Research advances in mesenchymal stem cells and their exosomes in treatment of autoimmune hepatitis

Longlong LUO; Lifei WANG; Ying ZHENG; Bin LI; Lixia LU; Chuyi LI; Xiaohui YU; Jiucong ZHANG

doi:10.3969/j.issn.1001-5256.2023.12.025

Volume 39 Issue 12

Dec. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(12): 2920-2925

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Research advances in mesenchymal stem cells and their exosomes in treatment of autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2023.12.025

Longlong LUO^{1, 2},
Lifei WANG^{1, 2},
Ying ZHENG²,
Bin LI^{2
,
,
,},
Lixia LU²,
Chuyi LI²,
Xiaohui YU²,
Jiucong ZHANG^{2
,
,
,}

1.
The First Clinical Medical School，Gansu University of Chinese Medicine，Lanzhou 730000，China
2.
Department of Gastroenterology，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China

Research funding:

Gansu Clinical Medical Research Center for Non-infectious Liver Diseases (21JR7RA017);

Liver Disease Diagnosis and Treatment Center, 940th Hospital Foundation, Joint Logistics Support Force (2021yxky079);

Gansu Province Science and Technology Plan Project Assignment (22YF7FA105);

Gansu Province Health Industry Scientific Research Plan Project Contract (GSWSKY2021-054)

More Information

Corresponding author: LI Bin， 2312115338@qq.com （ORCID： 0000-0002-8626-7624）; ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）
Received Date: 2023-02-25
Accepted Date: 2023-04-15
Published Date: 2023-12-12

Abstract

Abstract

Autoimmune hepatitis （AIH） is a type of chronic hepatitis caused by the autoimmune system attacking hepatocytes， and its chronic progression may lead to liver cirrhosis and even hepatocellular carcinoma. Currently， pharmacotherapy and liver transplantation are the main treatment methods for AIH， but both methods have their own limitations， which limits the clinical benefits of patients. Therefore， it is a critical issue to search for new therapeutic agents and methods. Recent studies have shown that mesenchymal stem cells （MSC） and their exosomes can improve the symptoms of patients with AIH by suppressing inflammatory response， enhancing the regeneration of hepatocytes， and regulating the immune system and thus have wide application prospects in the treatment of AIH. By summarizing related articles， this article reviews the possible mechanisms and application of MSC and their exosomes in the treatment of AIH， in order to provide new ideas for the clinical treatment of AIH.
- Hepatitis， Autoimmune,
- Mesenchymal Stem Cells,
- Exosomes,
- Therapeutics

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References(41)

References

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Research advances in mesenchymal stem cells and their exosomes in treatment of autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2023.12.025

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Research advances in mesenchymal stem cells and their exosomes in treatment of autoimmune hepatitis

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