CD15、CD44v6和CD54检测与肝癌复发转移的关系研究

To investigate the expressions of CD15, CD44v6 and CD54 in hepatocellular carcinoma (HCC) and their clinical significance, and to evaluate the relationship between their expressions and the invasion and metastasis of HCC, Surgi samples from 51 cases of HCC and their peritumorous tissues were detected by immunohistochemical technique In high potential of invasion and mestastasis group, the abnormal expressions of CD15?CD44v6 and CD54 were 40%, 45% and 55%, but, in low potential group, were 13%, 10% and 19%, respectively The expressions of CD15?CD44v6 and CD54 were significantly correlated with degree of differentiation of HCC The positive rates in Edmondson's HCC Ⅳ grade were higher than in Ⅱ grade The abnormal expressions of CD15?CD44v6 and CD54 were correlated with Edmondson's grade and the invasion and metastasis of HCC Detecting CD15?CD44v6 and CD54 may be a useful diagnostic parameter for the invasion and metastasis in HCC