纤溶活化指标变化对肝硬化患者的影响

WT5”BZ] To investigate the function of fibrinolysis in patients with cirrhosis, Plasminogen activator inhibitor-A (PAI-A) 、tissue-type plasminogen activator-A (t-PA:A) and t-PA:Ag were assayed by chromogenic assay, D-dimer was assayed by ELISA.These targets were assayed in 37 healthy volunteers and 68 patients with cirrhosis (36 in compensatory stage and 32 in incompensatory stage) .Results:t-PA:A、t-PA:Ag and D-dimer in serum concentration were significant higher in cirrhosis group than healthy volunteers group, they were also significant higher in incompensatory cirrhosis group than compensatory cirrhosis group, PAI-A was by contrary in incompensotory cirrhosis group, compensatory cirrhosis group and healthy volunteers group. Conclusions:Hyperfibrinolysis is signifirance in cirrhosis patients in different degree. [WT5”HZ]