To study the expression of TNF-α?TNFR and Bcl-2 family in patients with chronic hepatitis?liver cirrhosis and hepatocellular carcinoma. The apoptosis family in the liver tissue was studied by Nucleic acid molecular hybrodisation or immunohistochemistry. In 94 cases of TNFR in the liver cirrhosis group were significantly higher than that in chronic hepatitis and hepatocellular carcinoma group ( P <0 01) . The greater of expression level of TNF-α?TNFR and Fas in higher HAI. On the contrary, The lower of expression level of Bcl-2. It is suggested that TNF-α?TNFR and Bcl-2 famlily is involved in the regulation of apoptosis in the chronic liver diseases.
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