中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu
Issue 3
Mar.  2004
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Clinical Hepatology  > 2004  >  20(3): 161-162

拉米夫定耐药与HBV YMDD变异关系的研究

  • Published Date: 2004-03-20
    Abstract
  • To detect YMDD mutations of HBV by gene chips in patient with chronic hepatitis B treated with lamivudine and to evaluate its clinic importance. Sera of 102 patients with chronic hepatitis B treated with lamivudine 9-30 months were detected for ALT、HBV makers、YMDD mutation. In 102 patients, HBV DNA turned negative in 63 cases (61.8%) , 22 cases of YMDD mutations among 39 patients (56.4%) , its rate increasing with length of lamivudine treatment as rate was 51.7% between 9-17 months and rate 70% between 18-30 months. ALT level in patients with YMDD mutation was significant higher than the groups without YMDD mutation (59.94±8.60) U/L vs (50.60±6.12) U/L, P<0.05. Gene chips can be applied to identifying HBV YMDD mutant clinically; YMDD mutation is one of the reason that HBV resistant to lamivudine and may lead to elevation of ALT.

     

    • FullText(HTML)
    • References(4)
  • [1] YuenMF , SablonE , HuiCK , etal.FactorsassociatedwithhepatitisBvirusDNAbreakthroughinpatientsreceivingprolongedlamivudinethera py[J].Hepatology, 2001, 34 (4) ∶785-91.
    [2]李宜, 高人寿, 周陶友, 等.拉米夫定治疗慢性乙型肝炎的病原学研究[J].安徽医科大学学报, 2002, 37 (3) ∶206-208.
    [3]杨光, 王越建, 谭家驹.一种能够平行研究大量基因的新技术———基因芯片技术的原理和应用[J].胃肠病学和肝病学杂志, 2001, 10 (2) ∶176-181.
    [4] BozdayiAM , UzunalimogluO , TurkyilmazAR , etal.YSDD :anovelmutationinHBVDNApolymeraseconfersclinicalresistancetolamivu dine[J].JViralHepat, 2003, 10 (4) ∶256-265.
    • Relative Articles

  • Relative Articles

    [4]Li Jun, Chen XinYue, Zhao Hong, Yu YanYan, Si ChongWen, Han ZhongHou, Zhang WenJin, Chen YuPing, Chen Yong, Wang GuiQiang, Yu Min, Gong WeiBo, Xu JingHang, Wang Jun, Lin XiaoHong, Li XueYing. The relationship of hepatitis B virus genotypes and efficacy of lamivudine and interferon alpha 2b in the treatment of HBeAg-positive chronic hepatitis B[J]. Journal of Clinical Hepatology, 2008, 24(3): 169-171.
    [5]Su MingHua, Jiang JianNing, Zhou YuanPing, Chen MaoWei, Liu ZhiHong. Study of the relationship between BCP mutation in the hepatitis B virus gene and HBVDNA rebound after lamivudine therapy[J]. Journal of Clinical Hepatology, 2008, 24(3): 172-174.
    [10]Xu ZhengJu, Yang Hong, Zhang QiHua, Chen XianLi, Li ShuQing, Wang ChongGuo. Study on the relationship between hepatitis B virus genotypes and effect of lamivudine therapy.[J]. Journal of Clinical Hepatology, 2005, 21(3): 157-159.
    [12]Gu QiangYe, Chen HeMin. Therapeutic efficacy of combined application of Lamivudine and Ganluoxinpills in treating chronic hepatitis B and its in fluence on YMDD motif[J]. Journal of Clinical Hepatology, 2005, 21(2): 79-80.
    [16]Zhao Wei, Wan JianMin, Liu Wei, Liu QuanJun, Zhang Lin, Zhang HanRong, Liu XinYu, Zhou ZhenXian. Detection and identification of emergence of HBV YMDD motif mutation during lamivudine treatment by hybridization to an oligonucleotide array[J]. Journal of Clinical Hepatology, 2003, 19(3): 178-180.
    [19]Zhang HanRong, Liu XinYu, Zhong Bei, Fang ZhiXun. Clinical significance of mutation in the core promoter and the precore/core gene of hepatitis B virus in patients with chronic hepatitis B.[J]. Journal of Clinical Hepatology, 2002, 18(3): 177-179.
    [20]Xing LiHe, Shi Hong, Zhu ChuanLin, Li Li, Wang HuiFen. Relationship between the mutations in the core promotor and the response to interferon treatment in chronic hepatitis[J]. Journal of Clinical Hepatology, 2001, 17(3): 146-148.
    • Supplements(0)
    • Cited By
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-04010203040
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 6.0 %FULLTEXT: 6.0 %META: 92.6 %META: 92.6 %PDF: 1.4 %PDF: 1.4 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 1.8 %其他: 1.8 %其他: 0.2 %其他: 0.2 %China: 0.8 %China: 0.8 %Yongin-si: 0.2 %Yongin-si: 0.2 %上海: 2.8 %上海: 2.8 %中卫: 0.2 %中卫: 0.2 %丽水: 0.4 %丽水: 0.4 %佛山: 0.2 %佛山: 0.2 %北京: 6.0 %北京: 6.0 %十堰: 0.2 %十堰: 0.2 %南宁: 0.6 %南宁: 0.6 %南昌: 0.4 %南昌: 0.4 %台州: 2.4 %台州: 2.4 %吉林: 0.6 %吉林: 0.6 %哥伦布: 0.8 %哥伦布: 0.8 %天津: 0.2 %天津: 0.2 %孟买: 0.2 %孟买: 0.2 %宁波: 0.2 %宁波: 0.2 %广州: 0.2 %广州: 0.2 %张家口: 15.0 %张家口: 15.0 %德阳: 0.2 %德阳: 0.2 %成都: 0.6 %成都: 0.6 %昆明: 0.2 %昆明: 0.2 %杭州: 8.4 %杭州: 8.4 %武汉: 0.2 %武汉: 0.2 %淄博: 0.2 %淄博: 0.2 %淮安: 0.2 %淮安: 0.2 %深圳: 2.0 %深圳: 2.0 %温州: 0.6 %温州: 0.6 %湖州: 1.6 %湖州: 1.6 %石家庄: 0.4 %石家庄: 0.4 %芒廷维尤: 21.2 %芒廷维尤: 21.2 %苏州: 0.4 %苏州: 0.4 %莫斯科: 0.4 %莫斯科: 0.4 %葫芦岛: 0.2 %葫芦岛: 0.2 %衢州: 0.6 %衢州: 0.6 %西宁: 28.2 %西宁: 28.2 %郑州: 0.2 %郑州: 0.2 %金华: 0.4 %金华: 0.4 %长春: 0.2 %长春: 0.2 %长沙: 0.2 %长沙: 0.2 %其他其他ChinaYongin-si上海中卫丽水佛山北京十堰南宁南昌台州吉林哥伦布天津孟买宁波广州张家口德阳成都昆明杭州武汉淄博淮安深圳温州湖州石家庄芒廷维尤苏州莫斯科葫芦岛衢州西宁郑州金华长春长沙

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2415) PDF downloads(1180) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[2103]YesterdayPV[3576]TodayIP[81]TodayPV[106]Online[9]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return