肝病患者血清TGFα含量与肝功能的关系研究

To study the relationship between the change of transforming growth factor alpha (TGFα) level and liver function damage in different type of liver diseases By the method of RIA to detect the serum TGFα level, and auto biochemistry instrument to detect the serum liver function indexes∶ALT、AST、A/G、γ-GT、 AFP etc∶172 patients, serum TGFα level (x±s) had been detected, TGFα level of acute hepatitis was (14 19±7 30) pg/ml, chronic hepatitis (11 28±6 84) pg/ml, of compensation phase of liver cirrhosis (ccir) (8 14±5 55) pg/ml, of decompensation phase of liver cirrhosis (dcir) (16 02±9 18) pg/ml, and of hepatocellular carcinoma (19 89±9 09) pg/ml Except for ccir, each type of liver diseases was obviously higher than that of control group (6 86±0 89) pg/ml, (P<0 05) The TGFα of dcir was obviously higher than that of ccir (P<0 05) Serum TGFα was positively correlated with serum level of ALT, AST, γ GT and AFP (P<0 05) [WT5”BZ]Conclusion:[WT5”BZ]TGFα may associate with the chronic progress of liver diseases;the increaseing TGFα level may provide useful information for the diagnosis of hepatocellular carcinoma It is useful to detect TGFα level in helping the diagnosis and determining prognosis of liver diseases