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Apr.  2000
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Article Navigation >  Journal of Clinical Hepatology  > 2000  >  16(4): 241-243

糖尿病人肝脏的超微结构研究

  • Published Date: 2000-04-20
    Abstract
  • Objective:To study the changes of hepatic ultrastructure in patients with diabetes mellitus.Methods:Liver biopsy and pathological examination were carried out in 20 diabetes mellitus patients.Result Under light microscope, It showed that nuclear glycogen cavity, fatty degeneration and interstitial fibrosis.Whereas electron microscope:nuclear glycogen granules;glycogen granules in cytoplasm increase;rough endoplasmic reticulum degranulation;smooth endoplasmic reticulum expansion;mitochondrial swelling, crista disorder or electron density increase;fatty degeneration;interstitial fibrosis.Conclusion:The most characteristic change of hepatic ultrastructure is nuclear glycogen granules in diabetes mellitus.

     

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  • []〔1〕沈稚舟 .肝脏疾病与糖代谢异常〔J〕 .国外医学·内科学分册 , 1994, 2 1 (6 ) ∶2 48.
    []〔2〕冼苏 , 王乃尊 , 韦敏怡 , 等 .糖尿病性肝肿大临床及病理研究〔J〕 .广西医科大学学报 , 1996 , 13 (3) ∶7.
    []〔3〕KumeE , OhmachiY , ItagakiS , etal.Hepaticchangesofmiceinthesub acutephaseofstreptozotopcin (SZ) induceddiabetes〔J〕 .ExpToxicolPathol.1994, 46 (4 5 ) ∶36 8.
    []〔4〕贾雪梅 , 齐易祥 , 王惠珠 , 等 .实验性糖尿病对小鼠肝脏酶组织化学和超微结构的影响〔J〕 .解剖学杂志 , 1995 , 18 (5 ) ∶45 1.
    []〔5〕Ferrannini, lanfranchiA , RohnerJeanrenaudF , etal.Influcenceoflong termdiabetesonliverglycogenmetabclismintherat〔J〕 .metabolism .1990 , 39 (10 ) ∶10 82 .
    []〔6〕武忠弼 , 主编 .超微病理学基础〔M〕 .北京 :人民卫生出版社 , 1990年 9月第一版 :2 0 .
    〔7〕ChatilaR , WestAB .Hepatomegalyandabnormallivertestsduetoglycogenosisinadultswithdiabetes〔J〕 .medicine Baltimore .1996 , 75 (6 ) ∶32 7.
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