Research advances in immunotherapy for hepatocellular carcinoma

Lizhen ZHU; Xiaolei XU; ABUDUSALAMU Aini; Xiaojuan WANG; Hu ZHOU; Rui TANG; Haining FAN; Qian LU

doi:10.3969/j.issn.1001-5256.2023.05.031

Volume 39 Issue 5

May 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(5): 1197-1203

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Research advances in immunotherapy for hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.05.031

Lizhen ZHU^{1, 2},
Xiaolei XU^{2, 3},
ABUDUSALAMU Aini⁴,
Xiaojuan WANG⁴,
Hu ZHOU^{2, 3},
Rui TANG⁴,
Haining FAN²,
Qian LU^{2, 3, 4
,
,}

1.
Graduate School of Qinghai University, Xining 810001, China
2.
Department of Hepatopancreatobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining 810000, China
3.
School of Clinical Medicine, Tsinghua University, Beijing 100000, China
4.
Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China

Research funding:

Tsinghua University Institute of Intelligent Medicine (10001020108);

Tsinghua University Presision Medicine Research Program (2022ZLA003);

Youth and Middle aged Project of Affiliated Hospital of Qinghai University (ASRF-2021-YB-17)

More Information

Corresponding author: LU Qian, luqianbtch@163.com (ORCID: 0000-0002-3597-9656)
Received Date: 2022-11-23
Accepted Date: 2022-12-29
Published Date: 2023-05-20

Abstract

Abstract

Hepatocellular carcinoma (HCC) has an insidious onset, and most patients are in the advanced stage when attending the hospital and thus lose the opportunity for radical surgical resection, which results in the poor prognosis of patients. With the development of clinical treatment, the treatment of advanced HCC has gradually transitioned from the relatively single and limited treatment options in the past to the new model of comprehensive treatment. In recent years, immunotherapy, represented by immune checkpoint inhibitors (ICIs), has become widely used in clinical practice. At present, a number of clinical studies have been conducted for immunotherapy combined with local and targeted antitumor therapy, and in particular, ICIs combined with targeted therapy have become a research hotspot in the field of HCC treatment. This article reviews the research advances in immunotherapy for the treatment of HCC.
- Carcinoma, Hepatocellular,
- Immunotherapy,
- Molecular Targeted Therapy

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References(41)

References

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Research advances in immunotherapy for hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.05.031

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Research advances in immunotherapy for hepatocellular carcinoma

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