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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2002
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血管紧张素Ⅱ1型受体mRNA在胆管阻塞性大鼠肝纤维化模型的表达及复方861的干预作用

  • Published Date: 2002-05-20
  • To study AT1 receptors mRNA expression in experimental liver fibrosis by bile duct occlusion in rats and the effect of compound (Cpd) 861. The bile ducts of forty five female Wistar rats were completely occluded by retrograde injection of Histoacryl and ligation. After operation, the rats were randomizedly divided into model group and 861 (9g/kg) treated group. In the latter daily gastric feeding of Cpd 861 started at the seventh day of operation and lasted for 49 days. Liver AT1 receptors mRNA expression was determined by semi-quantity RT-PCR. AT1 receptors mRNA levels of model group (1 038±0 064) was higher than that of control group (0 688±0 057 P <0 01) . Treated group was lower (0 705±0 142) than that of model group, P <0 01. AT1 receptors mRNA expression is remarkably up-regulated in rat liver fibrogenesis and AT1 receptors was possibly involved in the pathogenesis of liver fibrosis. AT1 receptors mRNA levels was down-regulated by Cpd 861.

     

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