螺旋藻阻断实验性大鼠肝纤维化机制的研究

To study the effects of spirulina in prevention of liver fibrosis in rats. Wistar rats were divided into three groups: control group (n=8) ;CCl 4 group (n=8) ; spirulina group (n=8) .CCl 4 group and spirulina group rats were induced by 40% CCl 4 olive oil solution into models of liver fibrosis, meanwhile spirulina group was given the feed with spirulina powder for 12w. Liver histological changes: hydroxyproline (HYP) content in liver tissues, serum LN, PC-Ⅲ, Ⅳ-C, HA, TNF-α and PDGF levels were observed. The pathological studies showed that the liver fibrosis degree of spirulina group was obviously lighter than that of CCl 4 group. Spirulina group had significantly lower levels of HYP, LN, Ⅳ-C (P<0.05) , PC-Ⅲ, HA, TNF-α and PDGF (P<0.01) than those of CCl 4 group. The experimental evidence suggests that spirulina can prevent the formation of liver fibrosis.