To research for lamivudine therapy causing severe hepatitis. 13 cases lamivudine therapy 3-23 months, Testing liver function, HBV message, HBV-YMDD gene. After lamivudine therapy, 13 cases bilirubin were above normal (P<0.01) , HBeAg, HBV-DNA levels were less than that before the lamivudine therapy (P<0.01) , 2 cases have HBV-YMDD mutants, 5 death cases, 4 recovery cases, 1 disconnecting case, 3 cases in hospital now. Long term lamivudine therapy may cause severe hepatitis. The clinical physician must pay more attention to use lamivudine.
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