 13(4): 643-654. e1-e9; quiz e39-e40. DOI: 10.1016/j.cgh.2014.04.014.
    [29]
    KANWAR P, KOWDLEY KV. The metabolic syndrome and its influence on nonalcoholic steatohepatitis[J]. Clin Liver Dis, 2016, 20(2): 225-243. DOI: 10.1016/j.cld.2015.10.002.
    [30]
    WANG LM, ZHANG HF, DONG Y, et al. Clinical and pathological characteristics of nonalcoholic steatohepatitis in children[J]. Chin J Pract Pediatr, 2014, 29(12): 932-935. DOI: 10.7504/ek2014120612.

    王丽旻, 张鸿飞, 董漪, 等. 儿童非酒精性脂肪性肝炎临床与病理特点分析[J]. 中国实用儿科杂志, 2014, 29(12): 932-935. DOI: 10.7504/ek2014120612.
    [31]
    ZHU HH, ZHENG RD, MENG JR, et al. Pathological characteristics of nonalcoholic fatty liver disease[J]. Chin Hepatol, 2007, 12(1): 10-12. DOI: 10.14000/j.cnki.issn.1008-1704.2007.01.005.

    朱皓皞, 郑瑞丹, 孟加榕, 等. 非酒精性脂肪性肝病的病理特点分析[J]. 肝脏, 2007, 12(1): 10-12. DOI: 10.14000/j.cnki.issn.1008-1704.2007.01.005.
    [32]
    ZHOU XL, FU JF. Expert consensus on diagnosis and treatment of nonalcoholic fatty liver disease in children[J]. Chin J Pract Pediatr, 2018, 33(7): 487-492. DOI: 10.19538/j.ek2018070602.

    周雪莲, 傅君芬. 儿童非酒精性脂肪肝病诊断与治疗专家共识[J]. 中国实用儿科杂志, 2018, 33(7): 487-492. DOI: 10.19538/j.ek2018070602.
    [33]
    PATTON HM, LAVINE JE, van NATTA ML, et al. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis[J]. Gastroenterology, 2008, 135(6): 1961-1971. e2. DOI: 10.1053/j.gastro.2008.08.050.
    [34]
    ABDELMALEK MF, SUZUKI A, GUY C, et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease[J]. Hepatology, 2010, 51(6): 1961-1971. DOI: 10.1002/hep.23535.
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