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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 12
Dec.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(12): 2932-2941

Research advances in signaling pathways associated with potential anti-liver fibrosis drugs and targets

DOI: 10.3969/j.issn.1001-5256.2023.12.027
  • 1.

    Graduate School of Hebei Medical University，Shijiazhuang 050017，China

  • 2.

    Department of Pharmacy，Hebei General Hospital，Shijiazhuang 050057，China

Research funding:

Project of Health Commission of Hebei Province (20210037)

More Information
  • Corresponding author: DONG Zhanjun， 13313213656@126.com （ORCID： 0000-0001-5349-4970）
  • Received Date: 2023-03-13
  • Accepted Date: 2023-05-09
  • Published Date: 2023-12-12
    Abstract
  • Liver fibrosis is a key step in the progression of chronic liver diseases to liver cirrhosis and even liver cancer. In recent years， a large number of studies have shown the necessity of intervening in the process of liver fibrosis， and various anti-liver fibrosis drugs and active ingredients have been discovered. Non-coding RNAs also play an important role in the process of liver fibrosis， and searching for upstream non-coding RNAs that can regulate signaling pathways can provide new insights for anti-liver fibrosis treatment. This article introduces the process of liver fibrosis mediated by the TGF-β， Wnt/β-catenin， PI3K/Akt/mTOR， NF-κβ， Hippo， and MAPK signaling pathways， lists the latest anti-liver fibrosis drugs or active components in each signaling pathway， and summarizes the research advances in anti-liver fibrosis targets and drugs mediated by related non-coding RNAs， so as to provide new research ideas and treatment methods for anti-liver fibrosis treatment.

     

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